Metallothionein induction in cultured rat hepatocytes by arthritic rat serum, activated macrophages, interleukin-6, interleukin-11 and leukaemia inhibitory factor

1995 ◽  
Vol 44 (11) ◽  
pp. 475-481 ◽  
Author(s):  
P. Coyle ◽  
J. C. Philcox ◽  
A. M. Rofe
1997 ◽  
Vol 40 (6) ◽  
pp. 1096-1105 ◽  
Author(s):  
Hideyuki Okamoto ◽  
Masahiro Yamamura ◽  
Yoshitaka Morita ◽  
Seishi Harada ◽  
Hirofumi Makino ◽  
...  

1999 ◽  
Vol 14 (Suppl_3) ◽  
pp. 368-368
Author(s):  
T. Strowitzki ◽  
M. von Wolff ◽  
C.J. Thaler ◽  
S. Stieger ◽  
C. Zepf ◽  
...  

1998 ◽  
Vol 329 (2) ◽  
pp. 335-339 ◽  
Author(s):  
Joanna CICHY ◽  
Stefan ROSE-JOHN ◽  
James TRAVIS

Interleukin 6 (IL-6), oncostatin M (OSM) and leukaemia-inhibitory factor (LIF) share a common signal-transducing subunit in each of their receptors and thus mediate an overlapping spectrum of biological activities. Although all of these cytokines stimulate the production of α1-proteinase inhibitor (α1-PI) in hepatocyte-derived cells, only OSM is able to up-regulate levels of this inhibitor in epithelial cells originating from the lung. In this study we characterized human lung-derived epithelial-like HTB58 cells for their ability to synthesize α1-PI after treatment with IL-6, OSM and LIF. The results demonstrate that the resistance of HTB58 cells to the effects of IL-6 and LIF was not because of a lack of their individual functional receptors and suggest that OSM utilizes two different receptors, gp130/LIF receptor and gp130/OSM receptor, in lung-derived epithelial cells.


1991 ◽  
Vol 178 (3) ◽  
pp. 1049-1055 ◽  
Author(s):  
Joseph F. Williams ◽  
William J. Bement ◽  
Jacqueline F. Sinclair ◽  
Peter R. Sinclair

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