Single-dose and steady-state pharmacokinetics of sabeluzole in senile dementia of Alzheimer type patients

1992 ◽  
Vol 43 (6) ◽  
pp. 661-662 ◽  
Author(s):  
P. P. De Deyn ◽  
V. Van de Velde ◽  
W. Verslegers ◽  
J. Saerens ◽  
B. A. Pickut ◽  
...  
Keyword(s):  
Single Dose ◽  
Steady State ◽  
Senile Dementia ◽  
Alzheimer Type ◽  
Dementia Of Alzheimer Type

In vivo exploration of brain phosphorus 31 metabolism in patients with senile dementia of Alzheimer type

1994 ◽  
Vol 9 (2) ◽  
pp. 105-109
Author(s):  
G Mecheri ◽  
Y Bissuel ◽  
J Dalery ◽  
JL Terra ◽  
G Balvay ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Senile Dementia ◽  
Phospholipid Metabolism ◽  
Alzheimer Type ◽  
Dementia Of Alzheimer Type ◽  
Non Invasive ◽  
Significant Difference ◽  
The Brain

SummaryIn vivo NMR 31p spectroscopy is a non invasive, non ionizing method of exploration of energy and phospholipid metabolism in the brain. This study consisted of comparing 31p spectra in five patients with Senile Dementia of Alzheimer Type (SDAT) with those of four controls of similar ages. Abnormal phosphonionocsters (PME) concentrations, either high or low, were found in the patients, but statistical analysis did not elicit any significant difference relative to controls.

scholarly journals Irregular Distortion of The Erythrocytes (Acanthocytes, Spur Cells) in Senile Dementia

1994 ◽  
Vol 12 (1) ◽  
pp. 23-41 ◽  
Author(s):  
H. B. Goodall ◽  
A. H. Reid ◽  
D. J. Findlay ◽  
C. Hind ◽  
J. Kay ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Membrane ◽  
Senile Dementia ◽  
Red Cells ◽  
Alzheimer Type ◽  
Dementia Of Alzheimer Type

An excess of irregularly di storted red cells with spiked forms (acanthocytes. spur cells) has been found in a substantial minority of patient s with seni le dementia of Alzheimer type (7 of 50 patients, 3 of 21 men and 4 of 29 women). Of 100 control patients, 42 men and 58 women), 5 (men and 2 women) showed comparable distortion, but, of these, one man may well have incipient dementia and the others had serious organic di seases which may be associated with comparable erythrocytic changes. The cause of the distortion is not yet clear, but the presence of occasional giant erythrocytes in the absence of general macrocytosis suggests a possible abnormality of cell membrane synthes is. This distortion may be a useful marker in patients with loss of memory. Whether it is a manifestation of a haemopoietic clone or a constitutional anomaly associated with Alzheimer’s disease remains to be seen.

Measures of ageing in senile dementia of Alzheimer type and in controls

1990 ◽  
Vol 5 (5) ◽  
pp. 323-325
Author(s):  
Beryl Shepherd ◽  
Graham J. Naylor ◽  
Anne H. W. Smith ◽  
Ann McHarg ◽  
Margaret Harper
Keyword(s):  
Senile Dementia ◽  
Alzheimer Type ◽  
Dementia Of Alzheimer Type

Monoamine metabolism in senile dementia of Alzheimer type

1983 ◽  
Vol 60 (3) ◽  
pp. 383-392 ◽  
Author(s):  
Alan J. Cross ◽  
Timoty J. Crow ◽  
Julie A. Johnson ◽  
Michael H. Joseph ◽  
Elaine K. Perry ◽  
...  
Keyword(s):  
Senile Dementia ◽  
Alzheimer Type ◽  
Monoamine Metabolism ◽  
Dementia Of Alzheimer Type

scholarly journals A quantitative study of cerebral atrophy in senile dementia of alzheimer type.

1988 ◽  
Vol 25 (5) ◽  
pp. 480-485
Author(s):  
Hitoshi Fukuda ◽  
Masahiro Yoshimura ◽  
Hiroshi Kawasaki ◽  
Hiroshi Yamanouchi ◽  
Shigeki Kuzuhara ◽  
...  
Keyword(s):  
Quantitative Study ◽  
Senile Dementia ◽  
Cerebral Atrophy ◽  
Alzheimer Type ◽  
Dementia Of Alzheimer Type
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