Mediation by calcium/calmodulin-dependent protein kinase II of suppression of GABAA receptors by NMDA

2000 ◽  
Vol 43 (6) ◽  
pp. 655-662 ◽  
Author(s):  
Dianshi Wang ◽  
Hui Lü ◽  
Tianle Xu
Keyword(s):  
Protein Kinase ◽  
Gabaa Receptors ◽  
Dependent Protein Kinase ◽  
Calcium Calmodulin Dependent ◽  
Protein Kinase Ii ◽  
Dependent Protein

Calcium/Calmodulin-Dependent Protein Kinase II Involvement in Release of Gonadotropin-Releasing Hormone

1998 ◽  
Vol 67 (2) ◽  
pp. 145-152 ◽  
Author(s):  
Wendy W. Waters ◽  
Pat L. Chen ◽  
Newell H. McArthur ◽  
Pete A. Moreno ◽  
Paul G. Harms
Keyword(s):  
Protein Kinase ◽  
Gonadotropin Releasing Hormone ◽  
Dependent Protein Kinase ◽  
Releasing Hormone ◽  
Calcium Calmodulin Dependent ◽  
Protein Kinase Ii ◽  
Dependent Protein

scholarly journals Positive Cooperativity and T286 Autophosphorylation is Observed in a Dimeric Mutant of Calcium-Calmodulin Dependent Protein Kinase II (CaMKII)

2014 ◽  
Vol 106 (2) ◽  
pp. 679a
Author(s):  
Pabak Sarkar ◽  
Kaitlin Davis ◽  
Henry L. Puhl ◽  
Jithesh V. Veetil ◽  
Tuan A. Nguyen ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Dependent Protein Kinase ◽  
Calcium Calmodulin Dependent ◽  
Positive Cooperativity ◽  
Protein Kinase Ii ◽  
Dependent Protein

Calcium/calmodulin-dependent protein kinase II regulates IL-10 production by human T lymphocytes: A distinct target in the calcium dependent pathway

2012 ◽  
Vol 52 (2) ◽  
pp. 51-60 ◽  
Author(s):  
Stavroula Boubali ◽  
Kassiani Liopeta ◽  
Laura Virgilio ◽  
George Thyphronitis ◽  
George Mavrothalassitis ◽  
...  
Keyword(s):  
Protein Kinase ◽  
T Lymphocytes ◽  
Dependent Protein Kinase ◽  
Calcium Dependent ◽  
Human T Lymphocytes ◽  
Calcium Calmodulin Dependent ◽  
Protein Kinase Ii ◽  
Dependent Protein ◽  
Dependent Pathway

scholarly journals Activation State-Dependent Substrate Gating in Ca2+/Calmodulin-Dependent Protein Kinase II

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
D. E. Johnson ◽  
A. Hudmon
Keyword(s):  
Protein Kinase ◽  
Catalytic Domain ◽  
Intrinsic Property ◽  
Dependent Protein Kinase ◽  
Calcium Calmodulin Dependent ◽  
State Dependent ◽  
Protein Kinase Ii ◽  
Dependent Protein ◽  
Substrate Phosphorylation ◽  
The Brain

Calcium/calmodulin-dependent protein kinase II (CaMKII) is highly concentrated in the brain where its activation by the Ca2+sensor CaM, multivalent structure, and complex autoregulatory features make it an ideal translator of Ca2+signals created by different patterns of neuronal activity. We provide direct evidence that graded levels of kinase activity and extent of T287(T286αisoform) autophosphorylation drive changes in catalytic output and substrate selectivity. The catalytic domains of CaMKII phosphorylate purified PSDs much more effectively when tethered together in the holoenzyme versus individual subunits. Using multisubstrate SPOT arrays, high-affinity substrates are preferentially phosphorylated with limited subunit activity per holoenzyme, whereas multiple subunits or maximal subunit activation is required for intermediate- and low-affinity, weak substrates, respectively. Using a monomeric form of CaMKII to control T287autophosphorylation, we demonstrate that increased Ca2+/CaM-dependent activity for all substrates tested, with the extent of weak, low-affinity substrate phosphorylation governed by the extent of T287autophosphorylation. Our data suggest T287autophosphorylation regulates substrate gating, an intrinsic property of the catalytic domain, which is amplified within the multivalent architecture of the CaMKII holoenzyme.

Calcium/calmodulin-dependent protein kinase II supports morphine antinociceptive tolerance by phosphorylation of glycosylated phosducin-like protein

2008 ◽  
Vol 54 (2) ◽  
pp. 319-330 ◽  
Author(s):  
Pilar Sánchez-Blázquez ◽  
María Rodríguez-Muñoz ◽  
Carlos Montero ◽  
Elena de la Torre-Madrid ◽  
Javier Garzón
Keyword(s):  
Protein Kinase ◽  
Dependent Protein Kinase ◽  
Calcium Calmodulin Dependent ◽  
Protein Kinase Ii ◽  
Dependent Protein ◽  
Antinociceptive Tolerance
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