scholarly journals Novel siRNA delivery strategy: a new “strand” in CNS translational medicine?

2013 ◽  
Vol 71 (1) ◽  
pp. 1-20 ◽  
Author(s):  
Lisa Gherardini ◽  
Giuseppe Bardi ◽  
Mariangela Gennaro ◽  
Tommaso Pizzorusso
2009 ◽  
Vol 138 (2) ◽  
pp. 141-147 ◽  
Author(s):  
Won-Ho Kong ◽  
Dong-Kyung Sung ◽  
Yong-Ho Shim ◽  
Ki Hyun Bae ◽  
Philippe Dubois ◽  
...  

2008 ◽  
Vol 3 (4) ◽  
pp. 371-379 ◽  
Author(s):  
Ewa Lesko ◽  
Katarzyna Miekus ◽  
Agnieszka Grabowska ◽  
Aleksandra Gładys ◽  
Marcin Majka

AbstractSilencing of a target-genes by small interfering RNA (siRNA) has emerged as a powerful new tool not only for basic research but also with potential therapeutic benefits. This paper demonstrates that optimal delivery strategy is crucial for effective target-gene silencing. Using lipofection, under defined conditions, we were able to markedly down-regulate expression of the selected genes involved in rhabdomyosarcoma metastasis: MET, CXCR4, LIFR and PAX3-FKHR.


2013 ◽  
pp. 1-1
Author(s):  
Georgia Bakirtzi ◽  
Giuseppe Battaglia ◽  
Giuseppe Battaglia ◽  
John Price Newell
Keyword(s):  

2011 ◽  
Vol 152 (47) ◽  
pp. 1894-1902
Author(s):  
János Antal ◽  
Attila Timár

Translational medicine is the emerging scientific discipline of the last decade which will set the benchmark for the pharmaceutical industry research and development, integrates inputs from the basic sciences of computer modeling and laboratory research through the pre-clinical and clinical phases of human research to the assimilation of new therapies and treatments into everyday practice of patient care and prevention. With this brief insight authors tried in their humble way to summarize the underlying basis, the present and the potential future of this emerging view, to draw attention to some of the challenges and tasks it faces and to highlight some of the promising approaches, trends and model developments and applications. Orv. Hetil., 2011, 152, 1894–1902.


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