Plasma endothelin-1 concentrations are elevated in acute hepatitis and liver cirrhosis but not in chronic hepatitis

1993 ◽  
Vol 28 (5) ◽  
pp. 666-672 ◽  
Author(s):  
Yasushi Uchida ◽  
Makoto Watanabe
Keyword(s):  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Acute Hepatitis ◽  
Endothelin 1

scholarly journals ACUTE HEPATITIS С ON THE BACKGROUND OF LIVER Cirrhosis IN THE OUTCOME OF CHRONIC HEPATITIS C: CLINICAL CASE

2017 ◽  
pp. 118-123
Author(s):  
V. G. Morozov ◽  
E. S. Malova ◽  
L. M. Topornina ◽  
E. V. Jarkova ◽  
A. A. Ribkina ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Acute Hepatitis ◽  
Chronic Hepatitis C ◽  
Clinical Case

Studies of Vitamin B12 Metabolism in Patients with Chronic Hepatitis and Liver Cirrhosis

1968 ◽  
Vol 07 (04) ◽  
pp. 371-387
Author(s):  
T. Spârchez ◽  
B. Gheorghescu ◽  
Gh. Jovin ◽  
Elena Merculiev
Keyword(s):  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Vitamin B12 ◽  
Tracer Technique ◽  
Storage Compartment ◽  
And Storage

SummaryWe have studied the kinetiks of vitamin B12 and especially the liver compartment, in 28 normals and 76 patients with chronic hepatitis and liver cirrhosis.The study was carried out by means of vitamin B12 58Co, administered per os (alone or followed by “flushing dosis”), vitamin B12 57Co administered intravenously and by double tracer technique.Our results indicate the Pertubation of intrahepatic storage compartment of radiocobalamine, in patients with chronic hepatitis and especially in patients with active hepatitis and in cirrhotics.This deficiency can be explained probably, by an alteration of the transport to the liver of the absorbed vitamin B12, by an inadequate chemical forme, by hepatic enzymatic disturbances or by excessive handling and storage in extrahepatic compartment.

Platelet Count Improvement after Chronic Hepatitis C Treatment among Cirrhotic Patients Who Achieved Sustained Virological Response: Realworld Results from 2186 Patients in Egypt

2020 ◽  
Vol 20 ◽  
Author(s):  
Rehab Badawi ◽  
Shaimaa Soliman ◽  
Lobna Aboali ◽  
Mahmoud Elkadeem ◽  
Asem Elfert ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Platelet Count ◽  
Hepatitis C ◽  
Sustained Virological Response ◽  
Virological Response ◽  
Hcv Rna ◽  
End Of Treatment ◽  
Pugh Class ◽  
Direct Acting

Background & Aims: This study aimed to assess the changes in platelet counts of patients with liver cirrhosis due to chronic HCV, who achieved sustained virological response (SVR) after taking direct acting antivirals (DAAs) in a large cohort study in Egypt. Methods: This multicenter observational retrospective study was carried out on 2500 chronic hepatitis C virus (HCV) infected patients who achieved (SVR) after treatment with direct acting antiviral drugs (DAA). HCV infection was confirmed by positive PCR for HCV RNA infection. SVR was defined as a negative PCR test for HCV-RNA 12 weeks after completion of DAA therapy. Platelets count was measured before therapy, during therapy, at the end of treatment, and 12 weeks after the end of the treatment. Results: There were 2186 patients enrolled in the study; 1866 (85.4%) were treatment naïve. There were 1006 (46%) males and 1180 (54%) females. Mean age was 50.82± 11.66 years, 2142 (98 %.0) patients achieved SVR, 2118 (96.9%) patients had Child -Pugh class A cirrhosis, and 68 (3.1%) had Child -Pugh class B liver cirrhosis. A significant increase of the platelets count was detected at the end of treatment in comparison to the pretreatment levels (P<0.001), and after achieving SVR (P <0.001) when compared to the pretreatment values. Conclusion: Improvement of platelets count occurs after HCV therapy with DAAS in patients with liver cirrhosis. These results suggested that HCV eradication may have a role in improvement of platelet count.

Long-lasting Imprint in the Soluble Inflammatory Milieu despite Early Treatment of Acute Symptomatic Hepatitis C

2021 ◽  
Author(s):  
Tanvi Khera ◽  
Yanqin Du ◽  
Daniel Todt ◽  
Katja Deterding ◽  
Benedikt Strunz ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Acute Hepatitis ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection ◽  
Partial Restoration ◽  
Acute Hcv ◽  
Direct Acting ◽  
Inflammatory Milieu

Abstract Background Treatment with direct acting antivirals (DAAs) in patients with chronic hepatitis C infection leads to partial restoration of soluble inflammatory mediators (SIMs). In contrast, we hypothesized that early DAA treatment of acute hepatitis C with DAAs may normalize most SIMs. Methods In this study, we made use of a unique cohort of acute symptomatic hepatitis C who cleared HCV with a 6-week course of ledipasvir/sofosbuvir. Plasma samples were used for proximity extension assay (PEA) measuring 92 proteins. Results Profound SIM alterations were observed in acute HCV patients, with marked upregulation of IL-6 and CXCL10 while certain mediators were down-regulated (e.g. MCP-4, IL-7). During treatment and follow-up, the majority of SIMs decreased but not all normalized (e.g. CDCP1, IL-18). Of note, SIMs that were down-regulated before DAA treatment remained suppressed while others that were initially unchanged, declined to lower values during treatment and follow-up (e.g.CD244). Conclusions Acute hepatitis C was associated with marked changes in the soluble inflammatory milieu as compared to both chronic hepatitis patients and healthy controls. Whereas early DAA treatment partly normalized this altered signature, long-lasting imprints of HCV remained. Thus, acute HCV-induced changes in the immune system may persist even after a short duration of viremia.

scholarly journals Depression in patients with chronic hepatitis B and cirrhosis is closely associated with the severity of liver cirrhosis

2016 ◽  
Vol 12 (1) ◽  
pp. 405-409 ◽  
Author(s):  
HAI-PENG ZHU ◽  
YU-RONG GU ◽  
GENG-LIN ZHANG ◽  
YU-JIE SU ◽  
KE WANG ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B

Serum concentration of E-selectin in patients with chronic hepatitis, liver cirrhosis and hepatocellular carcinoma

2000 ◽  
Vol 126 (6) ◽  
pp. 345-351 ◽  
Author(s):  
Melchiorre Cervello ◽  
Lucrezia Virruso ◽  
Giuseppe Lipani ◽  
Lydia Giannitrapani ◽  
Maurizio Soresi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Serum Concentration

Hepatitis B vaccine

1985 ◽  
Vol 23 (13) ◽  
pp. 49-51
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Liver Cancer ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
World Wide ◽  
Primary Liver Cancer ◽  
Hepatitis B Vaccine ◽  
Common Cause ◽  
B Virus

The hepatitis B virus is the most common cause world-wide of acute hepatitis, and also causes chronic hepatitis, cirrhosis1 and primary liver cancer.2 It can now be prevented by a vaccine. How should this best be used?

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