Urinary excretion of albumin and beta-2-microglobulin in hypertensive and normotensive renal transplant recipients during urinary diluting and concentrating tests

1986 ◽  
Vol 46 (7) ◽  
pp. 609-614 ◽  
Author(s):  
B. Jespersen ◽  
E. B. Pedersen ◽  
H. Danielsen ◽  
H. J. Kornerup ◽  
F. Knudsen ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Urinary Excretion ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Beta 2 ◽  
Beta 2 Microglobulin

SERUM BETA 2-MICROGLOBULIN MONITORING IN CYCLOSPORINE TREATED RENAL TRANSPLANT RECIPIENTS

1999 ◽  
Vol 67 (7) ◽  
pp. S82 ◽  
Author(s):  
Daniel P. Lange ◽  
Zachary C. Schmittling ◽  
Timothy P. O'Connor
Keyword(s):  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Beta 2 ◽  
Beta 2 Microglobulin

Beta-2-Microglobulin for Differentiation between Ciclosporin A Nephrotoxicity and Graft Rejection in Renal Transplant Recipients

Nephron ◽  
1989 ◽  
Vol 51 (3) ◽  
pp. 330-337 ◽  
Author(s):  
Friedrich Prischl ◽  
Franz Gremmel ◽  
Michael Schwabe ◽  
Johann Schindler ◽  
Peter Balcke ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Graft Rejection ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Ciclosporin A ◽  
Beta 2 ◽  
Beta 2 Microglobulin

scholarly journals No effect of dietary fish oil on renal hemodynamics, tubular function, and renal functional reserve in long-term renal transplant recipients.

1995 ◽  
Vol 5 (7) ◽  
pp. 1434-1440
Author(s):  
J M Hansen ◽  
H Løkkegaard ◽  
C E Høy ◽  
N Fogh-Andersen ◽  
N V Olsen ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Fish Oil ◽  
Dietary Supplementation ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Functional Reserve ◽  
Renal Functional Reserve ◽  
Beta 2 ◽  
Beta 2 Microglobulin

Dietary supplementation with fish oil rich in n-3 polyunsaturated fatty acids has been suggested to protect the kidney against cyclosporin A (CsA) toxicity. This study investigated the effects of a 10-wk dietary supplementation with fish oil on renal function and renal functional reserve in healthy volunteers (N = 9) and two groups of stable long-term kidney-transplanted patients treated with maintenance low-dose CsA (3.0 +/- 0.6 mg/kg; N = 9) or without CsA (N = 9). After an overnight fast, the subjects were water loaded, and clearance studies were performed, postponing morning medication. GFR and effective RPF were measured as the renal clearances of (99mTc)DTPA and (131I)hippuran, respectively. Renal tubular function was evaluated by use of the renal clearance of lithium and the urinary excretion of beta 2-microglobulin. Fish oil did not change baseline values of effective RPF, GFR, lithium clearance, and urinary excretion of beta 2-microglobulin in any of the groups. The infusion of amino acids induced a comparable increase in GFR, lithium clearance, and the urinary excretion rate of beta 2-microglobulin in all three groups with no additional effect of fish oil. Thus, long-term renal transplant recipients treated with a low maintenance dose of CsA had a well-preserved renal functional reserve, and dietary supplementation with fish oil in these patients did not improve renal function.

Urinary Excretion of Kidney Injury Molecule -1 in Renal Transplant Recipients

2012 ◽  
Vol 94 (10S) ◽  
pp. 1166
Author(s):  
S. Kesiraju ◽  
P. Paritala ◽  
C. Uma Maheswara Rao ◽  
A. S. Murthy ◽  
V. S. Reddy ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Urinary Excretion ◽  
Kidney Injury ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Kidney Injury Molecule 1

scholarly journals Urinary Excretion of N1-methyl-2-pyridone-5-carboxamide and N1-methylnicotinamide in Renal Transplant Recipients and Donors

2020 ◽  
Vol 9 (2) ◽  
pp. 437 ◽  
Author(s):  
Carolien P. J. Deen ◽  
Anna van der Veen ◽  
António W. Gomes-Neto ◽  
Johanna M. Geleijnse ◽  
Karin J. Borgonjen-van den Berg ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Nutritional Status ◽  
Urinary Excretion ◽  
Kidney Function ◽  
Density Lipoprotein ◽  
Kidney Donation ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Cross Sectional ◽  
Kidney Donors

N1-methylnicotinamide (N1-MN) and N1-methyl-2-pyridone-5-carboxamide (2Py) are successive end products of NAD+ catabolism. N1-MN excretion in 24-h urine is the established biomarker of niacin nutritional status, and recently shown to be reduced in renal transplant recipients (RTR). However, it is unclear whether 2Py excretion is increased in this population, and, if so, whether a shift in excretion of N1-MN to 2Py can be attributed to kidney function. Hence, we assessed the 24-h urinary excretion of 2Py and N1-MN in RTR and kidney donors before and after kidney donation, and investigated associations of the urinary ratio of 2Py to N1-MN (2Py/N1-MN) with kidney function, and independent determinants of urinary 2Py/N1-MN in RTR. The urinary excretion of 2Py and N1-MN was measured in a cross-sectional cohort of 660 RTR and 275 healthy kidney donors with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Linear regression analyses were used to investigate associations and determinants of urinary 2Py/N1-MN. Median 2Py excretion was 178.1 (130.3–242.8) μmol/day in RTR, compared to 155.6 (119.6–217.6) μmol/day in kidney donors (p < 0.001). In kidney donors, urinary 2Py/N1-MN increased significantly after kidney donation (4.0 ± 1.4 to 5.2 ± 1.5, respectively; p < 0.001). Smoking, alcohol consumption, diabetes, high-density lipoprotein (HDL), high-sensitivity C-reactive protein (hs-CRP) and estimated glomerular filtration rate (eGFR) were identified as independent determinants of urinary 2Py/N1-MN in RTR. In conclusion, the 24-h urinary excretion of 2Py is higher in RTR than in kidney donors, and urinary 2Py/N1-MN increases after kidney donation. As our data furthermore reveal strong associations of urinary 2Py/N1-MN with kidney function, interpretation of both N1-MN and 2Py excretion may be recommended for assessment of niacin nutritional status in conditions of impaired kidney function.

Increased urinary excretion of transforming growth factor-β1 in renal transplant recipients during cytomegalovirus infection

2006 ◽  
Vol 15 (3) ◽  
pp. 217-221 ◽  
Author(s):  
Ilkka Helanterä ◽  
Anna-Maija Teppo ◽  
Petri Koskinen ◽  
Tom Törnroth ◽  
Carola Grönhagen-Riska ◽  
...  
Keyword(s):  
Growth Factor ◽  
Renal Transplant ◽  
Urinary Excretion ◽  
Cytomegalovirus Infection ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals Urinary Excretion of 6-Sulfatoxymelatonin, the Main Metabolite of Melatonin, and Mortality in Stable Outpatient Renal Transplant Recipients

2020 ◽  
Vol 9 (2) ◽  
pp. 525 ◽  
Author(s):  
Anna van der Veen ◽  
Isidor Minović ◽  
Martijn van Faassen ◽  
Antόnio W. Gomes-Neto ◽  
Stefan P. Berger ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renal Disease ◽  
Urinary Excretion ◽  
Cox Regression ◽  
Renal Transplant Recipients ◽  
Healthy Controls ◽  
Transplant Recipients ◽  
Stage Renal Disease ◽  
End Stage

Melatonin is a multifaceted hormone which rises upon the onset of darkness. Pineal synthesis of melatonin is known to be disturbed in patients with end-stage renal disease, but it is not known if its production is restored to normal after successful renal transplantation. We hypothesized that urinary excretion of 6-sulfatoxymelatonin, the major metabolite of melatonin, is lower in renal transplant recipients (RTRs) compared to healthy controls and that this is associated with excess mortality. Urinary 6-sulfatoxymelatonin was measured via LC-MS/MS in 701 stable outpatient RTRs and 285 healthy controls. Median urinary 6-sulfatoxymelatonin in RTR was 13.2 nmol/24 h, which was 47% lower than in healthy controls. Urinary 6-sufatoxymelatonin appeared undetectable in the majority of 36 RTRs with diabetic nephropathy as primary renal disease. Therefore, this subgroup was excluded from further analyses. Of the remaining 665 RTRs, during 5.4 years of follow-up, 110 RTRs died, of whom 38 died due to a cardiovascular cause. In Cox-regression analyses, urinary 6-sulfatoxymelatonin was significantly associated with all-cause mortality (0.60 (0.44–0.81), p = 0.001) and cardiovascular mortality (0.49 (0.29–0.84), p = 0.009), independent of conventional risk factors and kidney function parameters. Based on these results, evaluation and management of melatonin metabolism could be considered for improvement of long-term outcomes in RTRs.

scholarly journals High Urinary Excretion of Kidney Injury Molecule-1 Is an Independent Predictor of Graft Loss in Renal Transplant Recipients

2007 ◽  
Vol 84 (12) ◽  
pp. 1625-1630 ◽  
Author(s):  
Mirjan M. van Timmeren ◽  
Vishal S. Vaidya ◽  
Rutger M. van Ree ◽  
Leendert H. Oterdoom ◽  
Aiko P. J. de Vries ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Urinary Excretion ◽  
Independent Predictor ◽  
Graft Loss ◽  
Kidney Injury ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
High Urinary Excretion ◽  
Kidney Injury Molecule 1
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