Sequence Analysis of the Diabetes-Protective Human Leukocyte Antigen-DQB10602 Allele in Unaffected, Islet Cell Antibody-Positive First Degree Relatives and in Rare Patients with Type 1 Diabetes

1999 ◽  
Vol 84 (5) ◽  
pp. 1722-1728 ◽  
Author(s):  
A. Pugliese
Keyword(s):  
Type 1 Diabetes ◽  
Sequence Analysis ◽  
Human Leukocyte Antigen ◽  
Islet Cell ◽  
Human Leukocyte ◽  
Islet Cell Antibody ◽  
Leukocyte Antigen ◽  
First Degree Relatives ◽  
Cell Antibody

scholarly journals Islet Cell Antibody-Positive Relatives with Human Leukocyte Antigen DQA110102, DQB110602: Identification by the Diabetes Prevention Trial-Type 11

2000 ◽  
Vol 85 (3) ◽  
pp. 1255-1260
Author(s):  
Carla J. Greenbaum ◽  
Desmond A. Schatz ◽  
David Cuthbertson ◽  
Adina Zeidler ◽  
George S. Eisenbarth ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Trial Type ◽  
Diabetes Prevention ◽  
Islet Cell ◽  
Human Leukocyte ◽  
Islet Cell Antibody ◽  
Prevention Trial ◽  
Leukocyte Antigen ◽  
Cell Antibody

scholarly journals Susceptible and Protective Human Leukocyte Antigen Class II Alleles and Haplotypes in Bahraini Type 2 (Non-Insulin-Dependent) Diabetes Mellitus Patients

2005 ◽  
Vol 12 (1) ◽  
pp. 213-217 ◽  
Author(s):  
Ayesha A. Motala ◽  
Marc Busson ◽  
Einas M. Al-Harbi ◽  
Manal A. A. Khuzam ◽  
Emtiaz M. D. Al-Omari ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Class Ii ◽  
Hla Class Ii ◽  
Leukocyte Antigen ◽  
Insulin Dependent

ABSTRACT Whereas the genetic risk for type 1 diabetes is linked to human leukocyte antigen (HLA) class II genes, the HLA association in type 2 (non-insulin-dependent) diabetes is less clear. The association between HLA class II genotypes and type 2 diabetes was examined in adult Bahrainis, an Arab population with a high prevalence of type 2 diabetes. HLA-DRB1* and -DQB1* genotyping of 86 unrelated type 2 diabetes patients (age, 51.6 ± 8.2 years; mean duration of diabetes, 7.7 ± 7.1 years) who had a strong family history of diabetes (52 of 72 versus 0 of 89 for controls, P < 0.001) and 89 healthy subjects was done by PCR-sequence-specific priming. DRB1*040101 (0.1221 versus 0.0562, P = 0.019) and DRB1*070101 (0.2151 versus 0.0843, P < 0.001) were positively associated, while DRB1*110101 (0.0698 versus 0.1461, P = 0.014) and DRB1*160101 (0.0640 versus 0.1236, P = 0.038) were negatively associated with type 2 diabetes. DRB1*040101-DQB1*0302 (0.069 versus 0.0007; P = 0.004), DRB1*070101-DQB1*0201 (0.178 versus 0.0761, P = 0.007), DRB1*070101-DQB1*050101 (0.125 versus 0.0310, P = 0.002), and DRB1*150101-DQB1*060101 (0.0756 versus 0.0281, P = 0.008) were more prevalent among patients, while DRB1*160101-DQB1*050101 (0.0702 versus 0.0349, P = 0.05) was more prevalent among controls, conferring disease susceptibility or protection, respectively. In Bahrainis with type 2 diabetes, there is a significant association with select HLA class II genotypes, which were distinct from those in type 1 diabetes.

scholarly journals Human Leukocyte Antigen (HLA) and Islet Autoantibodies Are Tools to Characterize Type 1 Diabetes in Arab Countries: Emphasis on Kuwait

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Mohamed Jahromi ◽  
Ebaa Al-Ozairi
Keyword(s):  
Type 1 Diabetes ◽  
Human Leukocyte Antigen ◽  
Incidence Rate ◽  
Disease Onset ◽  
Human Leukocyte ◽  
Arab Countries ◽  
World Health ◽  
Leukocyte Antigen ◽  
Prospective Longitudinal

The incidence rate of type 1 diabetes in Kuwait had been increasing exponentially and has doubled in children≤14 years old within almost two decades. Therefore, there is a dire need for a careful systematic familial cohort study. Several immunogenetic factors affect the pathogenesis of the disease. The human leukocyte antigen (HLA) accounts for the major genetic susceptibility to the disease. The triggering agents initiate disease onset by type 1 destruction of pancreatic β-cells. Both HLA and anti-islet antibodies can be used to characterize, predict susceptibility to the disease, innovate, or delay the β-cell destruction. Evidence from prospective longitudinal studies suggested that the underlying disease process represents a continuum that begins before the symptoms are clinically evident. Autoimmunity of the functional pancreatic β-cells results in symptomatic type 1 diabetes and lifelong insulin dependence. The autoantibodies against glutamic acid decarboxylase (GADA), insulinoma antigen-2 (IA-2A), insulin (IAA), and zinc transporter-8 (ZnT-8A) comprise the most reliable biomarkers for type 1 diabetes in both children and adults. Although Kuwait is the second among the top 10 countries with a high incidence rate of type 1 diabetes, there have been no proper diagnostic and prediction tools as per the World Health Organization. The Kuwaiti Type 1 Diabetes Study (KADS) was initiated to understand the disease pathogenesis as well as the HLA and anti-islet autoantibody profile of type 1 diabetes in Kuwait. Understanding the disease sequela in a homogenous gene pool and highly consanguineous population of Kuwaitis could help solve the challenges and pathogenesis, as well as hasten the prevention, of type 1 diabetes.

scholarly journals The Rising Incidence of Type 1 Diabetes Is Accounted for by Cases With Lower-Risk Human Leukocyte Antigen Genotypes

Diabetes Care ◽  
2008 ◽  
Vol 31 (8) ◽  
pp. 1546-1549 ◽  
Author(s):  
S. Fourlanos ◽  
M. D. Varney ◽  
B. D. Tait ◽  
G. Morahan ◽  
M. C. Honeyman ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Human Leukocyte Antigen ◽  
Lower Risk ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Rising Incidence

scholarly journals Aggravation of diabetes, and incompletely deficient insulin secretion in a case with type 1 diabetes-resistant human leukocyte antigen DRB1*15:02 treated with nivolumab

2017 ◽  
Vol 9 (2) ◽  
pp. 438-441 ◽  
Author(s):  
Kimio Matsumura ◽  
Kaoru Nagasawa ◽  
Yoichi Oshima ◽  
Shouta Kikuno ◽  
Kyohei Hayashi ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Secretion ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Leukocyte Antigen
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