Serum and secretory IgA immune response to Klebsiella pneumoniae in ankylosing spondylitis

1983 ◽  
Vol 2 (4) ◽  
pp. 331-337 ◽  
Author(s):  
A. K. Trull ◽  
G. S. Panayi
Keyword(s):  
Immune Response ◽  
Ankylosing Spondylitis ◽  
Klebsiella Pneumoniae ◽  
Secretory Iga

Development of immune response in pneumonia caused by Klebsiella pneumoniae (part 3)

2017 ◽  
pp. 53-63
Author(s):  
O.E. Abaturov ◽  
◽  
A.O. Nikulina ◽  
Keyword(s):  
Immune Response ◽  
Klebsiella Pneumoniae

Development of the immune response in pneumonia caused Klebsiella pneumoniae. Part 2

2017 ◽  
pp. 68-79
Author(s):  
O.E. Abaturov ◽  
◽  
A.O. Nikulina ◽  
Keyword(s):  
Immune Response ◽  
Klebsiella Pneumoniae

scholarly journals Klebsiella pneumoniae and acute anterior uveitis in ankylosing spondylitis.

BMJ ◽  
1979 ◽  
Vol 1 (6160) ◽  
pp. 383-383 ◽  
Author(s):  
R Ebringer ◽  
D Cawdell ◽  
A Ebringer
Keyword(s):  
Ankylosing Spondylitis ◽  
Klebsiella Pneumoniae ◽  
Anterior Uveitis ◽  
Acute Anterior Uveitis

Enteric Microorganisms in Rheumatoid Diseases: Causative Agents and Possible Mechanisms

1985 ◽  
Vol 48 (6) ◽  
pp. 538-545 ◽  
Author(s):  
DOUGLAS L. ARCHER
Keyword(s):  
Immune Response ◽  
Ankylosing Spondylitis ◽  
Molecular Mechanisms ◽  
Enteric Pathogens ◽  
Gastrointestinal Illness ◽  
Hla B27 ◽  
Causative Agents ◽  
Related Individuals ◽  
Rheumatoid Diseases

The role of foodborne enteric pathogens in the development of three seronegative spondarthropathies (ankylosing spondylitis, Reiter's disease and reactive arthritis) is discussed. Although the prevalence of the HLA-B27 antigen in blood-related individuals suggests a genetic predisposition to these diseases, exogenous environmental factors are also indicated. A clinical profile is given to clarify certain relationships of the seronegative arthropathies. Evidence of the involvement of enteric pathogens in the onset of these conditions following gastrointestinal illness is considered along with the interactions of general and molecular mechanisms of the disease processes and the immune response.

scholarly journals Genetic Polymorphisms of Toll-like receptors 2 and 9 as Susceptibility Factors for the Development of Ankylosing Spondylitis and Psoriatic Arthritis

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Camila F. Oliveira-Toré ◽  
Amarilis G. Moraes ◽  
Gabriela F. Martinez ◽  
Janisleya S. F. Neves ◽  
Luciana C. Macedo ◽  
...  
Keyword(s):  
Immune Response ◽  
Psoriatic Arthritis ◽  
Ankylosing Spondylitis ◽  
Genetic Polymorphisms ◽  
Inflammatory Responses ◽  
Strong Association ◽  
Adaptive Immune Response ◽  
Inflammatory Rheumatic Diseases ◽  
Toll Like Receptors ◽  
Immunological Mechanisms

Introduction. Ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are classified as spondyloarthritis (SpA), a group of inflammatory rheumatic diseases with complex genetic etiology. Toll-like receptors (TLRs) have an important role in the mechanism of innate immunity and may influence inflammatory responses. Polymorphisms in TLR genes that lead to changes in these receptors or that interfere with the transcription rates of mRNA TLR may be involved in the chronic inflammatory immune response observed in SpA. Currently, there is a lack of studies associating genetic polymorphisms in TLRs and SpA. Objective. Therefore, this case-control study is aimed at analyzing the influence of the respective SNPs on TLR2 rs5743708, TLR6 rs5743810, and TLR9 rs5743836 and rs187084 in the immunopathogenesis of SpA. Methods. The polymorphisms genotyped by PCR-RFLP were TLR2 rs5743708, TLR6 rs5743810, and TLR9 rs5743836 and rs187084. The HLA-B∗27 was performed by PCR-SSP. Results. Logistic regression analysis showed a strong association between SNPs in TLR2 and TLR9 and susceptibility to SpA (OR=12.56; CI=6.5-25.9 and OR=1.62; CI=1.20-2.21, respectively). No association was observed among HLA-B∗27 and TLR polymorphisms (p=0.72), nor among BASDAI and TLR polymorphisms (p=0.85). Discussion. Our findings suggest that polymorphisms in TLR2 and TLR9 genes may contribute to the immunopathogenesis of the SpA. The rs187084, rs5743836, and rs5743708 polymorphisms were associated with the risk of SpA development, in this study, and lead to significant changes in the innate and adaptive immune response profile, as well as the maintenance of the regulation of immunological mechanisms. Conclusion. The polymorphism rs5743708 for the TLR2 and the rs187084_rs5743836 TLR9 haplotypes appear to be involved in the development of clinical forms of SpA and can be a possible therapeutic target for the spondyloarthritis.

Inhibition of Klebsiella pneumoniae growth by selected Australian plants: natural approaches for the prevention and management of ankylosing spondylitis

2017 ◽  
Vol 25 (2) ◽  
pp. 223-235 ◽  
Author(s):  
V. Winnett ◽  
J. Sirdaarta ◽  
A. White ◽  
F. M. Clarke ◽  
I. E. Cock
Keyword(s):  
Ankylosing Spondylitis ◽  
Klebsiella Pneumoniae

scholarly journals Effect of Dietary Supplementation of Spirulina (Arthrospira Platensis) and Thyme (Thymus Vulgaris) on Serum Biochemistry, Immune Response and Antioxidant Status of Rabbits

2016 ◽  
Vol 16 (1) ◽  
pp. 181-195 ◽  
Author(s):  
Melinda Kovács ◽  
Tamás Tuboly ◽  
Miklós Mézes ◽  
Krisztián Balogh ◽  
Zsolt Gerencsér ◽  
...  
Keyword(s):  
Immune Response ◽  
Antioxidant Status ◽  
Experimental Period ◽  
Serum Biochemistry ◽  
Arthrospira Platensis ◽  
Secretory Iga ◽  
Thymus Vulgaris ◽  
Creatinine Concentration ◽  
Antioxidant Parameters ◽  
Group 3

Abstract Growing rabbits’ (42 rabbits/group, 3 rabbits/cage, 14 cages/treatment) diet was supplemented with 5% Spirulina (Arthrospira platensis) and 3% thyme (Thymus vulgaris L.) powder single (S or T) and in combination (ST) between 35 and 77 days of age. On day 0 (weaning at 35 days of age) 14 rabbits were vaccinated with 100 μg/animal ovalbumin to provoke immune response. Blood samples were taken on days 0, 14, 28 and 42 of the experimental period. Sampling dates significantly influenced total protein, albumin, glucose, cholesterol, urea, creatinine concentration and enzyme (AST, ALT, GGT) activities, with a significant age × diet interaction in the case of TP and CREA. There was a significant increase in ALT (+45 and 74%) and GGT (+87 and 102%) activity after immunisation. While Spirulina and thyme significantly ameliorated the rise in AST activity, their effect was inefficient in the case of GGT. Spirulina, both single and in combination showed a tendency in higher IgG level as compared to control (P<0.05). No significant effect of sampling date or treatment on phagocytic activity or secretory IgA was demonstrable (P>0.05). Higher MDA concentration was measured in the red blood cells of S, T and ST animals, while no other significant diet effect on the antioxidant parameters was detected, however, significant sampling date × diet interaction was found in the case of GPx activity. Plasma GGT (increase by 19-66%) was inversely associated with GSH (decrease by 66-113%) between days 0 to 42 of the experimental period (r=-0.57, P<0.05). It can be concluded that Spirulina supplementation alone resulted in higher IgG production, but none of the phytobiotics, at the dose used, affected significantly the antioxidant status of blood.

scholarly journals The Link between Ankylosing Spondylitis, Crohn’s Disease,Klebsiella, and Starch Consumption

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Taha Rashid ◽  
Clyde Wilson ◽  
Alan Ebringer
Keyword(s):  
Crohn’S Disease ◽  
Ankylosing Spondylitis ◽  
Crohn's Disease ◽  
Klebsiella Pneumoniae ◽  
Dietary Intake ◽  
Therapeutic Effect ◽  
Hla B27 ◽  
Daily Dietary Intake ◽  
Pathological Lesions ◽  
Triggering Factor

Both ankylosing spondylitis (AS) and Crohn’s disease (CD) are chronic and potentially disabling interrelated conditions, which have been included under the group of spondyloarthropathies. The results of a large number of studies support the idea that an enteropathic pathogen,Klebsiella pneumoniae, is the most likely triggering factor involved in the initiation and development of these diseases. Increased starch consumptions by genetically susceptible individuals such as those possessing HLA-B27 allelotypes could trigger the disease in both AS and CD by enhancing the growth and perpetuation of theKlebsiellamicrobes in the bowel. Exposure to increased levels of these microbes will lead to the production of elevated levels of anti-Klebsiellaantibodies as well as autoantibodies against cross-reactive self-antigens with resultant pathological lesions in the bowel and joints. Hence, a decrease of starch-containing products in the daily dietary intake could have a beneficial therapeutic effect on the disease especially when used in conjunction with the currently available medical therapies in the treatment of patients with AS and CD.

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