An antineoplastic C14-labeled methylhydrazine derivative in P815 mouse leukemia. a metabolic study

1965 ◽  
Vol 21 (5) ◽  
pp. 284-286 ◽  
Author(s):  
W. Kreis ◽  
W. Yen
Keyword(s):  
Metabolic Study ◽  
Mouse Leukemia ◽  
P815 Mouse

Studies on the metabolic fate of the14C-labeled methyl group of a methylhydrazine derivative in P815 mouse leukemia

1966 ◽  
Vol 22 (7) ◽  
pp. 431-433 ◽  
Author(s):  
W. Kreis ◽  
Susan B. Piepho ◽  
Hannah V. Bernhard
Keyword(s):  
Metabolic Fate ◽  
Mouse Leukemia ◽  
Methyl Group ◽  
P815 Mouse

Activation of Cellular Oncogenes in Human and Mouse Leukemia-Lymphomas: Spontaneous and Induced Oncogene Expression in Murine B Lymphocytic Neoplasms

1987 ◽  
Vol 5 (4) ◽  
pp. 345-368 ◽  
Author(s):  
J. Frederic Mushinski ◽  
Wendy Davidson ◽  
Herbert Morse
Keyword(s):  
Mouse Leukemia ◽  
Oncogene Expression ◽  
Cellular Oncogenes ◽  
Human And Mouse

Genetic evidence for a product of the Fv-1 locus that transfers resistance to mouse leukemia viruses.

1976 ◽  
Vol 20 (3) ◽  
pp. 589-596 ◽  
Author(s):  
R W Tennant ◽  
B Schluter ◽  
F E Myer ◽  
J A Otten ◽  
W K Yang ◽  
...  
Keyword(s):  
Genetic Evidence ◽  
Mouse Leukemia ◽  
Leukemia Viruses

scholarly journals A METABOLIC STUDY OF AMYOTONIA CONGENITA

1920 ◽  
Vol 42 (3) ◽  
pp. 581-590
Author(s):  
Mildred R. Ziegler ◽  
N.O. Pearce
Keyword(s):  
Metabolic Study

scholarly journals A METABOLIC STUDY OF α-AMINOBUTYRIC ACID

1949 ◽  
Vol 180 (3) ◽  
pp. 1059-1063
Author(s):  
Marvin D. Armstrong ◽  
Francis Binkley
Keyword(s):  
Aminobutyric Acid ◽  
Metabolic Study

scholarly journals An early enlargement of the putrescine pool is required for growth in L1210 mouse leukemia cells under hypoosmotic stress.

1991 ◽  
Vol 266 (10) ◽  
pp. 6142-6151
Author(s):  
R Poulin ◽  
R S Wechter ◽  
A E Pegg
Keyword(s):  
Leukemia Cells ◽  
Mouse Leukemia ◽  
Hypoosmotic Stress ◽  
L1210 Mouse Leukemia

Assessment of tramadol pharmacokinetics in correlation with CYP2D6 and clinical symptoms

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Mahnaz Ahmadimanesh ◽  
Mehri Bemani Naeini ◽  
Mohammad-Reza Rouini ◽  
Shahin Shadnia ◽  
Mahmoud Ghazi-Khansari
Keyword(s):  
Clinical Symptoms ◽  
Metabolic Ratio ◽  
Nausea And Vomiting ◽  
Extensive Metabolizers ◽  
Metabolic Study ◽  
Blood Samples ◽  
Admission Time ◽  
Cyp2d6 Phenotype ◽  
Urine Concentrations ◽  
Adequate Data

AbstractObjectivesDue to lack of adequate data on tramadol kinetic in relevance of CYP2D6 toxicity, this study was designed to investigate the effect of CYP2D6 phenotype in tramadol poisoning. The saliva, urine and blood samples were taken at the admission time. Consequently, concentration of tramadol and its major metabolites were measured.MethodsA pharmacokinetic and metabolic study was developed in cases of tramadol poisoned (n=96). Cases of tramadol poisoned evidenced seizure, hypertension, dizziness, nausea and vomiting symptoms participated.ResultsFemale cases showed higher N-desmethyltramadol (M2) tramadol concentrations than male cases: in urine (40.12 ± 124.53 vs. 7.3 ± 7.13), saliva (16.91 ± 26.03 vs. 5.89 ± 7.02), and blood (1.11 ± 1.56 vs. 0.3 ± 0.38) samples. Significant correlation between blood, saliva, and urine concentrations were found (r = 0.5). Based on the metabolic ratio of O-desmethyltramadol (M1) of male (0.53 ± 0.22) and female (0.43 ± 0.26), poisoning and severe symptoms like seizure in female occurs statistically fewer (13.04%) than in male (50.6%). Assessment of CYP2D6 phenotype showed all of the participants were extensive metabolizers (EM) and their phenotype was associated with clinical symptoms.ConclusionsAccording to our results, M1 as a high potent metabolite has an important role in toxicity and the likelihood of poisoning in people with EM phenotype. Finally, tramadol metabolic ratio may justify the cause of various symptoms in human tramadol poisoning.

scholarly journals Insight into the Metabolic Profiles of Pb(II) Removing Microorganisms

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4008
Author(s):  
Carla Cilliers ◽  
Evans M. N. Chirwa ◽  
Hendrik G. Brink
Keyword(s):  
Liquid Chromatography ◽  
High Performance ◽  
Microbial Consortium ◽  
Luria Bertani ◽  
Nutrient Concentrations ◽  
Batch Experiments ◽  
Metabolic Study ◽  
Luria Bertani Broth ◽  
Tandem Mass Spectroscopy ◽  
Insight Into

The objective of the study was to gather insight into the metabolism of lead-removing microorganisms, coupled with Pb(II) removal, biomass viability and nitrate concentrations for Pb(II) bioremoval using an industrially obtained microbial consortium. The consortium used for study has proven to be highly effective at removing aqueous Pb(II) from solution. Anaerobic batch experiments were conducted with Luria-Bertani broth as rich growth medium over a period of 33 h, comparing a lower concentration of Pb(II) with a higher concentration at two different nutrient concentrations. Metabolite profiling and quantification were conducted with the aid of both liquid chromatography coupled with tandem mass spectroscopy (UPLC-HDMS) in a “non-targeted” fashion and high-performance liquid chromatography (HPLC) in a “targeted” fashion. Four main compounds were identified, and a metabolic study was conducted on each to establish their possible significance for Pb(II) bioremoval. The study investigates the first metabolic profile to date for Pb(II) bioremoval, which in turn can result in a clarified understanding for development on an industrial and microbial level.

HETEROLOGOUS TRANSPLANTATION OF A MOUSE LEUKEMIA IN THE RAT

1959 ◽  
Vol 24 (1) ◽  
pp. 114-115 ◽  
Author(s):  
JOHN S. THOMPSON ◽  
CLIFFORD W. GURNEY
Keyword(s):  
Mouse Leukemia ◽  
Heterologous Transplantation
Sign in / Sign up

Export Citation Format

Share Document