Gastric pH is Increased Similarly by Ranitidine 150mg and 300mg

InPharma ◽  
1987 ◽  
Vol 583 (1) ◽  
pp. 17-17
Keyword(s):  
Gastric Ph ◽  
Ranitidine 150Mg

scholarly journals Amorphous Solid Dispersion Tablets Overcome Acalabrutinib pH Effect in Dogs

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 557
Author(s):  
Deanna M. Mudie ◽  
Aaron M. Stewart ◽  
Jesus A. Rosales ◽  
Nishant Biswas ◽  
Molly S. Adam ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Drug Exposure ◽  
Ph Effect ◽  
Hydroxypropyl Methylcellulose ◽  
Amorphous Solid ◽  
Gastric Ph ◽  
Patient Treatment ◽  
Oral Exposure ◽  
Amorphous Solid Dispersion ◽  
Plasma Drug

Calquence® (crystalline acalabrutinib), a commercially marketed tyrosine kinase inhibitor (TKI), exhibits significantly reduced oral exposure when taken with acid-reducing agents (ARAs) due to the low solubility of the weakly basic drug at elevated gastric pH. These drug–drug interactions (DDIs) negatively impact patient treatment and quality of life due to the strict dosing regimens required. In this study, reduced plasma drug exposure at high gastric pH was overcome using a spray-dried amorphous solid dispersion (ASD) comprising 50% acalabrutinib and 50% hydroxypropyl methylcellulose acetate succinate (HPMCAS, H grade) formulated as an immediate-release (IR) tablet. ASD tablets achieved similar area under the plasma drug concentration–time curve (AUC) at low and high gastric pH and outperformed Calquence capsules 2.4-fold at high gastric pH in beagle dogs. In vitro multicompartment dissolution testing conducted a priori to the in vivo study successfully predicted the improved formulation performance. In addition, ASD tablets were 60% smaller than Calquence capsules and demonstrated good laboratory-scale manufacturability, physical stability, and chemical stability. ASD dosage forms are attractive for improving patient compliance and the efficacy of acalabrutinib and other weakly basic drugs that have pH-dependent absorption.

Effect of gastric pH and of a moderate CYP3A4 inducer on the pharmacokinetics of daridorexant, a dual orexin receptor antagonist

2021 ◽  
Author(s):  
Martine Gehin ◽  
Jolanta Wierdak ◽  
Giancarlo Sabattini ◽  
Patricia N. Sidharta ◽  
Jasper Dingemanse
Keyword(s):  
Receptor Antagonist ◽  
Gastric Ph ◽  
Cyp3a4 Inducer

scholarly journals Gastric Acid-Related Diseases: Focus on Esomeprazole

2010 ◽  
Vol 2 ◽  
pp. CMT.S4500
Author(s):  
B. Al-Judaibi ◽  
N. Chande ◽  
G.K. Dresser ◽  
N. Sultan ◽  
J.C. Gregor
Keyword(s):  
Duodenal Ulcer ◽  
Helicobacter Pylori ◽  
Symptom Relief ◽  
Competitive Inhibitor ◽  
Gastric Ph ◽  
Disease Treatment ◽  
Ulcer Disease ◽  
Zollinger Ellison Syndrome ◽  
Prevention And Treatment ◽  
Inflammatory Drugs

Esomeprazole (S-omeprazole) is a single optical enantiomer proton-pump inhibitor (PPI) approved for the management of gastro-oesophageal reflux disease, the prevention and treatment of Non-Steroidal Anti-Inflammatory Drugs (NSAID) associated gastric ulcer disease, treatment of duodenal ulcer disease associated with Helicobacter pylori infection, and the treatment of Zollinger-Ellison syndrome. Esomeprazole has been shown to be safe and effective during pregnancy and was introduced to the market in 2001. PPI therapy may interact with clopidogrel by cytocrome 2C19. Clopidogrel is a prodrug which is partially activated by cytochrome 2C19 and esomeprazole is a competitive inhibitor of 2C19. Esomeprazole is more effective than other PPIs in controlling esophageal and gastric pH, but efficacy in symptom relief is less clear.

Assessment of Gastric pH in the Critically III

1995 ◽  
Vol E2 (1) ◽  
pp. 50-59
Author(s):  
Kathleen M. Neill ◽  
Helen L. Ahern ◽  
Kathleen T. Rice
Keyword(s):  
Gastric Ph

Preparation and Characterization of a Novel Mixed Functional Cationic Exchange Copolymer Microsphere as Drug Carrier

2012 ◽  
Vol 476-478 ◽  
pp. 2288-2291 ◽  
Author(s):  
Kaewnapa Wongsermsin ◽  
Praneet Opanasopit ◽  
Tanasait Ngawhirunpat ◽  
Prasert Akkaramongkolporn
Keyword(s):  
Drug Carrier ◽  
Gastric Ph ◽  
The Novel ◽  
Electron Micrograph ◽  
Scanning Electron Micrograph ◽  
Cationic Exchange ◽  
The Fourier Transform ◽  
Release Characteristic ◽  
Dextromethorphan Hydrobromide

The objective of the present study was to prepare a novel mixed functional cationic exchange copolymer microsphere containing methyl methacrylic acid and sulfonated styrene crosslinked with divinylbenzene. The emulsion polymerization was used to prepare the cationic exchange copolymer microsphere which was characterized by the scanning electron micrograph (SEM) and the fourier transform infrared spectroscopy (FTIR). The release characteristic of the loaded drug i.e. dextromethorphan hydrobromide from the copolymer microsphere was studied under both simulated gastric (pH 1.2) and intestinal (pH 6.8) conditions. The result showed that the drug released from the novel copolymer microsphere depended on the pH of the release media.

Differences in intragastric pH in diabetic vs. idiopathic gastroparesis: relation to degree of gastric retention

2008 ◽  
Vol 294 (6) ◽  
pp. G1384-G1391 ◽  
Author(s):  
William L. Hasler ◽  
Radoslav Coleski ◽  
William D. Chey ◽  
Kenneth L. Koch ◽  
Richard W. McCallum ◽  
...  
Keyword(s):  
Gastric Acid ◽  
Gastric Ph ◽  
Diabetic Patients ◽  
Gastric Retention ◽  
Gastric Stasis ◽  
Control Subjects ◽  
Idiopathic Gastroparesis ◽  
Initial Ph ◽  
Gastric Scintigraphy ◽  
Ph Profiles

Evidence suggests that distinct mechanisms underlie diabetic and idiopathic gastroparesis. Differences in gastric acid in gastroparesis of different etiologies and varying degrees of gastric stasis are uninvestigated. We tested the hypotheses that 1) gastric pH profiles show differential alteration in diabetic vs. idiopathic gastroparesis and 2) abnormal pH profiles relate to the severity of gastric stasis. Sixty-four healthy control subjects and 44 gastroparesis patients (20 diabetic, 24 idiopathic) swallowed wireless transmitting capsules and then consumed99mTc-sulfur colloid-labeled meals for gastric scintigraphy. Gastric pH from the capsule was recorded every 5 s. Basal pH was higher in diabetic (3.64 ± 0.41) vs. control subjects (1.90 ± 0.18) and idiopathic subjects (2.41 ± 0.42; P < 0.05). Meals evoked initial pH increases that were greater in diabetic (4.98 ± 0.32) than idiopathic patients (3.89 ± 0.39; P = 0.03) but not control subjects (4.48 ± 0.14). pH nadirs prior to gastric capsule evacuation were higher in diabetic patients (1.50 ± 0.23) than control subjects (0.58 ± 0.11; P = 0.003). Four-hour gastric retention was similar in diabetic (18.3 ± 0.5%) and idiopathic (19.4 ± 0.5%) patients but higher than control subjects (2.2 ± 0.5%; P < 0.001). Compared with control subjects, those with moderate-severe stasis (>20% retention at 4 h) had higher basal (3.91 ± 0.55) and nadir pH (2.23 ± 0.42) values ( P < 0.05). In subgroup analyses, both diabetic and idiopathic patients with moderate-severe gastroparesis exhibited increased pH parameters vs. those with mild gastroparesis. In conclusion, diabetic patients with gastroparesis exhibit reduced gastric acid, an effect more pronounced in those with severely delayed gastric emptying. Idiopathic gastroparetic subjects exhibit nearly normal acid profiles, although those with severely delayed emptying show reduced acid vs. those with mild delays. Thus both etiology and degree of gastric stasis determine gastric acidity in gastroparesis.

scholarly journals 24-Hour Measurement of Gastric pH in Rural South Africa

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Alastair M. Sammon ◽  
Eugene J. Ndebia ◽  
Ekambaram Umapathy ◽  
Jehu E. Iputo
Keyword(s):  
South Africa ◽  
Ambulatory Monitoring ◽  
Duodenogastric Reflux ◽  
Lower Oesophageal Sphincter ◽  
Gastric Ph ◽  
Night Time ◽  
High Incidence ◽  
The Mean ◽  
H Pylori ◽  
High Level

Background. Previous studies have established norms of 24-hour gastric pH profiles for western countries. This study was designed to establish the pattern for a rural African population with a high incidence of oesophageal cancer.Methods. After lower oesophageal manometry a probe was placed 10 cm distal to the lower oesophageal sphincter. We carried out 24-hour ambulatory monitoring of gastric pH on 59 healthy subjects. This was satisfactorily completed on 26 female and 18 male (age 21–64, median 35) subjects in the Transkei region of South Africa.Results. The mean 24 hour gastric pH was 2.84 and the mean night-time pH was 3.7. 40 volunteers recorded a night-time pH reaching over 4. 33 volunteers recorded a night-time pH over 7. Night-time alkalinisation was present for 136.4 minutes (25th centile 22.8, 75th centile 208.1) at pH4 or over, and 79.3 (2.5, 122.7) minutes at pH7 or over. Episodes of rapid alkaline rise were 17 (10, 47). 21.1% of these occurred while supine. 35 of 36 tested subjects were positive forH. pyloriIgG.Conclusion. Gastric alkalinisation is common in Transkei, at a higher pH than that reported in other studies, and is sustained longer. Nighttime alkalinisation is frequent. This suggests a high level of duodenogastric reflux.

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