Detection of lithocholic acid in multiple sclerosis brain tissue

Lipids ◽  
1970 ◽  
Vol 5 (6) ◽  
pp. 578-580 ◽  
Author(s):  
S. H. Mujtaba Naqvi ◽  
Robert B. Ramsey ◽  
H. J. Nicholas
Keyword(s):  
Multiple Sclerosis ◽  
Brain Tissue ◽  
Lithocholic Acid

Acute and chronic synaptic pathology in multiple sclerosis gray matter

2021 ◽  
pp. 135245852110221
Author(s):  
Marco Vercellino ◽  
Stella Marasciulo ◽  
Silvia Grifoni ◽  
Elena Vallino-Costassa ◽  
Chiara Bosa ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Tissue ◽  
Gray Matter ◽  
Axonal Loss ◽  
Strong Indication ◽  
Synaptic Loss ◽  
Synaptic Density ◽  
Synaptic Pathology ◽  
Gabaergic Synapses ◽  
And Control

Objectives: To investigate the extent of synaptic loss, and the contribution of gray matter (GM) inflammation and demyelination to synaptic loss, in multiple sclerosis (MS) brain tissue. Methods: This study was performed on two different post-mortem series of MS and control brains, including deep GM and cortical GM. MS brain samples had been specifically selected for the presence of active demyelinating GM lesions. Over 1,000,000 individual synapses were identified and counted using confocal microscopy, and further characterized as glutamatergic/GABAergic. Synaptic counts were also correlated with neuronal/axonal loss. Results: Important synaptic loss was observed in active demyelinating GM lesions (−58.9%), while in chronic inactive GM lesions, synaptic density was only mildly reduced compared to adjacent non-lesional gray matter (NLGM) (−12.6%). Synaptic loss equally affected glutamatergic and GABAergic synapses. Diffuse synaptic loss was observed in MS NLGM compared to control GM (−21.2% overall). Conclusion: This study provides evidence, in MS brain tissue, of acute synaptic damage/loss during active GM inflammatory demyelination and of synaptic reorganization in chronically demyelinated GM, affecting equally glutamatergic and GABAergic synapses. Furthermore, this study provides a strong indication of widespread synaptic loss in MS NLGM also independently from focal GM demyelination.

Detection of Herpesviridae in postmortem multiple sclerosis brain tissue and controls by polymerase chain reaction

1996 ◽  
Vol 2 (4) ◽  
pp. 249-258 ◽  
Author(s):  
Virginia J Sanders ◽  
Stephen Felisan ◽  
Aimee Waddell ◽  
Wallace W Tourtellotte
Keyword(s):  
Multiple Sclerosis ◽  
Polymerase Chain Reaction ◽  
Brain Tissue ◽  
Chain Reaction ◽  
Polymerase Chain

T1/T2 ratio: A quantitative sensitive marker of brain tissue integrity in multiple sclerosis

2021 ◽  
Author(s):  
Salem Hannoun ◽  
Gabriel Kocevar ◽  
Pekes Codjia ◽  
Berardino Barile ◽  
Francois Cotton ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Tissue ◽  
Tissue Integrity ◽  
Sensitive Marker

Herpesviruses in active plaques of postmortem multiple sclerosis brain tissue

1995 ◽  
Vol 56-63 ◽  
pp. 21-21
Author(s):  
W.W. Tourtellotte ◽  
V.J. Sanders ◽  
A.E. Waddell ◽  
S.L. Felisan ◽  
X. Li ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Tissue

scholarly journals Evaluating the Effects of White Matter Multiple Sclerosis Lesions on the Volume Estimation of 6 Brain Tissue Segmentation Methods

2015 ◽  
Vol 36 (6) ◽  
pp. 1109-1115 ◽  
Author(s):  
S. Valverde ◽  
A. Oliver ◽  
Y. Díez ◽  
M. Cabezas ◽  
J.C. Vilanova ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Brain Tissue ◽  
Volume Estimation ◽  
Tissue Segmentation ◽  
Brain Tissue Segmentation ◽  
Segmentation Methods
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