Nucleosome unit repeat size in aneuploid mice

1990 ◽  
Vol 28 (7-8) ◽  
pp. 389-397 ◽  
Author(s):  
A. V. Rake
Keyword(s):  
Repeat Size ◽  
Unit Repeat

scholarly journals Tandem Repeats in Bacillus: Unique Features and Taxonomic Distribution

2021 ◽  
Vol 22 (10) ◽  
pp. 5373
Author(s):  
Juan A. Subirana ◽  
Xavier Messeguer
Keyword(s):  
Tandem Repeats ◽  
Bacterial Species ◽  
Individual Species ◽  
Large Set ◽  
Bacterial Genomes ◽  
Rna Molecules ◽  
Variable Sequence ◽  
Repeat Size ◽  
Genomic Studies ◽  
Dna Tandem Repeats

Little is known about DNA tandem repeats across prokaryotes. We have recently described an enigmatic group of tandem repeats in bacterial genomes with a constant repeat size but variable sequence. These findings strongly suggest that tandem repeat size in some bacteria is under strong selective constraints. Here, we extend these studies and describe tandem repeats in a large set of Bacillus. Some species have very few repeats, while other species have a large number. Most tandem repeats have repeats with a constant size (either 52 or 20–21 nt), but a variable sequence. We characterize in detail these intriguing tandem repeats. Individual species have several families of tandem repeats with the same repeat length and different sequence. This result is in strong contrast with eukaryotes, where tandem repeats of many sizes are found in any species. We discuss the possibility that they are transcribed as small RNA molecules. They may also be involved in the stabilization of the nucleoid through interaction with proteins. We also show that the distribution of tandem repeats in different species has a taxonomic significance. The data we present for all tandem repeats and their families in these bacterial species will be useful for further genomic studies.

scholarly journals ASFMR1splice variant

2018 ◽  
Vol 4 (4) ◽  
pp. e246 ◽  
Author(s):  
Padmaja Vittal ◽  
Shrikant Pandya ◽  
Kevin Sharp ◽  
Elizabeth Berry-Kravis ◽  
Lili Zhou ◽  
...  
Keyword(s):  
Mental Retardation ◽  
Splice Variant ◽  
Messenger Rna ◽  
Clinical Symptoms ◽  
Fragile X ◽  
Cgg Repeat ◽  
Men And Women ◽  
Fragile X Mental Retardation ◽  
Repeat Size ◽  
Ataxia Syndrome

ObjectiveTo explore the association of a splice variant of theantisense fragile X mental retardation 1(ASFMR1) gene, loss offragile X mental retardation 1(FMR1) AGG interspersions andFMR1CGG repeat size with manifestation, and severity of clinical symptoms of fragile X-associated tremor/ataxia syndrome (FXTAS).MethodsPremutation carriers (PMCs) with FXTAS, without FXTAS, and normal controls (NCs) had a neurologic evaluation and collection of skin and blood samples. Expression ofASFMR1transcript/splice variant 2 (ASFMR1-TV2), nonsplicedASFMR1, totalASFMR1, andFMR1messenger RNA were quantified and compared using analysis of variance. Least absolute shrinkage and selection operator (LASSO) logistic regression and receiver operating characteristic analyses were performed.ResultsPremutation men and women both with and without FXTAS had higherASFMR1-TV2 levels compared with NC men and women (n = 135,135,p< 0.0001), andASFMR1-TV2 had good discriminating power for FXTAS compared with NCs but not for FXTAS from PMC. After adjusting for age, loss of AGG, larger CGG repeat size (in men), and elevatedASFMR1-TV2 level (in women) were strongly associated with FXTAS compared with NC and PMC (combined).ConclusionsThis study found elevated levels ofASFMR1-TV2and loss of AGG interruptions in both men and women with FXTAS. Future studies will be needed to determine whether these variables can provide useful diagnostic or predictive information.

scholarly journals Fragile X premutation carriers with mid-range CGG repeat size and reduction in AGG interruptions demonstrate more profoundly diminished ovarian reserve

2017 ◽  
Vol 108 (3) ◽  
pp. e54
Author(s):  
J. Lekovich ◽  
L. Man ◽  
K. Xu ◽  
D. Lilienthal ◽  
N. Pereira ◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Fragile X ◽  
Diminished Ovarian Reserve ◽  
Cgg Repeat ◽  
Fragile X Premutation ◽  
Repeat Size ◽  
Agg Interruptions

Relation of cardiac abnormalities and CTG-repeat size in myotonic dystrophy

2002 ◽  
Vol 59 (5) ◽  
pp. 350-355 ◽  
Author(s):  
J Finsterer ◽  
E Gharehbaghi-Schnell ◽  
C Stöllberger ◽  
K Fheodoroff ◽  
A Seiser
Keyword(s):  
Myotonic Dystrophy ◽  
Cardiac Abnormalities ◽  
Repeat Size ◽  
Ctg Repeat

How much expansion to be diseased?: Toward repeat size and myotonic dystrophy type 2

Neurology ◽  
2009 ◽  
Vol 72 (6) ◽  
pp. 484-485 ◽  
Author(s):  
B. Schoser ◽  
T. Ashizawa
Keyword(s):  
Myotonic Dystrophy ◽  
Myotonic Dystrophy Type ◽  
Myotonic Dystrophy Type 2 ◽  
Repeat Size

Cloning of a DNA repeat element from horse: DNA sequence and chromosomal localization

Genome ◽  
1995 ◽  
Vol 38 (6) ◽  
pp. 1132-1138 ◽  
Author(s):  
T. E. Broad ◽  
P. E. Lewis ◽  
P. D. Pearce ◽  
S. H. Phua ◽  
J. W. Forrest ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Dna Fingerprinting ◽  
Parentage Analysis ◽  
Repeat Element ◽  
Nucleotide Sequencing ◽  
Dna Repeat ◽  
Multilocus Dna Fingerprinting ◽  
Repeat Dna ◽  
Unit Repeat

A DNA repeat element, revealed initially by digestion of horse DNA with TaqI, was cloned and characterized by Southern and in situ hybridization studies and nucleotide sequencing. The clone, e4/1, consisted of 32 tandem reiterations of a unit repeat of 21–22 bp, and produced multilocus DNA fingerprinting profiles that were useful for parentage analysis in horses. The tandem repeat element was shown by in situ hybridization to be localized in the centromeres of the acrocentric but not metacentric classes of horse chromosomes.Key words: Equidae, Equus caballus, DNA repeat, DNA fingerprinting, centromere.

Atrophy of the cerebellum and brainstem in dentatorubral pallidoluysian atrophy: Influence of CAG repeat size on MRI findings

Neurology ◽  
1997 ◽  
Vol 49 (6) ◽  
pp. 1605-1612 ◽  
Author(s):  
R. Koide ◽  
O. Onodera ◽  
T. Ikeuchi ◽  
R. Kondo ◽  
H. Tanaka ◽  
...  
Keyword(s):  
Cag Repeat ◽  
Mri Findings ◽  
Repeat Size

scholarly journals 173: Ethnic variability in FMR1 CGG repeat size distribution predicts differences in inter-ethnic fragile X syndrome incidence

2016 ◽  
Vol 214 (1) ◽  
pp. S109-S110
Author(s):  
Gabriel A. Lazarin ◽  
Imran S. Haque ◽  
Kenny Wong ◽  
James Goldberg
Keyword(s):  
Size Distribution ◽  
Fragile X Syndrome ◽  
Fragile X ◽  
Cgg Repeat ◽  
Repeat Size ◽  
Ethnic Variability

scholarly journals Androgen Receptor CAG Repeat Size is Associated with Stress Fracture Risk: A Pilot Study

2011 ◽  
Vol 469 (10) ◽  
pp. 2925-2931 ◽  
Author(s):  
Ran Yanovich ◽  
Roni Milgrom ◽  
Eitan Friedman ◽  
Daniel S. Moran
Keyword(s):  
Androgen Receptor ◽  
Pilot Study ◽  
Fracture Risk ◽  
Stress Fracture ◽  
Cag Repeat ◽  
Repeat Size
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