Urinary tract infections in primary biliary cirrhosis and other chronic liver diseases

1997 ◽  
Vol 16 (10) ◽  
pp. 743-746 ◽  
Author(s):  
J. O'Donohue ◽  
M. R. Workman ◽  
N. Rolando ◽  
M. Yates ◽  
J. Philpott-Howard ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Primary Biliary Cirrhosis ◽  
Urinary Tract Infections ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Biliary Cirrhosis ◽  
Chronic Liver Diseases ◽  
Tract Infections

FLORID DUCT LESIONS AND EXTENSIVE BILE DUCT LOSS OF THE INTRAHEPATIC BILIARY TREE IN CHRONIC LIVER DISEASES OTHER THAN PRIMARY BILIARY CIRRHOSIS

1983 ◽  
Vol 33 (6) ◽  
pp. 1095-1104
Author(s):  
Yasuni Nakanuma ◽  
Goroku Ohta ◽  
Haruo Takeshita ◽  
Yoshikiyo Yamazaki ◽  
Kenji Doishita ◽  
...  
Keyword(s):  
Bile Duct ◽  
Primary Biliary Cirrhosis ◽  
Liver Diseases ◽  
Biliary Tree ◽  
Chronic Liver ◽  
Biliary Cirrhosis ◽  
Chronic Liver Diseases

scholarly journals Urisodeoxycholic Acid in Treatment of Liver Cirrhosis

2021 ◽  
Vol 9 (9) ◽  
pp. 1869-1873
Author(s):  
Sangale Mukta
Keyword(s):  
Liver Cirrhosis ◽  
Bile Acid ◽  
Primary Biliary Cirrhosis ◽  
Ursodeoxycholic Acid ◽  
Primary Sclerosing Cholangitis ◽  
Liver Diseases ◽  
Sclerosing Cholangitis ◽  
Chronic Liver ◽  
Biliary Cirrhosis ◽  
Chronic Liver Diseases

Abstract: Ursodeoxycholic acid is a dihy- droxy bile acid with a rapidly expanding spectrum of usage in acute and chronic liver diseases. The various mechanisms of action of this hydrophilic bile acid include direct cytoprotection, detergent action on dysfunctional microtubules, immunomodulation and induction of hypercholer- esis. Its efficacy in primary biliary cirrhosis and primary sclerosing cholangitis as an adjunct to medical therapy has been well established.Ursodeoxycholic acid prolongs survival in primary biliary cirrhosis and it improves biochemical parameters of cholestasis in various other cholestatic disorders including primary sclerosing cholangitis, intrahepatic cholestasis of pregnancy, cystic fibrosis and total parenteral nutritioninduced cholestasis. However, a positive effect on survival remains to be established in these diseases. Ursodeoxycholic acid is of unproven efficacy in non- cholestatic disorders such as acute rejection after liver transplantation, non-alcoholic steatohepatitis, alcoholic liver disease and chronic viral hepatitis. This review outlines the present knowledge of the Pharmacology of ursodeoxycholic acid, and presents data from clinical trials on its use in chronic liver diseases. Keywords: Liver cirrhosis, Urisodeoxycholic acid

scholarly journals Leukocyte migration inhibition in response to biliary antigens in primary biliary cirrhosis, sclerosing cholangitis, and other chronic liver diseases

1979 ◽  
Vol 76 (6) ◽  
pp. 1333-1340 ◽  
Author(s):  
Ian G. McFarlane ◽  
Barbara M. Wojcicka ◽  
Demetrios C. Tsantoulas ◽  
Bernard C. Portmann ◽  
Adrian L.W.F. Eddleston ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Liver Diseases ◽  
Sclerosing Cholangitis ◽  
Chronic Liver ◽  
Leukocyte Migration ◽  
Biliary Cirrhosis ◽  
Chronic Liver Diseases ◽  
Migration Inhibition ◽  
Leukocyte Migration Inhibition

Monomeric (7S) 1gM in primary biliary cirrhosis and other chronic liver diseases

1978 ◽  
Vol 75 (5) ◽  
pp. 963
Author(s):  
Y.M. Fakunle ◽  
H.C. Thomas ◽  
S. Sherlock
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Biliary Cirrhosis ◽  
Chronic Liver Diseases

scholarly journals Multi-Faceted Roles of Giloy: A Mini-Review

2021 ◽  
Vol 5 (1) ◽  
pp. 1-5
Author(s):  
Ghosh S
Keyword(s):  
Immune System ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Liver Diseases ◽  
The Body ◽  
Tinospora Cordifolia ◽  
Nutritional Content ◽  
Highly Effective ◽  
Tract Infections

In Ayurveda, Giloy is considered one of the best medicines to treat various fevers and other conditions. Giloy is one of the three Amrit plants. Amrit means the ‘root of immortality’. Hence, it is also called Amritavalli or Amrita in Sanskrit. Giloy is scientifically known as Tinospora cordifolia or Guduchi in Hindi. The stem of Giloy is considered highly effective because of its high nutritional content and the alkaloids found in it but the root and leaves also can be used. This herb activates the immune system of our body and increase vitality in a person. Inclusion of Giloy juice or kadha in diet twice a day can improve immunity. It is full of antioxidants and helps to release toxins from the body. Giloy juice also detoxifies skin and improves skin nourishment. Giloy is also used for liver diseases, urinary tract infections, and heart-related issues. Thus, Giloy can improve immunity and many other metabolisms in our body. However, more in depth researches are arrested to throw some light in immune enhancing activity of this herb.

scholarly journals Hyaluronic acid as a biomarker of fibrosis in chronic liver diseases of different etiologies

2016 ◽  
Vol 89 (1) ◽  
pp. 24-31 ◽  
Author(s):  
Olga Hilda Orasan ◽  
George Ciulei ◽  
Angela Cozma ◽  
Madalina Sava ◽  
Dan Lucian Dumitrascu
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Liver Diseases ◽  
Hereditary Hemochromatosis ◽  
Public Health Problem ◽  
Chronic Viral Hepatitis ◽  
Chronic Liver ◽  
Biliary Cirrhosis ◽  
Chronic Liver Diseases ◽  
Alcoholic Fatty Liver

Chronic liver diseases represent a significant public health problem worldwide. The degree of liver fibrosis secondary to these diseases is important, because it is the main predictor of their evolution and prognosis.Hyaluronic acid is studied as a non-invasive marker of liver fibrosis in chronic liver diseases, in an attempt to avoid the complications of liver puncture biopsy, considered the gold standard in the evaluation of fibrosis. We review the advantages and limitations of hyaluronc acid, a biomarker, used to manage patients with chronic viral hepatitis B or C infection, non-alcoholic fatty liver disease, HIV-HCV coinfection, alcoholic liver disease, primary biliary cirrhosis, biliary atresia, hereditary hemochromatosis and cystic fibrosis. 

scholarly journals Hepatic expression of sodium-dependent vitamin C transporters: ontogeny, subtissular distribution and effect of chronic liver diseases

2011 ◽  
Vol 106 (12) ◽  
pp. 1814-1825 ◽  
Author(s):  
Rocio I. R. Macias ◽  
Carlos Hierro ◽  
Susana Cuesta de Juan ◽  
Felipe Jimenez ◽  
Francisco Gonzalez-San Martin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Acid Uptake ◽  
Biliary Cirrhosis ◽  
Chronic Liver Diseases ◽  
Adult Rats ◽  
Hepatic Expression

Ascorbic acid uptake is a key step in determining the overall bioactivity of this vitamin. Expression of Na-dependent vitamin C transporters (SVCT; SLC23A1 and SLC23A2) during long-term oxidative stress occurring in several chronic liver diseases may determine the antioxidant defence in this organ. In patients with hepatocellular cholestasis, primary biliary cirrhosis, haemochromatosis and non-alcoholic steatohepatitis, using real-time RT-PCR, an enhanced hepatic expression of both SLC23A1 and SLC23A2, but not other organic anions transporters, such as OATP1A2, OATP1B1 and OATP1B3, was found. To further investigate these findings, we used secondary biliary cirrhosis induced in rats by long-term biliary obstruction as a model of chronic liver disease accompanied by oxidative stress because of bile acid accumulation. In control rat liver, expression of Slc23a1 was low at birth, increased progressively up to adulthood and decreased in senescence, whereas expression of Slc23a2 did not change significantly after birth. In 8-week-old rats, immunohistochemistry and confocal microscopy studies revealed the expression in hepatocytes and bile duct cells of mainly Slc23a1, whereas both Slc23a1 and Slc23a2 were expressed in endothelial, stellate and Kupffer cells. In adult rats, when obstructive cholestasis was maintained for 8 weeks, a significant up-regulation of Slc23a2 accompanied by a down-regulation of Slc23a1 was found. In sum, there is a selective cell-type distribution of SVCT in the liver tissue, which, in addition to differential control in the expression of both isoforms, may play a role in the ability of different liver cell types to take up vitamin C under physiological and pathological conditions.

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