Cellular localization of monoamine oxidase A and B in human tissues outside of the central nervous system

2001 ◽  
Vol 304 (2) ◽  
pp. 215-220 ◽  
Author(s):  
Manuel J. Rodríguez ◽  
Josep Saura ◽  
Ellen E. Billett ◽  
Cheryl C. Finch ◽  
Nicole Mahy
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Monoamine Oxidase ◽  
Cellular Localization ◽  
Monoamine Oxidase A ◽  
Human Tissues ◽  
The Central Nervous System

scholarly journals Expression of c-kit and kit ligand proteins in normal human tissues.

1994 ◽  
Vol 42 (11) ◽  
pp. 1417-1425 ◽  
Author(s):  
A Lammie ◽  
M Drobnjak ◽  
W Gerald ◽  
A Saad ◽  
R Cote ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Critical Role ◽  
Regional Distribution ◽  
Cervix Uterus ◽  
Sweat Glands ◽  
Human Tissues ◽  
Mouse Development ◽  
Normal Tissues ◽  
The Central Nervous System

The c-kit receptor and its cognate ligand, KL, play a critical role in melanogenesis, gametogenesis, and hematopoiesis. Studies on the expression of c-kit and KL have been primarily focused on mouse development. We undertook the present study to characterize the pattern of expression of these molecules in normal adult human tissues. Using immunohistochemistry and consecutive tissue sections from the same block, we evaluated a variety of well-preserved normal tissues for c-kit and KL microanatomic distribution. c-kit protein was identified in tissue mast cells, melanocytes, glandular epithelial cells of breast, parotid, dermal sweat, and esophageal glands. Scattered c-kit immunoreactivity was also observed for testicular and ovarian interstitial cells. A striking regional distribution of c-kit was detected in the central nervous system, particularly in the cerebellum, hippocampus, and dorsal horn of the spinal cord. KL protein was identified in cells complementary to staining for the receptor, such as glandular myoepithelium of breast and sweat glands. Intense KL immunoreactivity was observed in smooth muscle cells of the bladder, cervix, uterus, and gastrointestinal tract, as well as in striated and cardiac muscle. Strong KL staining was also detected in prostate fibromuscular stroma cells. In the central nervous system, KL expression was confined to Golgi and Purkinje cells in the cerebellum. These results suggest a role for this receptor and its ligand in the maintenance of a variety of fully differentiated tissues.

scholarly journals Roles of Hostility and Depression in the Association between the MAOA Gene Polymorphism and Internet Gaming Disorder

2021 ◽  
Vol 18 (13) ◽  
pp. 6910
Author(s):  
Ju-Yu Yen ◽  
Wei-Po Chou ◽  
Huang-Chi Lin ◽  
Hung-Chi Wu ◽  
Wen-Xiang Tsai ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Odds Ratio ◽  
Internet Gaming Disorder ◽  
Monoamine Oxidase A ◽  
Gaming Disorder ◽  
Maoa Gene ◽  
Internet Gaming ◽  
The Central Nervous System ◽  
Behavior And Cognition

The metabolism of bioamine in the central nervous system contributes to the development of addiction. We examined the roles of hostility and depression in the association between internet gaming disorder (IGD) and monoamine oxidase-A (MAOA) EcoRV polymorphism (rs1137070). A total of 69 adults with IGD and 138 without IGD were recruited through diagnostic interviewing. We evaluated participants for rs1137070, depression, and hostility. The participants with the TT genotype of rs1137070 had a higher odds ratio of 2.52 (1.37–4.64) for IGD compared with the C carriers. Expressive hostility behavior and hostility cognition mediated the association between rs1137070 and IGD. Indicating lower MAOA activity, the TT genotype predicted IGD and higher expressive hostility behavior and hostility cognition. Expressive hostility behavior and hostility cognition may underline the association between rs1137070 and IGD. Assessment of and intervention for hostility behavior and cognition should be provided to attenuate the risk of IGD, particularly in those with the TT genotype. Further brain imaging or neurobiological studies are required to elucidate the possible mechanism underlying the association between MAOA activity and IGD.

scholarly journals Dynamic Role of Phospholipases A2 in Health and Diseases in the Central Nervous System

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2963
Author(s):  
Grace Y. Sun ◽  
Xue Geng ◽  
Tao Teng ◽  
Bo Yang ◽  
Michael K. Appenteng ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cellular Localization ◽  
Cell Types ◽  
Molecular Structures ◽  
Specific Cell ◽  
Phospholipases A2 ◽  
Cell Functions ◽  
The Central Nervous System

Phospholipids are major components in the lipid bilayer of cell membranes. These molecules are comprised of two acyl or alkyl groups and different phospho-base groups linked to the glycerol backbone. Over the years, substantial interest has focused on metabolism of phospholipids by phospholipases and the role of their metabolic products in mediating cell functions. The high levels of polyunsaturated fatty acids (PUFA) in the central nervous system (CNS) have led to studies centered on phospholipases A2 (PLA2s), enzymes responsible for cleaving the acyl groups at the sn-2 position of the phospholipids and resulting in production of PUFA and lysophospholipids. Among the many subtypes of PLA2s, studies have centered on three major types of PLA2s, namely, the calcium-dependent cytosolic cPLA2, the calcium-independent iPLA2 and the secretory sPLA2. These PLA2s are different in their molecular structures, cellular localization and, thus, production of lipid mediators with diverse functions. In the past, studies on specific role of PLA2 on cells in the CNS are limited, partly because of the complex cellular make-up of the nervous tissue. However, understanding of the molecular actions of these PLA2s have improved with recent advances in techniques for separation and isolation of specific cell types in the brain tissue as well as development of sensitive molecular tools for analyses of proteins and lipids. A major goal here is to summarize recent studies on the characteristics and dynamic roles of the three major types of PLA2s and their oxidative products towards brain health and neurological disorders.

scholarly journals CELLULAR LOCALIZATION OF INSULIN-LIKE IMMUNOREACTIVITY IN THE CENTRAL NERVOUS SYSTEM OF SPINY MICE, C57B16J AND C57B1KSJ MICE

1980 ◽  
Vol 13 (6) ◽  
pp. 623-626 ◽  
Author(s):  
HANS-GERT BERNSTEIN ◽  
ALFRED DORN ◽  
HANS-JURGEN HAHN ◽  
GERDA KOSTMANN ◽  
MANFRED ZIEGLER
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cellular Localization ◽  
Spiny Mice ◽  
The Central Nervous System
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