Urinary excretion of beta-2-microglobulin in patients with active metabolic stone disease

1989 ◽  
Vol 21 (4) ◽  
pp. 381-387 ◽  
Author(s):  
D. Musialik
Keyword(s):  
Urinary Excretion ◽  
Stone Disease ◽  
Beta 2 ◽  
Beta 2 Microglobulin

Effects of Probenecid on Renal Function in Surgical Patients Anesthetized with Low-flow Sevoflurane

2001 ◽  
Vol 94 (1) ◽  
pp. 21-31 ◽  
Author(s):  
Hideyuki Higuchi ◽  
Hiroki Wada ◽  
Yumi Usui ◽  
Kohichiro Goto ◽  
Masuyuki Kanno ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Biochemical Markers ◽  
High Flow ◽  
Surgical Patients ◽  
Low Flow ◽  
Sevoflurane Anesthesia ◽  
Compound A ◽  
Significant Difference ◽  
Beta 2 ◽  
Beta 2 Microglobulin

Background Dehydrofluorination of sevoflurane by carbon dioxide absorbents in anesthesia machines produces compound A, which is nephrotoxic in rats. Several clinical studies indicate that prolonged low-flow sevoflurane anesthesia is associated with an increased urinary excretion of biochemical markers, such as protein. Probenecid, a competitive inhibitor of organic anion transport, diminishes compound A nephrotoxicity in rats. The purpose of the present study was to examine the effects of low- and high-flow sevoflurane anesthesia on urinary excretion of biochemical markers in humans and to examine the effects of probenecid on urinary excretion of these markers. Methods Elective surgical patients (n = 64) were assigned to four groups (n = 16 each): low-flow sevoflurane plus probenecid (LSP), low-flow sevoflurane (LS), high-flow sevoflurane plus probenecid (HSP), and high-flow sevoflurane (HS). Probenecid (2.0 g) was administered orally 2 h before the induction of anesthesia in both the LSP and HSP groups. Nothing was administered orally 2 h before the induction of anesthesia in either the LS or HS groups. All patients underwent prolonged low-flow (1 l/min) or high-flow (6 l/min) sevoflurane anesthesia. Urinary excretion of protein, albumin, beta(2)-microglobulin, glucose, and N-acetyl-beta-d-glucosaminidase was measured for up to 7 days postoperatively. Results Sevoflurane doses were similar in all four groups. There were no differences in blood urea nitrogen, creatinine, or creatinine clearance among the four groups after anesthesia. Average values for urinary excretion of protein, beta(2)-microglobulin, and N-acetyl-beta-d-glucosaminidase in the LS group were significantly higher than those in the other groups (LSP, HSP, HS; P < 0.05). There was no significant difference between the LS and LSP groups in average values for urinary excretion of albumin and glucose, although there were significant differences between the LS and both high-flow sevoflurane groups (HSP, HS). Conclusions Low-flow sevoflurane, which produces a sevenfold higher compound A exposure than high-flow sevoflurane, resulted in significant increases of several biochemical markers in half of the patients. Probenecid appears to provide protection against these renal effects.

scholarly journals URINARY EXCRETION OF BETA-2-MICROGLOBULIN IN CHILDREN WITH URINARY TRACT INFECTIONS

1989 ◽  
Vol 26 (5) ◽  
pp. 505-505 ◽  
Author(s):  
N Korpal-Szczyrska ◽  
M Uszycia-Karcz ◽  
P Mierzewski
Keyword(s):  
Urinary Tract ◽  
Urinary Excretion ◽  
Urinary Tract Infections ◽  
Beta 2 ◽  
Beta 2 Microglobulin ◽  
Tract Infections

Beta-2 Microglobulin in Patients on Peritoneal Dialysis and Hemodialysis

1989 ◽  
Vol 9 (1) ◽  
pp. 37-40 ◽  
Author(s):  
Antonio Scalamogna ◽  
Enrico Imbasciati' ◽  
Amedeo De Vecchi ◽  
Claudia Castelnovo ◽  
Bruno Pagliari' ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Urinary Excretion ◽  
Urine Output ◽  
Serum Levels ◽  
Chronic Dialysis ◽  
Serum Concentrations ◽  
Residual Urine ◽  
Beta 2 ◽  
Beta 2 Microglobulin ◽  
Chronic Ambulatory Peritoneal Dialysis

Serum β2 microglobulin ( β2μ) levels were determined in 62 patients on chronic dialysis, divided according to the type of dialysis-cuprophane hemodialysis, chronic ambulatory peritoneal dialysis (CAPD), or CAPD staned after 76 ± 47 months on cuprophane hemodialysis-and to residual urine output greater than 400 mLlday or less than 10 mL/day. In addition, for patients on CAPD, peritoneal excretion, peritoneal clearance, and urinary excretion of the protein were determined. In anuric patients serum β2μ levels were significantly higher in HD than in CAPD. In patients with residual urine output, serum concentrations of the microprotein were similar in HD and in CAPD. Significant differences were observed in β2μ serum levels and peritoneal clearances in patients switched to CAPD from hemodialysis as compared to those staning with CAPD. Peritoneal clearances of the microprotein was slightly and non-significantly greater in patients with urine output than in anuric patients.

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