scholarly journals Restoration of normal glucose tolerance in severely obese patients after bilio-pancreatic diversion: role of insulin sensitivity and beta cell function

Diabetologia ◽  
2006 ◽  
Vol 49 (9) ◽  
pp. 2136-2143 ◽  
Author(s):  
A. Mari ◽  
M. Manco ◽  
C. Guidone ◽  
G. Nanni ◽  
M. Castagneto ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Normal Glucose Tolerance ◽  
Obese Patients ◽  
Normal Glucose ◽  
Severely Obese

Beta Cell Function, Peripheral Sensitivity to Insulin and Islet Cell Autoimmunity in Cystic Fibrosis Patients with Normal Glucose Tolerance

1990 ◽  
Vol 34 (1) ◽  
pp. 33-38 ◽  
Author(s):  
D. Cucinotta ◽  
Conti Nibali ◽  
T. Arrigo ◽  
A. Di Benedetto ◽  
G. Magazzù ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Glucose Tolerance ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Islet Cell ◽  
Cell Function ◽  
Normal Glucose Tolerance ◽  
Normal Glucose

Association of ghrelin dynamics with beta cell function in Japanese subjects with normal glucose tolerance

2019 ◽  
Vol 91 (5) ◽  
pp. 616-623 ◽  
Author(s):  
Norimitsu Murai ◽  
Naoko Saito ◽  
Eriko Kodama ◽  
Tatsuya Iida ◽  
Kentaro Mikura ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Normal Glucose Tolerance ◽  
Normal Glucose ◽  
Japanese Subjects

scholarly journals Metabolic characteristics of Africans with normal glucose tolerance and elevated 1-hour glucose: insight from the Africans in America study

2020 ◽  
Vol 8 (1) ◽  
pp. e000837 ◽  
Author(s):  
Sara M Briker ◽  
Thomas Hormenu ◽  
Christopher W DuBose ◽  
Lilian S Mabundo ◽  
Stephanie T Chung ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucose Tolerance ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Normal Glucose Tolerance ◽  
Lipid Profiles ◽  
Oral Glucose ◽  
Normal Glucose ◽  
Glucose Threshold

IntroductionRisk of insulin resistance, dyslipidemia, diabetes and cardiac death is increased in Asians and Europeans with normal glucose tolerance (NGT) and 1-hour glucose ≥8.6 mmol/L. As African descent populations often have insulin resistance but a normal lipid profile, the implications for Africans with NGT and glucose ≥8.6 mmol/L (NGT-1-hour-high) are unknown.ObjectiveWe performed oral glucose tolerance tests (OGTTs) in 434 African born-blacks living in Washington, DC (male: 66%, age 38±10 years (mean±SD)) and determined in the NGT group if either glucometabolic or lipid profiles varied according to a 1-hour-glucose threshold of 8.6 mmol/L.MethodsGlucose tolerance category was defined by OGTT criteria. NGT was subdivided into NGT-1-hour-high (glucose ≥8.6 mmol/L) and NGT-1-hour-normal (glucose <8.6 mmol/L). Second OGTT were performed in 27% (119/434) of participants 10±7 days after the first. Matsuda Index and Oral Disposition Index measured insulin resistance and beta-cell function, respectively. Lipid profiles were obtained. Comparisons were by one-way analysis of variance with Bonferonni corrections for multiple comparisons. Duplicate tests were assessed by к-statistic.ResultsOne-hour-glucose ≥8.6 mmol/L occurred in 17% (47/272) with NGT, 72% (97/134) with pre-diabetes and in 96% (27/28) with diabetes. Both insulin resistance and beta-cell function were worse in NGT-1-hour-high than in NGT-1-hour-normal. Dyslipidemia occurred in both the diabetes and pre-diabetes groups but not in either NGT group. One-hour glucose concentration ≥8.6 mmol/L showed substantial agreement for the two OGTTs (к=0.628).ConclusionsAlthough dyslipidemia did not occur in either NGT group, insulin resistance and beta-cell compromise were worse in NGT-1 hour-high. Subdividing the NGT group at a 1-hour glucose threshold of 8.6 mmol/L may stratify risk for diabetes in Africans.

Role of insulin sensitivity and beta cell function in the development of periodontal disease in adults without diabetes

2013 ◽  
Vol 40 (12) ◽  
pp. 1079-1086 ◽  
Author(s):  
Petra Timonen ◽  
Tuomas Saxlin ◽  
Matti Knuuttila ◽  
Anna Liisa Suominen ◽  
Antti Jula ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Periodontal Disease ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function

scholarly journals A Systematic Review of Beta Cell Function in Adults of Black African Ethnicity

2019 ◽  
Vol 2019 ◽  
pp. 1-17 ◽  
Author(s):  
M. Ladwa ◽  
O. Hakim ◽  
S. A. Amiel ◽  
L. M. Goff
Keyword(s):  
Insulin Secretion ◽  
Glucose Tolerance ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Normal Glucose Tolerance ◽  
Qualitative Synthesis ◽  
Intravenous Glucose ◽  
Black African

Background. Understanding ethnic differences in beta cell function has important implications for preventative and therapeutic strategies in populations at high risk of type 2 diabetes (T2D). The existing literature, largely drawn from work in children and adolescents, suggests that beta cell function in black African (BA) populations is upregulated when compared to white Europeans (WE). Methods. A systematic literature search was undertaken in June 2018 to identify comparative studies of beta cell function between adults (>age 18 years) of indigenous/diasporic BA and WE ethnicity. All categories of glucose tolerance and all methodologies of assessing beta cell function in vivo were included. Results. 41 studies were identified for inclusion into a qualitative synthesis. The majority were studies in African American populations (n=30) with normal glucose tolerance (NGT)/nondiabetes (n=25), using intravenous glucose stimulation techniques (n=27). There were fewer studies in populations defined as only impaired fasting glucose/impaired glucose tolerance (IFG/IGT) (n=3) or only T2D (n=3). Although BA broadly exhibited greater peripheral insulin responses than WE, the relatively small number of studies which measured C-peptide to differentiate between beta cell insulin secretion and hepatic insulin extraction (n=14) had highly variable findings. In exclusively IGT or T2D cohorts, beta cell insulin secretion was found to be lower in BA compared to WE. Conclusions. There is inconsistent evidence for upregulated beta cell function in BA adults, and they may in fact exhibit greater deficits in insulin secretory function as glucose intolerance develops.

Increased risk of OGTT-induced hypoglycemia after gastric bypass in severely obese patients with normal glucose tolerance

2015 ◽  
Vol 11 (3) ◽  
pp. 573-577 ◽  
Author(s):  
Marie Pigeyre ◽  
Charlotte Vaurs ◽  
Violeta Raverdy ◽  
Hélène Hanaire ◽  
Patrick Ritz ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Glucose Tolerance ◽  
Normal Glucose Tolerance ◽  
Obese Patients ◽  
Increased Risk ◽  
Normal Glucose ◽  
Severely Obese
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