Local and systemic pro-inflammatory and anti-inflammatory cytokine patterns in patients with chronic subdural hematoma: a prospective study

2012 ◽  
Vol 61 (8) ◽  
pp. 845-852 ◽  
Author(s):  
Milo Stanisic ◽  
Ansgar Oddne Aasen ◽  
Are Hugo Pripp ◽  
Karl-Fredrik Lindegaard ◽  
Jon Ramm-Pettersen ◽  
...  
2011 ◽  
Vol 154 (1) ◽  
pp. 113-120 ◽  
Author(s):  
Milo Stanisic ◽  
Staale Petter Lyngstadaas ◽  
Are Hugo Pripp ◽  
Ansgar Oddne Aasen ◽  
Karl-Fredrik Lindegaard ◽  
...  

2018 ◽  
Vol 60 (1) ◽  
pp. 19-23
Author(s):  
Ali K. AL-Shalchy ◽  
Wameedh Q. Abdul-hussein ◽  
Saif S. AL-Musawy

Background: Chronic subdural hematoma is a blood collection in the subdural space for more than 3 weeks from the onset of the bleeding. It is more likely to develop in infancy and after the age of 60 years. The incidence of subdural hematoma is 1- 2 per 100,000 people per year.Objective: To delineate the most common feature aspects of SDH like age, predisposing factors, symptoms and signs and different types of management of the disease.Patients and Methods: A prospective study of 40 patients from the period January 2012 - January 2014, and conducted in Gazi Al-Hariri Hospital of Surgical Specialties, disregarding the age, complaining of chronic subdural hematoma as proved by CT scan. It includes the predisposing factors, the symptoms and signs, the location of hematoma, mode of treatment, complications and the outcome.Results: In this study, the highest incidence of CSDH was above 50 years and the second age group was below 1 year. It was more common in males than females and they were unilateral more than bilateral, as shown by C.T scan which was the most reliable method for diagnosis and assessment.Conclusions: The most suitable treatment was burr hole in the older age group but craniotomy with membranectomy were still performed. In patients below 1 year, subdural peritoneal shunt found to be the method of choice. This study shows that the most common complications are the recurrence and infection. The outcome depends mainly on the early recognition and treatment.Keywords: Chronic subdural hematoma, traumatic brain injury, Burr hole aspiration. ورم دموي تحت الجافية المزمن دراسة مستقبلية  د. علي كامل الشالجي د. وميض قيس عبد الحسين د. سيف سعد الموسوي  الخلاصه: المقدمة: النزف الدموي تحت الام الجافية المزمن هو تجمع الدم في المجال تحت الام الجافية لأكثر من 3 أسابيع من بداية النزف. من المرجح أن تحصل في مرحلة الطفولة وبعد سن 60 عاما. حدوث الورم الدموي تحت الام الجافية هو 1-2 لكل 100,000 شخص سنويا. الهدف من الدراسة: لتعيين المميزات الأكثر شيوعا في النزف الدموي تحت الام القاسية مثل: العمر، والعوامل المؤهلة والأعراض والعلامات وطرق العلاج. مرضى وطرق: دراسة مستقبلية من 40 مريضا من الفترة يناير 2012 - يناير 2014، وأجريت في مستشفى غازي الحريري للتخصصات الجراحية، بغض النظر عن العمر، والذين يشكون من ورم دموي تحت الام الجافية المزمن مشخص بالاشعة المقطعية. وتشمل العوامل المؤهلة، والأعراض والعلامات، وموقع الورم الدموي، وطريقة العلاج، والمضاعفات والنتيجة. النتائج: في هذه الدراسة كانت أعلى نسبة للمرضى الذين تتجاوز اعمارهم أكثر من 50 سنة، وكانت الفئة العمرية الثانية الاكثر شيوعا هي الأقل من 1 سنة. وكان الذكور أكثر شيوعا من الإناث وكانت في جهة واحدة أكثر من الثنائية، كما هو مبين من قبل الاشعة المقطعية التي كان الأسلوب الأكثر موثوقية للتشخيص والتقييم. الاستنتاجات: وكان العلاج الأنسب تثقيب الجمجمة في الفئة العمرية الأكبر سنا ولكن فتح الجمجمة مع استئصال الغشاء لا تزال تنفذ. في المرضى الذين تقل أعمارهم عن 1 سنة، وجدت تحويلة تحت الجافية بريتونية لتكون الطريقة المفضلة. وتبين هذه الدراسة أن المضاعفات الأكثر شيوعا هي التكرار والعدوى. النتيجة تعتمد أساسا على التشخيص المبكر والعلاج. التوصيات: تثقيب الجمجمة يجب ان تكون النهج الجراحي الرئيسي في العلاج للمرضى مع اعطاء علاج الستيرويد لتقليل إمكانية التكرار. مفتاح الكلمات: ورم دموي تحت الام الجافية المزمن، وإصابات الدماغ الصدامية، بزل ثقوب الجمجمة.


2018 ◽  
Vol 13 (2) ◽  
pp. 319 ◽  
Author(s):  
RamKumar Goyal ◽  
Biswaranjan Nayak ◽  
Rajiv Maharshi ◽  
DebadulalDas Bidhar ◽  
Sunil Panchal ◽  
...  

2004 ◽  
Vol 100 (1) ◽  
pp. 24-32 ◽  
Author(s):  
Alessandro Frati ◽  
Maurizio Salvati ◽  
Fabrizio Mainiero ◽  
Flora Ippoliti ◽  
Giovanni Rocchi ◽  
...  

Object. To evaluate the role of local inflammation in the pathogenesis and postoperative recurrence of chronic subdural hematoma (CSDH), the authors conducted an investigation in a selected group of patients who could clearly recall a traumatic event and who did not have other risk factors for CSDH. Inflammation was analyzed by measuring the concentration of the proinflammatory and inflammatory cytokines interleukin (IL)-6 and IL-8. The authors also investigated the possible relationship between high levels of local inflammation that were measured and recurrence of the CSDH. Methods. A prospective study was performed between 1999 and 2001. Thirty-five patients who could clearly recall a traumatic event that had occurred at least 3 weeks previously and who did not have risk factors for CSDH were enrolled. All patients were surgically treated by burr hole irrigation plus external drainage. The concentration of inflammatory cytokines was very high in the lesion, whereas it was normal in serum. In five cases in which recurrence occurred, concentrations of both IL-6 and IL-8 were significantly increased (p < 0.01) in comparison with cases without a recurrence. In a layering hematoma, the IL-6 and IL-8 concentrations were significantly higher (p < 0.05). Layering CSDHs were also significantly correlated with recurrence. Trabecular hematoma had the lowest cytokine levels and the longest median interval between trauma and clinical onset. The interval from trauma did not significantly influence recurrence, although it did differ significantly between the trabecular and layering CSDH groups. Concentrations of IL-6 and IL-8 in the CSDHs did not differ significantly in relation to either the age of the hematoma (measured as the interval from trauma) or the age of the patient. Conclusions. Brain trauma causes the onset of an inflammatory process within the dural border cell layer; high levels of inflammatory cytokines were significantly correlated with recurrence and layering CSDH. A prolonged postoperative antiinflammatory medicine given as prophylaxis may help prevent the recurrence of a CSDH.


The Lancet ◽  
1998 ◽  
Vol 351 (9107) ◽  
pp. 950-953 ◽  
Author(s):  
J VANDISSEL ◽  
P VANLANGEVELDE ◽  
R WESTENDORP ◽  
K KWAPPENBERG ◽  
M FROLICH

Author(s):  
Sergei G. Levin ◽  
Ekaterina V. Pershina ◽  
Nickolay A. Bugaev-Makarovskiy ◽  
Irina Yu. Chernomorets ◽  
Maxim V. Konakov ◽  
...  

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