scholarly journals Neuer Fragebogen zur deutschen Validierung des „Acute Cystitis Symptom Score“

Der Urologe ◽  
2017 ◽  
Vol 56 (3) ◽  
pp. 364-366 ◽  
Author(s):  
J. F. Alidjanov ◽  
A. Pilatz ◽  
U. A. Abdufattaev ◽  
J. Wiltink ◽  
W. Weidner ◽  
...  
Keyword(s):  
Antibiotics ◽  
2018 ◽  
Vol 7 (2) ◽  
pp. 43 ◽  
Author(s):  
Jakhongir Alidjanov ◽  
Kurt Naber ◽  
Ulugbek Abdufattaev ◽  
Adrian Pilatz ◽  
Florian Wagenlehner

2017 ◽  
Vol 142 (24) ◽  
pp. 1814-1819
Author(s):  
Sina Helbig ◽  
Falitsa Mandraka

Was ist neu? Asymptomatische Bakteriurie Laut der neuen Leitlinie soll der Begriff „asymptomatische“ Harnwegsinfektion nicht mehr verwendet werden. Es wird zwischen einer symptomatischen Harnwegsinfektion und der asymptomatischen Bakteriurie unterschieden. Diagnostik Anamnesetools, wie gezielte Fragen zur klinischen Symptomatik oder auch der „acute cystitis symptom score“ (ACSS) können hilfreich sein. Bei typischer Anamnese ist die Durchführung des Urinstatus verzichtbar, da er nicht zur weiteren Erhöhung der Diagnosesicherheit beiträgt. Therapie Harnwegsinfektionen sind ein häufiger Grund für Antibiotikaverschreibungen. Die neue Richtlinie berücksichtigt daher eine kritischere Diagnosestellung und die Notwendigkeit der rationalen Antibiotikatherapie („Antibiotic Stewardship“), u. a. auch die gezieltere Abgrenzung der asymptomatischen Bakteriurie von der symptomatischen Harnwegsinfektion. Neu aufgenommen in die Erstlinienempfehlungen wurde das Antibiotikum Nitroxolin. Das bereits zur Therapie der ersten Wahl empfohlene Pivmecillinam ist nun in Deutschland zugelassen. In die Antibiotikaempfehlungen wurden Gewichtungen hinsichtlich Eradikationsrate, Empfindlichkeit, Kollateralschäden und Sicherheit/Nebenwirkungen aufgenommen mit dem Ziel einer individuelleren Therapiewahl. Die symptomatische Therapie mit Ibuprofen kann nach Abwägung im Arzt-Patientengespräch eine nicht-antibiotische Therapiealternative darstellen. Prophylaxe Der Stellenwert der Immunprophylaxe wurde neu in die Leitlinien aufgenommen und bewertet.


Author(s):  
Konstantinos Stamatiou ◽  
Evangelia Samara ◽  
Jakhongir F. Alidjanov ◽  
Kurt G. Naber ◽  
Adrian Pilatz ◽  
...  

Objective: The Acute Cystitis Symptom Score (ACSS) was developed and validated as a self-reporting questionnaire for diagnosing and monitoring acute, uncomplicated cystitis (AC) in female patients. The study aims at the translation of the ACSS into Greek from original Russian as a source and American English as a new master version and at its linguistic validation. Material and Methods: Three independent professional native Greek translators, two of them experts in Russian and one in English, translated the ACSS from Russian and American English into Greek. The second group of three translators translated each of the three versions back into the original language to detect or correct any important discrepancies. These three Greek versions were then used for linguistic validation. Results: The English to Greek translation reflected more the spoken language, the two Russian to Greek translations more the written, formal language. A total of 60 randomly selected females and 30 healthcare professionals was asked about their preferences and to comment on each of the three translations. Considering all comments the scientific committee (SC) developed the Greek consensus version. For cognitive assessment additional 30 healthcare professionals and 30 females were asked to comment on the intelligibility of all items. Considering their comments the linguistically validated Greek study version was established by the SC. Conclusion: The linguistically validated Greek version of the ACSS can now be used for the clinical validation study.


Antibiotics ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 929
Author(s):  
Jakhongir F. Alidjanov ◽  
Kurt G. Naber ◽  
Adrian Pilatz ◽  
Florian M. Wagenlehner

The diagnosis of acute uncomplicated cystitis (UC) is usually based on clinical symptoms. The study aims to develop and validate the American-English Acute Cystitis Symptom Score (ACSS), a self-reporting questionnaire for diagnosis and patient-reported outcome in women with acute uncomplicated cystitis (UC). After certified translation into American-English and cognitive assessment, the clinical validation of the ACSS was performed embedded in a US phase-II trial. 167 female patients with typical symptoms of UC were included in the study following US Food and Drug Administration (FDA) guidance. At Day 1 (diagnosis), the mean (SD) sum score of the six ACSS typical symptoms reached 10.60 (2.51). Of 100 patients followed-up last time on Day 5 or 6 (End-of-treatment, EoT), 91 patients showed clinical success according to the favored ACSS criteria (sum score of typical symptoms 0.98 (1.94)). There was no correlation between the severity of symptoms on Day 1 or between clinical success rate at EoT and level of bacteriuria on Day 1. The American-English ACSS showed high predictive ability and responsiveness and excellent levels of reliability and validity. It can now be recommended as the new master version in clinical and epidemiological studies, in clinical practice, or for self-diagnosis of women with symptoms of UC.


Antibiotics ◽  
2018 ◽  
Vol 7 (1) ◽  
pp. 6 ◽  
Author(s):  
Jakhongir Alidjanov ◽  
Kurt Naber ◽  
Ulugbek Abdufattaev ◽  
Adrian Pilatz ◽  
Florian Wagenlehner

Antibiotics ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 104 ◽  
Author(s):  
Tommaso Di Vico ◽  
Riccardo Morganti ◽  
Tommaso Cai ◽  
Kurt G. Naber ◽  
Florian M.E. Wagenlehner ◽  
...  

Acute Cystitis Symptom Score (ACSS) is an 18-item self-reporting questionnaire for clinical diagnosis and follow-up of acute uncomplicated cystitis (AUC) in women. The ACSS, originally developed in Uzbek and Russian languages, is now available in several languages. The purpose of the study was to validate the ACSS questionnaire in the Italian language. Linguistic validation was carried out according to Linguistic Validation Manual for Patient-Reported Outcomes Instruments guidelines. Clinical validation was carried out by enrolling one hundred Italian-speaking women. All women were asked to fill in the ACSS questionnaire during their medical visit. Fifty-four women, median age 36 (Inter Quartile Range 28–49), were diagnosed with AUC, while 46 women, median age 38 (IQR 29–45), were enrolled as the control group attending the hospital’s fertility center for couples. The most frequently isolated pathogen in AUC was Escherichia coli (40; 74.0%) followed by Enterococcus faecalis (7; 13.0%) and Staphylococcus saprophyticus (3; 5.6%). Receiver operating characteristic (ROC) curve analysis performed at the first diagnostic visit on a typical symptoms domain cut-off score of 6 revealed a sensitivity of 92.5% and specificity of 97.8%. The Italian version of the ACSS has proved to be a reliable tool with a high accuracy in diagnosis and follow-up in women with AUC. The ACSS may also be useful for clinical and epidemiological studies.


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