Risk factors for histologically confirmed benign breast tumors

1994 ◽  
Vol 10 (3) ◽  
pp. 259-265 ◽  
Author(s):  
Matti Rautalahti ◽  
Demetrius Albanes ◽  
Jari Haukka ◽  
Jarmo Virtamo
Keyword(s):  
Risk Factors ◽  
Breast Tumors ◽  
Benign Breast Tumors

Benign Breast Tumors

2019 ◽  
pp. 17-38
Author(s):  
Emilia Josefa Borromeo Diego
Keyword(s):  
Breast Tumors ◽  
Benign Breast Tumors

scholarly journals Characterization of N-ethyl-N-nitrosourea-induced malignant and benign breast tumors in rats by using three MR contrast agents

1999 ◽  
Vol 9 (2) ◽  
pp. 177-186 ◽  
Author(s):  
Min-Ying Su ◽  
Zhiheng Wang ◽  
Philip M. Carpenter ◽  
Xiaoyan Lao ◽  
Andreas M�hler ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Breast Tumors ◽  
Mr Contrast Agents ◽  
Benign Breast Tumors

Experience in performing organ-preserving and reconstructive plastic surgeries for malignant breast tumors at the Regional Clinical Center of Oncology in Khabarovsk

2021 ◽  
Vol 87 (1) ◽  
pp. 32-36
Author(s):  
A.A. Chernyayeva ◽  
◽  
A.S. Zenyukov ◽  
S.M. Korneyev ◽  
Ye.G. Lokalov ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Local Recurrence ◽  
Clinical Oncology ◽  
Breast Tumors ◽  
Clinical Center ◽  
Malignant Breast ◽  
Oncology Center ◽  
Reconstructive Plastic

The article presents the experience of the Oncology department No. 1 of the Regional Clinical Oncology Center in Khabarovsk in performing organ-preserving and reconstructive plastic surgeries for breast cancer in the period 2014–2019. An assessment was made of the incidence of local recurrence or distant progression of the disease, as well as risk factors for their occurrence

scholarly journals Oncoplastic Approach to Giant Benign Breast Tumors Presenting as Unilateral Macromastia

2020 ◽  
Vol 53 (03) ◽  
pp. 439-441
Author(s):  
Lekshmi Malathi
Keyword(s):  
Reduction Mammaplasty ◽  
Breast Tumors ◽  
Oncoplastic Surgery ◽  
Breast Symmetry ◽  
Large Size ◽  
Skin Envelope ◽  
Giant Lipoma ◽  
Giant Fibroadenoma ◽  
Skin Retraction ◽  
Benign Breast Tumors

AbstractBenign breast tumors attaining large size constitute an important cause of unilateral macromastia. Their usual treatment involves enucleation or excision with a margin based on pathology and waiting for spontaneous retraction of skin envelope. In very large tumors, this will leave the residual breast deflated and unaesthetic, with spontaneous skin retraction giving unpredictable results. Application of the principles of oncoplastic surgery are helpful in this situation. Here, we present two cases of benign giant tumors—a giant fibroadenoma and a giant lipoma—managed by reduction mammaplasty approach to restore the breast symmetry and aesthetics.

scholarly journals Clinicopathological Significances of Cancer Stem Cell-Associated HHEX Expression in Breast Cancer

2020 ◽  
Vol 8 ◽  
Author(s):  
Kexin Zhang ◽  
Qi Zhao ◽  
Zugui Li ◽  
Fangmei Fu ◽  
Hao Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
Precancerous Lesions ◽  
Breast Tumors ◽  
Clinicopathological Parameters ◽  
Migration And Invasion ◽  
Gene Marker ◽  
Aberrant Expression ◽  
Benign Breast Tumors

Aberrant expression of the transcription factor hematopoietic ally expressed homeobox/proline-rich homeodomain (HHEX/PRH) is implicated in numerous cancers. However, the association of HHEX with breast cancer (BC) remains unclear. In this study, HHEX mRNA and protein expression were analyzed using the Oncomine, UALCAN, GEPIA, TCGAportal, and HPA databases. We evaluated the effect of HHEX on clinicopathological parameters using Kaplan–Meier plotter, OncoLnc, TCGAportal, PROGgeneV2, and BC-GenExMiner. Western blotting was performed to compare the level of HHEX in breast samples of Tientsin Albino 2 mice, human breast precancerous lesions, benign breast tumors, and BC. The correlation between HHEX and cancer stem cells was investigated using the GEO (GSE52327 and GSE94865) and GEPIA datasets. Networks between HHEX and survival-related gene marker sets and microRNAs were analyzed using GEPIA, StarBase, and Cytoscape. Results of this study showed that HHEX expression in BC was significantly lower than those in breast precancerous lesions and benign breast tumors at both mRNA and protein levels. BC patients with lower HHEX expression had significantly worse overall survival and disease-free survival. Moreover, HHEX significantly affected the clinicopathology of BC. Specifically, low HHEX expression was correlated with the following groups of patients: age ≤51 years, ER-negative or PR-negative patients, HER-2 positive, triple-negative breast cancer, and basal-like BC. Immunohistochemical analysis of the breast samples showed significant differences of HHEX staining index (P < 0.001) among the three groups. To further investigate the mechanism, we determined the intersection of differentially expressed genes related to BC stem cells and those genes after HHEX expression was altered. This led to the identification of four potentially regulated genes-CXL12, BLNK, PAG1, and LPXN. Using StarBase and km-plotter, the negative regulation of HHEX expression and survival trends, including miR-130b, miR-30e, and miR-301b were joined into miRNA-HHEX-mRNA potential regulatory network. The abilities of proliferation, migration and invasion increased in MDA-MB-231 and BT-549 breast cancer cell lines after HHEX down expression and decreased after HHEX overexpression compared them in the control cells. In conclusion, these data suggest that HHEX expression is downregulated in BC and HHEX may regulate the development of BC through the stem cell-related genes.

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