Calcium supplementation affects bone collagen degradation in post-menopausal women with low dietary calcium intake

1996 ◽  
Vol 6 (S1) ◽  
pp. 270-270
Author(s):  
S. Kamel ◽  
M. Brazier ◽  
P. Fardellone ◽  
Y. Rigault ◽  
JP Berrou ◽  
...  
Keyword(s):  
Calcium Intake ◽  
Calcium Supplementation ◽  
Dietary Calcium ◽  
Collagen Degradation ◽  
Bone Collagen ◽  
Dietary Calcium Intake ◽  
Menopausal Women ◽  
Post Menopausal

scholarly journals Dietary Calcium Intake and Calcium Supplementation in Hungarian Patients with Osteoporosis

2013 ◽  
Vol 2013 ◽  
pp. 1-8
Author(s):  
Gábor Speer ◽  
Pál Szamosujvári ◽  
Péter Dombai ◽  
Katalin Csóré ◽  
Kinga Mikófalvi ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Calcium Intake ◽  
Calcium Supplementation ◽  
Dietary Calcium ◽  
Dietary Calcium Intake ◽  
Current Recommendation ◽  
High Calcium Intake ◽  
Osteoporosis Therapy ◽  
Average Intake ◽  
High Calcium

Purpose. Adequate calcium intake is the basis of osteoporosis therapy—when this proves insufficient, even specific antiosteoporotic agents cannot exert their actions properly.Methods. Our representative survey analyzed the dietary intake and supplementation of calcium in 8033 Hungarian female and male (mean age: 68 years) (68.01 (CI95: 67.81–68.21)) patients with osteoporosis.Results. Mean intake from dietary sources was665±7.9 mg (68.01 (CI95: 67.81–68.21)) daily. A significant positive relationship could be detected between total dietary calcium intake and lumbar spine BMD (P=0.045), whereas such correlation could not be demonstrated with femoralT-score. Milk consumption positively correlated with femur (P=0.041), but not with lumbar BMD. The ingestion of one liter of milk daily increased theT-score by 0.133. Average intake from supplementation was558±6.2 mg (68.01 (CI95: 67.81–68.21)) daily. The cumulative dose of calcium—from both dietary intake and supplementation—was significantly associated with lumbar (r=0.024,P=0.049), but not with femur BMD (r=0.021,P=0.107). The currently recommended 1000–1500 mg total daily calcium intake was achieved in 34.5% of patients only. It was lower than recommended in 47.8% of the cases and substantially higher in 17.7% of subjects.Conclusions. We conclude that calcium intake in Hungarian osteoporotic patients is much lower than the current recommendation, while routinely applied calcium supplementation will result in inappropriately high calcium intake in numerous patients.

Dietary calcium, defective cellular Ca2+ handling, and arterial pressure control

1994 ◽  
Vol 72 (8) ◽  
pp. 937-944 ◽  
Author(s):  
David A. McCarron ◽  
Daniel Hatton ◽  
Jean-Baptiste Roullet ◽  
Chantal Roullet
Keyword(s):  
Blood Pressure ◽  
Clinical Trials ◽  
Calcium Intake ◽  
Inverse Relationship ◽  
Spontaneously Hypertensive Rat ◽  
Calcium Supplementation ◽  
Dietary Calcium ◽  
Calcium Handling ◽  
Dietary Calcium Intake ◽  
Experimental Hypertension

The association between dietary calcium intake, calcium metabolism, and blood pressure form the basis of this review. Epidemiologic data consistently show an inverse relationship between dietary calcium and blood pressure. Clinical trials of calcium supplementation have not been as consistent in outcome. Approximately two-thirds of the supplementation studies have found a beneficial effect of calcium on blood pressure. The lack of consistency in outcome from the clinical trials relative to the epidemiological literature may be related to calcium intake. The epidemiological literature indicates an inverse relationship between calcium intake and blood pressure, with those individuals with the lowest calcium intake (< 700 mg/day) having the highest blood pressure. Clinical studies utilizing patients with high baseline calcium levels (> 700 mg/day) may not see an effect of calcium supplementation on blood pressure because of a ceiling effect. Supplemental calcium appears to correct a defect in calcium handling characterized by a renal calcium leak, increased circulating parathroid hormone, and increased intracellular calcium levels. In part, the deficit in cellular calcium homeostasis may be a consequence of abnormal calmodulin activity. Specifically, it appears that calmodulin activity is diminished in experimental hypertension and that increasing dietary calcium may improve calmodulin activity in the spontaneously hypertensive rat. The deficit in calmodulin activity has the potential to interfere with a number of cellular processes crucial to the regulation of cell function and maintenance of appropriate vascular tone. It is concluded that additional research should be directed toward understanding the ramifications of altered calmodulin activity in hypertension and the influence that dietary calcium can have on the activity of calmodulin.Key words: hypertension, dietary Ca2+, calmodulin, Ca2+ metabolism, calcium channel blockers.

scholarly journals Biochemical effects of calcium supplementation in postmenopausal women: influence of dietary calcium intake

1998 ◽  
Vol 67 (6) ◽  
pp. 1273-1278 ◽  
Author(s):  
P Fardellone ◽  
M Brazier ◽  
S Kamel ◽  
J Guéris ◽  
A M Graulet ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Calcium Intake ◽  
Calcium Supplementation ◽  
Dietary Calcium ◽  
Dietary Calcium Intake ◽  
Biochemical Effects

Biological effects of a calcium supplementation in post menopausal women: effects of vitamin d status and dietary calcium

1996 ◽  
Vol 6 (S1) ◽  
pp. 270-270
Author(s):  
P. Fardellone ◽  
M. Brazier ◽  
JP. Berrou ◽  
G. Badot ◽  
J. Guéris ◽  
...  
Keyword(s):  
Vitamin D ◽  
Calcium Supplementation ◽  
Biological Effects ◽  
Dietary Calcium ◽  
Vitamin D Status ◽  
Menopausal Women ◽  
Post Menopausal
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