Contact transmission of experimental contagious caprine pleuropneumonia (CCPP)

1977 ◽  
Vol 9 (4) ◽  
pp. 185-188 ◽  
Author(s):  
K. J. MacOwan ◽  
Jean E. Minette
Keyword(s):  
Contagious Caprine Pleuropneumonia ◽  
Contact Transmission

The Seasonal End of Human Coronavirus Hospital Admissions with Implications for SARS-CoV-2 (Preprint)

2020 ◽  
Author(s):  
Alan T Evangelista
Keyword(s):  
Hospital Admissions ◽  
Disease Incidence ◽  
Influenza Viruses ◽  
Seasonal Effects ◽  
Human Coronavirus ◽  
Enveloped Virus ◽  
Multiplex Pcr Assay ◽  
Contact Transmission ◽  
Human Coronaviruses

UNSTRUCTURED The seasonality of influenza viruses and endemic human coronaviruses was tracked over an 8-year period to assess key epidemiologic reduction points in disease incidence for an urban area in the northeast United States. Patients admitted to a pediatric hospital with worsening respiratory symptoms were tested using a multiplex PCR assay from nasopharyngeal swabs. The additive seasonal effects of outdoor temperatures and indoor relative humidity (RH) were evaluated. The 8-year average peak activity of human coronaviruses occurred in the first week of January, when droplet and contact transmission was enabled by the low indoor RH of 20-30%. Previous studies have shown that an increase in RH to 50% has been associated with markedly reduced viability and transmission of influenza virus and animal coronaviruses. As disease incidence was reduced by 50% in early March, to 75% in early April, to greater than 99% at the end of April, a relationship was observed from colder temperatures in January with a low indoor RH to a gradual increase in outdoor temperatures in April with an indoor RH of 45-50%. As a lipid-bound, enveloped virus with similar size characteristics to endemic human coronaviruses, SARS-CoV-2 should be subject to the same dynamics of reduced viability and transmission with increased humidity. In addition to the major role of social distancing, the transition from lower to higher indoor RH with increasing outdoor temperatures could have an additive effect on the decrease in SARS-CoV-2 cases in May. Over the 8-year period of this study, human coronavirus activity was either zero or >99% reduction in the months of June through September, and the implication would be that SARS-Cov-2 may follow a similar pattern. INTERNATIONAL REGISTERED REPORT RR2-doi.org/10.1101/2020.05.15.20103416

scholarly journals Stochastic and deterministic mathematical model of cholera disease dynamics with direct transmission

2020 ◽  
Vol 2020 (1) ◽  
Author(s):  
Getachew Teshome Tilahun ◽  
Woldegebriel Assefa Woldegerima ◽  
Aychew Wondifraw
Keyword(s):  
Mathematical Model ◽  
Stochastic Model ◽  
Deterministic Model ◽  
Equilibrium Points ◽  
Invariant Solution ◽  
Stochastic Approach ◽  
Disease Dynamics ◽  
Treatment Rate ◽  
Invariant Region ◽  
Contact Transmission

AbstractIn this paper we develop a stochastic mathematical model of cholera disease dynamics by considering direct contact transmission pathway. The model considers four compartments, namely susceptible humans, infectious humans, treated humans, and recovered humans. Firstly, we develop a deterministic mathematical model of cholera. Since the deterministic model does not consider the randomness process or environmental factors, we converted it to a stochastic model. Then, for both types of models, the qualitative behaviors, such as the invariant region, the existence of a positive invariant solution, the two equilibrium points (disease-free and endemic equilibrium), and their stabilities (local as well as global stability) of the model are studied. Moreover, the basic reproduction numbers are obtained for both models and compared. From the comparison, we obtained that the basic reproduction number of the stochastic model is much smaller than that of the deterministic one, which means that the stochastic approach is more realistic. Finally, we performed sensitivity analysis and numerical simulations. The numerical simulation results show that reducing contact rate, improving treatment rate, and environmental sanitation are the most crucial activities to eradicate cholera disease from the community.

Genetic evolution of Mycoplasma capricolum subsp. capripneumoniae strains and molecular epidemiology of contagious caprine pleuropneumonia by sequencing of locus H2

2002 ◽  
Vol 85 (2) ◽  
pp. 111-123 ◽  
Author(s):  
S Lorenzon ◽  
H Wesonga ◽  
Laikemariam Ygesu ◽  
Tesfaalem Tekleghiorgis ◽  
Y Maikano ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Genetic Evolution ◽  
Mycoplasma Capricolum ◽  
Contagious Caprine Pleuropneumonia

​Caprine Respiratory Mycoplasmosis (Contagious Caprine Pleuropneumonia CCPP)- A Global Perspective of the Disease, Epidemiology, Diagnosis, Chemotherapy and Immunization: A Review

2021 ◽  
Author(s):  
M. Shaheen ◽  
S. Bashir ◽  
N. Hassan ◽  
Z.A. Akhoon ◽  
A. Muhee
Keyword(s):  
Animal Health ◽  
Small Ruminants ◽  
Global Perspective ◽  
Effective Vaccine ◽  
Febrile Reaction ◽  
High Morbidity ◽  
Atypical Pneumonia ◽  
Mycoplasma Infection ◽  
Mycoplasma Capricolum ◽  
Contagious Caprine Pleuropneumonia

Mycoplasma infection of the respiratory tract of goats is prevalent worldwide including the South Asian sub-continent. Owing to intensive and large scale goat farming, the incidence of the disease is on an increase. Among various species of mycoplasma, Mycoplasma capricolum subspecies Capri pneumoniae is increasingly incriminated in Contagious Caprine Pleurapneumonia (CCPP) in goat populations with considerable economic fallout in the form of high morbidity and mortality. The disease manifestations in caprines are recorded as anorexia, high febrile reaction and respiratory embarrassment in the shape of clinical dyspnoea, polypnea, paroxysmal cough and sero-purulent nasal discharges. The disease is thus contracted by the healthy animals through aerosol, contaminated feed and water sources in the herd premises, without a protective immunity and that the conferred immunity in recovered cases being short-lived. The true lesions of CCPP are confined to the lung alveolar tissues of infected goats, which distinguish it from other respiratory diseases of small ruminants caused by the members of the Mycoplasma mycoides cluster. Atypical pneumonia caused by the mycoplasma infection of goats, also known as Contagious Caprine Pleuropneumonia (CCPP) has been more often reported from Africa and Asia than Europe. Classical, acute CCPP attributed to Mycoplasma capricolum subsp. Capri pneumoniae, originally known asthe F38 biotype (World Organisation for Animal Health, 2008) causes heavy kid mortality. Two other organisms in this group, M. mycoides subsp. capri and M. mycoides subsp. mycoides large-colony type, can cause disease in small ruminants that clinico-pathologically mimics CCPP but may have extra pulmonary signs and lesions, sometimes. Mycoplasma Capri pneumoniae and other members of the M. mycoides cluster cross-react in serological tests and share biochemical and genetic similarities. The most favourable epidemiological scenario in the Sub-continent is the hot humid climate during monsoons. The diversity and multi-etiological subspecies involved in the disease is detrimental in the development of an effective vaccine even though in some places a liquid vaccine is presently in use. At other places, anti-mycoplasmal antibiotics of aminoglycoside and fluoroquinolone and perhaps the macrolide groups remain to be the main option in preventing flock mortalities.

Consequences of Migrating U.S. Contagious Facilities Into General Hospitals, 1900–1950

2021 ◽  
pp. 193758672110498
Author(s):  
Jeanne Kisacky
Keyword(s):  
General Hospital ◽  
Disease Incidence ◽  
Spatial Separation ◽  
General Hospitals ◽  
Hospital Facility ◽  
Contagious Disease ◽  
Contact Transmission ◽  
History Of ◽  
Isolation Facilities ◽  
Isolation Facility

Until the 1880s, hospitals excluded contagious disease patients from admission because of the danger they posed to other patients; by the 1950s, contagious disease care had literally moved into the general hospital. This article correlates the changing isolation facility designs with changing disease incidence and prevention strategies. It argues that isolation moved into the hospital in stages that have consequence for isolation facility design today. Between the 1890s and 1940s, contagious disease care shifted from remote isolation hospitals (commonly known as pest houses) to separate contagious disease hospitals, to contagious disease “units” adjacent to or within a general hospital facility, and to isolation rooms included in nursing units. The architectural history of isolation facility designs shows that the integration of isolation facilities into general hospitals relied on the success of new aseptic nursing procedures that prevented contact transmission but which downgraded the need for spatial separation to prevent airborne transmission. In the second half of the 20th century, federal funding and standards made isolation rooms in the hospital the norm. This migration coincided with a historically unprecedented reduction in contagious disease incidence produced by successful vaccines and antibiotics. By the 1980s, the rise of new and antibiotic resistant diseases led to extensive redesigns of the in-house isolation rooms to make them more effective. This article suggests that it is time to rethink isolation not just at the detail level but in terms of its location in relation to the general hospital.

Seroepidemiology and risk factor analysis of contagious caprine pleuropneumonia in Himalayan Pashmina Goats

2019 ◽  
Vol 171 ◽  
pp. 23-36 ◽  
Author(s):  
Oveas Rafiq Parray ◽  
Mohd. Iqbal Yatoo ◽  
Muheet ◽  
Riyaz Ahmed Bhat ◽  
Hamid Ullah Malik ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Risk Factor ◽  
Risk Factor Analysis ◽  
Contagious Caprine Pleuropneumonia

Thermal Elastohydrodynamic Lubrication Analysis for Point Contact Transmission

2009 ◽  
Author(s):  
Hai-zhou Huang ◽  
Xi-chuan Niu ◽  
Xiao-yang Yuan
Keyword(s):  
Film Thickness ◽  
Numerical Solutions ◽  
Point Contact ◽  
Elastohydrodynamic Lubrication ◽  
Surface Velocity ◽  
Squeeze Film ◽  
Elastic Displacement ◽  
Circular Arc ◽  
Tooth Width ◽  
Contact Transmission

To investigate the thermal EHL (elastohydrodynamic lubrication) in point contact transmission, a model considering the two-dimensional surface velocity of tooth face and the running-in is proposed. The numerical solutions for pressure, temperature and film thickness distribution in the contact zone are obtained by solving equations including the Reynolds, Energy and the elastic displacement with variable dimension meshing method. The model was used to study the point contact transmission of the circular arc gear in a windlass. The main results show that it is pure rolling along the direction of tooth width, and the rolling speed plays a leading role in improving the lubricating performance and transmission efficiency of circular arc gear. The squeeze film effect makes the pressure peak tend to be gentle and the film thickness increase slightly.

scholarly journals Experimental infection of domestic dogs and cats with SARS-CoV-2: Pathogenesis, transmission, and response to reexposure in cats

2020 ◽  
Vol 117 (42) ◽  
pp. 26382-26388 ◽  
Author(s):  
Angela M. Bosco-Lauth ◽  
Airn E. Hartwig ◽  
Stephanie M. Porter ◽  
Paul W. Gordy ◽  
Mary Nehring ◽  
...  
Keyword(s):  
Antibody Response ◽  
Acute Infection ◽  
Clinical Signs ◽  
Neutralizing Antibody ◽  
Human Infection ◽  
Vaccine Strategy ◽  
Animal Reservoir ◽  
Viral Shedding ◽  
Contact Transmission ◽  
Infection Resistance

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has reached nearly every country in the world with extraordinary person-to-person transmission. The most likely original source of the virus was spillover from an animal reservoir and subsequent adaptation to humans sometime during the winter of 2019 in Wuhan Province, China. Because of its genetic similarity to SARS-CoV-1, it is probable that this novel virus has a similar host range and receptor specificity. Due to concern for human–pet transmission, we investigated the susceptibility of domestic cats and dogs to infection and potential for infected cats to transmit to naive cats. We report that cats are highly susceptible to infection, with a prolonged period of oral and nasal viral shedding that is not accompanied by clinical signs, and are capable of direct contact transmission to other cats. These studies confirm that cats are susceptible to productive SARS-CoV-2 infection, but are unlikely to develop clinical disease. Further, we document that cats developed a robust neutralizing antibody response that prevented reinfection following a second viral challenge. Conversely, we found that dogs do not shed virus following infection but do seroconvert and mount an antiviral neutralizing antibody response. There is currently no evidence that cats or dogs play a significant role in human infection; however, reverse zoonosis is possible if infected owners expose their domestic pets to the virus during acute infection. Resistance to reinfection holds promise that a vaccine strategy may protect cats and, by extension, humans.

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