Immunohistochemical expression of manganese superoxide dismutase in hepatocellular carcinoma, using a specific monoclonal antibody

1994 ◽  
Vol 29 (4) ◽  
pp. 443-449 ◽  
Author(s):  
Yoshi Aida ◽  
Shiro Maeyama ◽  
Toshifumi Takakuwa ◽  
Toshiyuki Uchikoshi ◽  
Yasuo Endo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Monoclonal Antibody ◽  
Superoxide Dismutase ◽  
Manganese Superoxide Dismutase ◽  
Specific Monoclonal Antibody ◽  
Immunohistochemical Expression ◽  
Manganese Superoxide

Manganese Superoxide Dismutase Dimorphism and Iron Overload, Hepatocellular Carcinoma, and Death in Hepatitis C Virus–Infected Patients

2007 ◽  
Vol 5 (5) ◽  
pp. 630-635 ◽  
Author(s):  
Pierre Nahon ◽  
Angela Sutton ◽  
Dominique Pessayre ◽  
Pierre Rufat ◽  
Marianne Ziol ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Superoxide Dismutase ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Iron Overload ◽  
Manganese Superoxide Dismutase ◽  
Manganese Superoxide

Different Roles of Sp Family Members in HIV-1 Tat-Mediated Manganese Superoxide Dismutase Suppression in Hepatocellular Carcinoma Cells

2005 ◽  
Vol 24 (5) ◽  
pp. 299-310 ◽  
Author(s):  
Sureerut Porntadavity ◽  
Avindra Nath ◽  
Virapong Prachayasittikul ◽  
Adela Cota-Gomez ◽  
Sonia C. Flores ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Superoxide Dismutase ◽  
Manganese Superoxide Dismutase ◽  
Family Members ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells ◽  
Manganese Superoxide ◽  
Hiv 1

scholarly journals A Monoclonal Antibody against COOH-terminal Peptide of Human Liver Manganese Superoxide Dismutase

1989 ◽  
Vol 264 (10) ◽  
pp. 5762-5767
Author(s):  
T Kawaguchi ◽  
S Noji ◽  
T Uda ◽  
Y Nakashima ◽  
A Takeyasu ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Superoxide Dismutase ◽  
Human Liver ◽  
Manganese Superoxide Dismutase ◽  
Manganese Superoxide

scholarly journals 17β-Estradiol Promotes Apoptosis of HepG2 Cells Caused by Oxidative Stress by Increasing Foxo3a Phosphorylation

2021 ◽  
Vol 12 ◽  
Author(s):  
Yusheng Guo ◽  
Xiangsheng Cai ◽  
Hanwei Lu ◽  
Qiqi Li ◽  
Ying Zheng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Hepatocellular Carcinoma ◽  
Superoxide Dismutase ◽  
Hepg2 Cells ◽  
Manganese Superoxide Dismutase ◽  
Manganese Superoxide ◽  
B Virus ◽  
17Β Estradiol ◽  
New Treatment

Liver cancer is associated with high mortality, particularly in patients infected with the hepatitis B virus. Treatment methods remain very limited. Here, we explored the effects of 17β-estradiol (E2) on apoptosis of various liver cell lines (LO2, HepG2, and HepG2.2.15 cells). Within a certain concentration range, 17β-estradiol induced oxidative stress and apoptosis of HepG2 cells, downregulated ERα-36 expression, and increased Akt and Foxo3a phosphorylation. p-Foxo3a became localized around the nucleus but did not enter the organelle. The levels of mRNAs encoding manganese superoxide dismutase (MnSOD) and catalase, to the promoters of which Foxo3a binds to trigger gene expression, were significantly reduced in HepG2 cells. 17β-estradiol had no obvious effects on LO2 or HepG2.2.15 cells. We speculate that 17β-estradiol may induce oxidative stress in HepG2 cells by increasing Foxo3a phosphorylation, thus promoting apoptosis. This may serve as a new treatment for hepatocellular carcinoma.

Manganese superoxide dismutase activity and incidence of hepatocellular carcinoma in patients with Child?Pugh class A liver cirrhosis: a 7-year follow-up study

2007 ◽  
Vol 27 (6) ◽  
pp. 791-797 ◽  
Author(s):  
Caterina Clemente ◽  
Silvana Elba ◽  
Gianpiero Buongiorno ◽  
Vito Guerra ◽  
Benedetta D'Attoma ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Superoxide Dismutase ◽  
Liver Cirrhosis ◽  
Manganese Superoxide Dismutase ◽  
Superoxide Dismutase Activity ◽  
Follow Up Study ◽  
Class A ◽  
Manganese Superoxide ◽  
Pugh Class

Reactivity of a monoclonal antibody to manganese superoxide dismutase with human ovarian carcinoma

1990 ◽  
Vol 9 ◽  
pp. 171 ◽  
Author(s):  
Mutsuo Ishikawa ◽  
Toshiyuki Nakata ◽  
Tetsuya Shimizu ◽  
Tetsuo Kawaguchi ◽  
Teizo Uda ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Superoxide Dismutase ◽  
Ovarian Carcinoma ◽  
Manganese Superoxide Dismutase ◽  
Manganese Superoxide ◽  
Human Ovarian Carcinoma
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