scholarly journals Development of siRNA Delivery Strategy by Active Control of Tumor Microenvironment

2013 ◽  
Vol 133 (3) ◽  
pp. 379-386 ◽  
Author(s):  
Tatsuhiro Ishida ◽  
Hiroshi Kiwada
Keyword(s):  
Tumor Microenvironment ◽  
Active Control ◽  
Sirna Delivery ◽  
Delivery Strategy

Efficient intracellular siRNA delivery strategy through rapid and simple two steps mixing involving noncovalent post-PEGylation

2009 ◽  
Vol 138 (2) ◽  
pp. 141-147 ◽  
Author(s):  
Won-Ho Kong ◽  
Dong-Kyung Sung ◽  
Yong-Ho Shim ◽  
Ki Hyun Bae ◽  
Philippe Dubois ◽  
...  
Keyword(s):  
Sirna Delivery ◽  
Delivery Strategy

scholarly journals Novel siRNA delivery strategy: a new “strand” in CNS translational medicine?

2013 ◽  
Vol 71 (1) ◽  
pp. 1-20 ◽  
Author(s):  
Lisa Gherardini ◽  
Giuseppe Bardi ◽  
Mariangela Gennaro ◽  
Tommaso Pizzorusso
Keyword(s):  
Translational Medicine ◽  
Sirna Delivery ◽  
Delivery Strategy

Optimization of a synthetic siRNA delivery for the treatment of rhabdomyosarcoma

2008 ◽  
Vol 3 (4) ◽  
pp. 371-379 ◽  
Author(s):  
Ewa Lesko ◽  
Katarzyna Miekus ◽  
Agnieszka Grabowska ◽  
Aleksandra Gładys ◽  
Marcin Majka
Keyword(s):  
Gene Silencing ◽  
Small Interfering Rna ◽  
Target Gene ◽  
Target Genes ◽  
Sirna Delivery ◽  
Basic Research ◽  
Delivery Strategy ◽  
Therapeutic Benefits ◽  
Interfering Rna

AbstractSilencing of a target-genes by small interfering RNA (siRNA) has emerged as a powerful new tool not only for basic research but also with potential therapeutic benefits. This paper demonstrates that optimal delivery strategy is crucial for effective target-gene silencing. Using lipofection, under defined conditions, we were able to markedly down-regulate expression of the selected genes involved in rhabdomyosarcoma metastasis: MET, CXCR4, LIFR and PAX3-FKHR.

Albumin-stabilized manganese-based nanocomposites with sensitive tumor microenvironment responsivity and their application for efficient SiRNA delivery in brain tumors

2020 ◽  
Vol 8 (7) ◽  
pp. 1507-1515 ◽  
Author(s):  
Kai Xu ◽  
Zhenghuan Zhao ◽  
Junfeng Zhang ◽  
Wei Xue ◽  
Haipeng Tong ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Brain Tumors ◽  
Sirna Delivery ◽  
Acidic Environments

Synthesis of Mn(iii)/Mn(iv) integrated nanocomposites to realize sensitive MRI performance in weakly acidic environments and efficient siRNA delivery.

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