Testosterone and progesterone metabolism in the central nervous system: Cellular localization and mechanism of control of the enzymes involved

1996 ◽  
Vol 16 (3) ◽  
pp. 271-282 ◽  
Author(s):  
L. Martini ◽  
F. Celotti ◽  
R. C. Melcangi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cellular Localization ◽  
Progesterone Metabolism ◽  
The Central Nervous System

scholarly journals Dynamic Role of Phospholipases A2 in Health and Diseases in the Central Nervous System

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2963
Author(s):  
Grace Y. Sun ◽  
Xue Geng ◽  
Tao Teng ◽  
Bo Yang ◽  
Michael K. Appenteng ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cellular Localization ◽  
Cell Types ◽  
Molecular Structures ◽  
Specific Cell ◽  
Phospholipases A2 ◽  
Cell Functions ◽  
The Central Nervous System

Phospholipids are major components in the lipid bilayer of cell membranes. These molecules are comprised of two acyl or alkyl groups and different phospho-base groups linked to the glycerol backbone. Over the years, substantial interest has focused on metabolism of phospholipids by phospholipases and the role of their metabolic products in mediating cell functions. The high levels of polyunsaturated fatty acids (PUFA) in the central nervous system (CNS) have led to studies centered on phospholipases A2 (PLA2s), enzymes responsible for cleaving the acyl groups at the sn-2 position of the phospholipids and resulting in production of PUFA and lysophospholipids. Among the many subtypes of PLA2s, studies have centered on three major types of PLA2s, namely, the calcium-dependent cytosolic cPLA2, the calcium-independent iPLA2 and the secretory sPLA2. These PLA2s are different in their molecular structures, cellular localization and, thus, production of lipid mediators with diverse functions. In the past, studies on specific role of PLA2 on cells in the CNS are limited, partly because of the complex cellular make-up of the nervous tissue. However, understanding of the molecular actions of these PLA2s have improved with recent advances in techniques for separation and isolation of specific cell types in the brain tissue as well as development of sensitive molecular tools for analyses of proteins and lipids. A major goal here is to summarize recent studies on the characteristics and dynamic roles of the three major types of PLA2s and their oxidative products towards brain health and neurological disorders.

scholarly journals CELLULAR LOCALIZATION OF INSULIN-LIKE IMMUNOREACTIVITY IN THE CENTRAL NERVOUS SYSTEM OF SPINY MICE, C57B16J AND C57B1KSJ MICE

1980 ◽  
Vol 13 (6) ◽  
pp. 623-626 ◽  
Author(s):  
HANS-GERT BERNSTEIN ◽  
ALFRED DORN ◽  
HANS-JURGEN HAHN ◽  
GERDA KOSTMANN ◽  
MANFRED ZIEGLER
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cellular Localization ◽  
Spiny Mice ◽  
The Central Nervous System

Cellular localization of lipocalin-type prostaglandin D synthase (?-trace) in the central nervous system of the adult rat

2000 ◽  
Vol 428 (1) ◽  
pp. 62-78 ◽  
Author(s):  
Carsten T. Beuckmann ◽  
Michael Lazarus ◽  
Dmitry Gerashchenko ◽  
Akira Mizoguchi ◽  
Sakashi Nomura ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cellular Localization ◽  
Adult Rat ◽  
Prostaglandin D Synthase ◽  
The Central Nervous System

Cellular localization of monoamine oxidase A and B in human tissues outside of the central nervous system

2001 ◽  
Vol 304 (2) ◽  
pp. 215-220 ◽  
Author(s):  
Manuel J. Rodríguez ◽  
Josep Saura ◽  
Ellen E. Billett ◽  
Cheryl C. Finch ◽  
Nicole Mahy
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Monoamine Oxidase ◽  
Cellular Localization ◽  
Monoamine Oxidase A ◽  
Human Tissues ◽  
The Central Nervous System
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