Haemopoietic stem cells in mice chronically exposed to styrene vapour

1990 ◽  
Vol 64 (6) ◽  
pp. 466-469 ◽  
Author(s):  
Hans Joachim Seidel ◽  
Jochen Herkommer ◽  
Dietmar Seitz ◽  
Lothar Weber ◽  
Edda Barthel
Keyword(s):  
Stem Cells ◽  
Haemopoietic Stem Cells

On the origin of haemopoietic stem cells in the avian embryo: an experimental approach

Development ◽  
1975 ◽  
Vol 33 (3) ◽  
pp. 607-619
Author(s):  
par Françoise Dieterlen-Lievre
Keyword(s):  
Stem Cells ◽  
Blood Cell ◽  
Experimental Approach ◽  
Developmental Stages ◽  
Yolk Sac ◽  
Avian Embryo ◽  
Cell Nuclei ◽  
Haemopoietic Stem Cells ◽  
Cell Series ◽  
Haemopoietic Cells

It is currently accepted that stem cells of the definitive blood cell lines originate from the yolk-sac blood islands. Experiments were devised to examine the validity of this theory in the avian embryo. These involved grafting two-day-old quail embryos on to chick yolk-sacs of comparable developmental stages, i.e. before or shortly after the establishment of vascularization.The conclusions of the experiments are based on the possibility of distinguishing chick cell nuclei from those of the quail. In the developing haemopoietic organs (spleen and thymus) of quail embryos grafted on to the chick and subsequently incubated for 6–11 days, all cells, whether belonging to the granulopoietic, erythropoietic or lymphopoietic series, are of quail type. Thus these organs have not been colonized by chick stem cells. On the other hand, coelomic graft experiments show that the development of these organs is indeed dependent on an extrinsic colonization by haemopoietic cells; quail spleen or thymus rudiment, developing in the coelom of a chick, is populated by chick cells. Thus no incompatibility which would prevent heterospecific colonization exists in this system. It is concluded that haemopoietic stem cells of the definitive blood cell series originate from some source other than the yolk-sac, and that this source must be intra-embryonic.

scholarly journals Regulation of Cell Growth

1987 ◽  
Vol 80 (9) ◽  
pp. 591-593
Author(s):  
A J Barrett
Keyword(s):  
Stem Cells ◽  
Growth Factors ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cell Growth ◽  
Cell Lines ◽  
Growth Regulation ◽  
Platelet Derived Growth Factor ◽  
Haemopoietic Stem Cells

At this meeting of the RSM's Section of Pathology, the regulation of haemopoietic stem cells and growth factors regulating various cell lines were described, and the role of oncogenes, platelet-derived growth factor and nerve growth factor in growth regulation was discussed.

scholarly journals Recovery of haemopoietic stem cells of W/Wv mice after irradiation: In vivo and in vitro studies.

1981 ◽  
Vol 22 (4) ◽  
pp. 405-414 ◽  
Author(s):  
K. J. MORI ◽  
Y. KITAMURA ◽  
T. MIYANOMAE ◽  
K. KUMAGAI ◽  
A. SETO
Keyword(s):  
Stem Cells ◽  
In Vitro Studies ◽  
Haemopoietic Stem Cells

Failure to detect the presence of pluripotential haemopoietic stem cells in the mouse brain

1988 ◽  
Vol 18 (3) ◽  
pp. 217-222 ◽  
Author(s):  
J. Štědra ◽  
Z. Lodin ◽  
P. Rossmann ◽  
J. Hartman ◽  
J. Šterzl
Keyword(s):  
Stem Cells ◽  
Mouse Brain ◽  
Haemopoietic Stem Cells

HAEMOPOIETIC STEM CELLS

1975 ◽  
Vol 29 (4) ◽  
pp. 529-535 ◽  
Author(s):  
L. G. Lajtha
Keyword(s):  
Stem Cells ◽  
Haemopoietic Stem Cells

Apoptosis in the haemopoietic system

1994 ◽  
Vol 345 (1313) ◽  
pp. 257-263 ◽  
Keyword(s):  
Stem Cells ◽  
Growth Factors ◽  
Growth Factor ◽  
Cell Survival ◽  
Lineage Differentiation ◽  
Haemopoietic Stem Cells ◽  
Underlying Causes ◽  
Membrane Bound ◽  
Survival Signals

Our previous studies have shown that haemopoietic stem cells undergo apoptotic death as a consequence of growth factor withdrawal. In this paper we review the new data that has accumulated since this observation and compare it with older data from the ‘pre-apoptotic’ age. Models of erythropoiesis and granulopoiesis that incorporate apoptosis as a normal physiological process controlling homeostasis are examined. The converse to cell death is cell survival, and we describe experiments which suggest that haemopoietic growth factors can not only act as mitogenic or differentiation stimuli but also act as survival signals. We, and others, have proposed that these growth factor-induced survival signals act through the membrane bound polypeptide receptors and share common features of signal transduction with proliferative responses. Enforced expression of bcl-2 in haemopoietic stem cells is able to overcome apoptosis following the withdrawal of growth factor, and the cells commit into different lineage differentiation programmes. Such cells spontaneously differentiate without cell division, suggesting a stochastic model of haemopoiesis in which the major role of haemopoietic growth factors is to suppress apoptosis and act as mitogens. We review the evidence that the underlying causes of some haematological diseases may be associated with change in the balance between cell survival and death.

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