Fatty acid oxidation as a function of substrate concentration and of fatty acid-albumin ratio in a working rat heart preparation

1982 ◽  
Vol 394 (S1) ◽  
pp. R10-R10
Author(s):  
J. F. Hütter ◽  
H. M. Piper ◽  
P. G. Spieckermann
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Substrate Concentration ◽  
Rat Heart ◽  
Acid Oxidation ◽  
Albumin Ratio ◽  
Heart Preparation ◽  
Working Rat Heart

Carnitine effects on palmitate-1-C14 conversion to CO2 and glycerides by various tissues

1964 ◽  
Vol 206 (6) ◽  
pp. 1217-1222 ◽  
Author(s):  
Irving B. Fritz
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Rat Heart ◽  
Liver Microsomes ◽  
Tissue Homogenate ◽  
Acid Oxidation ◽  
Acid Oxidase ◽  
Palmitate Oxidation ◽  
Glyceride Synthesis ◽  
Low Concentrations

Carnitine increased oxidation of palmitate-1-C14 by rat heart and liver preparations, but decreased palmitate incorporation into glycerides. To determine which of the effects was derivative and which was primary, experiments were repeated using tissues whose rates of fatty acid oxidation had been depressed by Amytal poisoning. Under these conditions, carnitine inhibition of fatty acid conversion to glycerides was abolished. Similarly, low concentrations of carnitine were found to enhance palmitate oxidation without influencing palmitate esterification. Isolated liver microsomes which synthesized glycerides without oxidizing fatty acids showed no response to carnitine under all conditions tried. The inability of carnitine to alter glyceride formation in experiments described may signify that acyl-CoA generation from CoA and acylcarnitine is specifically directed toward the fatty acid oxidase system rather than to glyceride synthesis. It was also shown that, under conditions optimal for demonstration of carnitine augmentation of fatty acid oxidation by rat heart preparations, carnitine increased palmitate oxidation by a variety of other tissue homogenate preparations.

scholarly journals EFFECTS OF CORTISOL ON CULTURED RAT HEART CELLS

1973 ◽  
Vol 57 (1) ◽  
pp. 109-116 ◽  
Author(s):  
J. V. Anastasia ◽  
R. L. McCarl
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Free Fatty Acids ◽  
Fatty Acid Oxidation ◽  
Growth Medium ◽  
Rat Heart ◽  
Acid Oxidation ◽  
Heart Cells ◽  
Atp Production ◽  
Rat Heart Cells

This paper reports the determination of the ability of rat heart cells in culture to release [14C]palmitate from its triglyceride and to oxidize this fatty acid and free [14C]palmitate to 14CO2 when the cells are actively beating and when they stop beating after aging in culture. In addition, the levels of glucose, glycogen, and ATP were determined to relate the concentration of these metabolites with beating and with cessation of beating. When young rat heart cells in culture are actively beating, they oxidize free fatty acids at a rate parallel with cellular ATP production. Both fatty acid oxidation and ATP production remain constant while the cells continue to beat. Furthermore, glucose is removed from the growth medium by the cells and stored as glycogen. When cultured cells stop beating, a decrease is seen in their ability to oxidize free fatty acids and to release them from their corresponding triglycerides. Concomitant with decreased fatty acid oxidation is a decrease in cellular levels of ATP until beating ceases. Midway between initiation of cultures and cessation of beating the cells begin to mobilize the stored glycogen. When the growth medium is supplemented with cortisol acetate and given to cultures which have ceased to beat, reinitiation of beating occurs. Furthermore, all decreases previously observed in ATP levels, fatty acid oxidation, and esterase activity are restored.

Effects of rapeseed oil on fatty acid oxidation and lipid levels in rat heart and liver

Lipids ◽  
1976 ◽  
Vol 11 (9) ◽  
pp. 670-675 ◽  
Author(s):  
M. Galli Kienle ◽  
G. Cighetti ◽  
C. Spagnuolo ◽  
C. Galli
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Rat Heart ◽  
Rapeseed Oil ◽  
Acid Oxidation ◽  
Lipid Levels

Fatty acid oxidation capacity and fatty acid-binding protein content of different cell types isolated from rat heart

1990 ◽  
Vol 98 (1-2) ◽  
pp. 19-25 ◽  
Author(s):  
M. C. J. G. Linssen ◽  
M. M. Vork ◽  
Y. F. de Jong ◽  
J. F. C. Glatz ◽  
G. J. van der Vusse
Keyword(s):  
Fatty Acid ◽  
Protein Content ◽  
Fatty Acid Oxidation ◽  
Rat Heart ◽  
Fatty Acid Binding Protein ◽  
Cell Types ◽  
Acid Oxidation ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Different Cell Types

Metabolism of protocatechuic acid influences fatty acid oxidation in rat heart: New anti-angina mechanism implication

2009 ◽  
Vol 77 (6) ◽  
pp. 1096-1104 ◽  
Author(s):  
Yan-guang Cao ◽  
Lin Zhang ◽  
Chen Ma ◽  
Bo-bo Chang ◽  
Yuan-Cheng Chen ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Rat Heart ◽  
Protocatechuic Acid ◽  
Acid Oxidation

In vitro fatty acid oxidation rates in rat heart and liver

Life Sciences ◽  
1973 ◽  
Vol 13 (3) ◽  
pp. 257-267 ◽  
Author(s):  
Melvin M. Mathias ◽  
Jacqueline Dupont ◽  
Dong Ho Hwang
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Rat Heart ◽  
Acid Oxidation ◽  
Oxidation Rates

scholarly journals Decreased long‐chain fatty acid oxidation impairs postischemic recovery of the insulin‐resistant rat heart

2013 ◽  
Vol 27 (10) ◽  
pp. 3966-3978 ◽  
Author(s):  
Romain Harmancey ◽  
Hernan G. Vasquez ◽  
Patrick H. Guthrie ◽  
Heinrich Taegtmeyer
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Rat Heart ◽  
Chain Fatty Acid ◽  
Acid Oxidation ◽  
Long Chain Fatty Acid ◽  
Insulin Resistant ◽  
Postischemic Recovery ◽  
Long Chain
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