In vivo exploration of brain phosphorus 31 metabolism in patients with senile dementia of Alzheimer type

1994 ◽  
Vol 9 (2) ◽  
pp. 105-109
Author(s):  
G Mecheri ◽  
Y Bissuel ◽  
J Dalery ◽  
JL Terra ◽  
G Balvay ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Senile Dementia ◽  
Phospholipid Metabolism ◽  
Alzheimer Type ◽  
Dementia Of Alzheimer Type ◽  
Non Invasive ◽  
Significant Difference ◽  
The Brain

SummaryIn vivo NMR 31p spectroscopy is a non invasive, non ionizing method of exploration of energy and phospholipid metabolism in the brain. This study consisted of comparing 31p spectra in five patients with Senile Dementia of Alzheimer Type (SDAT) with those of four controls of similar ages. Abnormal phosphonionocsters (PME) concentrations, either high or low, were found in the patients, but statistical analysis did not elicit any significant difference relative to controls.

scholarly journals Irregular Distortion of The Erythrocytes (Acanthocytes, Spur Cells) in Senile Dementia

1994 ◽  
Vol 12 (1) ◽  
pp. 23-41 ◽  
Author(s):  
H. B. Goodall ◽  
A. H. Reid ◽  
D. J. Findlay ◽  
C. Hind ◽  
J. Kay ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Membrane ◽  
Senile Dementia ◽  
Red Cells ◽  
Alzheimer Type ◽  
Dementia Of Alzheimer Type

An excess of irregularly di storted red cells with spiked forms (acanthocytes. spur cells) has been found in a substantial minority of patient s with seni le dementia of Alzheimer type (7 of 50 patients, 3 of 21 men and 4 of 29 women). Of 100 control patients, 42 men and 58 women), 5 (men and 2 women) showed comparable distortion, but, of these, one man may well have incipient dementia and the others had serious organic di seases which may be associated with comparable erythrocytic changes. The cause of the distortion is not yet clear, but the presence of occasional giant erythrocytes in the absence of general macrocytosis suggests a possible abnormality of cell membrane synthes is. This distortion may be a useful marker in patients with loss of memory. Whether it is a manifestation of a haemopoietic clone or a constitutional anomaly associated with Alzheimer’s disease remains to be seen.

Single-dose and steady-state pharmacokinetics of sabeluzole in senile dementia of Alzheimer type patients

1992 ◽  
Vol 43 (6) ◽  
pp. 661-662 ◽  
Author(s):  
P. P. De Deyn ◽  
V. Van de Velde ◽  
W. Verslegers ◽  
J. Saerens ◽  
B. A. Pickut ◽  
...  
Keyword(s):  
Single Dose ◽  
Steady State ◽  
Senile Dementia ◽  
Alzheimer Type ◽  
Dementia Of Alzheimer Type

scholarly journals Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Xavier Hadoux ◽  
Flora Hui ◽  
Jeremiah K. H. Lim ◽  
Colin L. Masters ◽  
Alice Pébay ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Hyperspectral Imaging ◽  
Spectral Difference ◽  
Non Invasive ◽  
Potential Biomarker ◽  
Negative Controls ◽  
The Brain ◽  
Independent Cohort

Abstract Studies of rodent models of Alzheimer’s disease (AD) and of human tissues suggest that the retinal changes that occur in AD, including the accumulation of amyloid beta (Aβ), may serve as surrogate markers of brain Aβ levels. As Aβ has a wavelength-dependent effect on light scatter, we investigate the potential for in vivo retinal hyperspectral imaging to serve as a biomarker of brain Aβ. Significant differences in the retinal reflectance spectra are found between individuals with high Aβ burden on brain PET imaging and mild cognitive impairment (n = 15), and age-matched PET-negative controls (n = 20). Retinal imaging scores are correlated with brain Aβ loads. The findings are validated in an independent cohort, using a second hyperspectral camera. A similar spectral difference is found between control and 5xFAD transgenic mice that accumulate Aβ in the brain and retina. These findings indicate that retinal hyperspectral imaging may predict brain Aβ load.

Measures of ageing in senile dementia of Alzheimer type and in controls

1990 ◽  
Vol 5 (5) ◽  
pp. 323-325
Author(s):  
Beryl Shepherd ◽  
Graham J. Naylor ◽  
Anne H. W. Smith ◽  
Ann McHarg ◽  
Margaret Harper
Keyword(s):  
Senile Dementia ◽  
Alzheimer Type ◽  
Dementia Of Alzheimer Type

Monoamine metabolism in senile dementia of Alzheimer type

1983 ◽  
Vol 60 (3) ◽  
pp. 383-392 ◽  
Author(s):  
Alan J. Cross ◽  
Timoty J. Crow ◽  
Julie A. Johnson ◽  
Michael H. Joseph ◽  
Elaine K. Perry ◽  
...  
Keyword(s):  
Senile Dementia ◽  
Alzheimer Type ◽  
Monoamine Metabolism ◽  
Dementia Of Alzheimer Type
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