scholarly journals Heritability of albumin excretion rate in families of patients with Type II diabetes

Diabetologia ◽  
1999 ◽  
Vol 42 (11) ◽  
pp. 1359-1366 ◽  
Author(s):  
C. M. Forsblom ◽  
T. Kanninen ◽  
M. Lehtovirta ◽  
C. Saloranta ◽  
L. C. Groop
Keyword(s):  
Type Ii Diabetes ◽  
Excretion Rate ◽  
Albumin Excretion Rate ◽  
Type Ii ◽  
Albumin Excretion

Glycosaminoglycans as a Possible Tool for Micro- and Macroalbuminuria in Diabetic Patients. A Pilot Study

1997 ◽  
Vol 25 (2) ◽  
pp. 81-86 ◽  
Author(s):  
G Sorrenti ◽  
M Grimaldi ◽  
N Canova ◽  
E Palazzini ◽  
N melchionda
Keyword(s):  
Type Ii Diabetes ◽  
Excretion Rate ◽  
Albumin Excretion Rate ◽  
Favourable Effect ◽  
Diabetic Patients ◽  
Type Ii ◽  
Therapeutic Tool ◽  
Albumin Excretion ◽  
End Of Treatment

The aim was to investigate sulodexide as a possible therapeutic tool for treating micro- and macroalbuminuria in diabetic patients. Fifteen patients (13 micro- and 2 macroalbuminuric) with Type II diabetes, were treated with 600 lipoprotein-lipase releasing units of sulodexide by the intramuscular route, daily for 28 days, and followed up for 2 months. The main evaluation parameter was the albumin excretion rate. At the end of treatment, six of the 13 microalbuminuric patients showed a decrease in the albumin excretion rate, which increased again in three of the six during follow-up. In the two macroalbuminuric patients the albumin excretion rate decreased at the end of treatment and remained unchanged after a further 2 months. Overall analysis (15 patients) showed a significant decrease ( P < 0.05) in the albumin excretion rate compared with baseline. Metabolic control and blood pressure remained unchanged during the entire period of study. No adverse events were registered. It is concluded that sulodexide administration has a favourable effect in reducing the albumin excretion rate in Type II diabetic patients with micro- and macroalbuminuria.

Proteomic analysis for the assessment of diabetic renal damage in humans

2004 ◽  
Vol 107 (5) ◽  
pp. 485-495 ◽  
Author(s):  
Harald MISCHAK ◽  
Thorsten KAISER ◽  
Michael WALDEN ◽  
Meike HILLMANN ◽  
Stefan WITTKE ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Type Ii Diabetes ◽  
Renal Damage ◽  
Excretion Rate ◽  
Albumin Excretion Rate ◽  
Low Grade ◽  
Type Ii ◽  
Polypeptide Pattern ◽  
Albumin Excretion ◽  
Normal Albumin

Renal disease in patients with Type II diabetes is the leading cause of terminal renal failure and a major healthcare problem. Hence early identification of patients prone to develop this complication is important. Diabetic renal damage should be reflected by a change in urinary polypeptide excretion at a very early stage. To analyse these changes, we used an online combination of CE/MS (capillary electrophoresis coupled with MS), allowing fast and accurate evaluation of up to 2000 polypeptides in urine. Employing this technology, we have examined urine samples from 39 healthy individuals and from 112 patients with Type II diabetes mellitus and different degrees of albumin excretion rate. We established a ‘normal’ polypeptide pattern in the urine of healthy subjects. In patients with Type II diabetes and normal albumin excretion rate, the polypeptide pattern in urine differed significantly from normal, indicating a specific ‘diabetic’ pattern of polypeptide excretion. In patients with higher grade albuminuria, we were able to detect a polypeptide pattern indicative of ‘diabetic renal damage’. We also found this pattern in 35% of those patients who had low-grade albuminuria and in 4% of patients with normal albumin excretion. Moreover, we could identify several of the indicative polypeptides using MS/MS sequencing. We conclude that proteomic analysis with CE/MS permits fast and accurate identification and differentiation of polypeptide patterns in urine. Longitudinal studies should explore the potential of this powerful diagnostic tool for early detection of diabetic renal damage.

Angiotensin-converting enzyme (ACE) gene polymorphism in type II diabetic patients with increased albumin excretion rate

1995 ◽  
Vol 9 (4) ◽  
pp. 272-276 ◽  
Author(s):  
Sianna Panagiotopoulos ◽  
Trudy Jeanne Smith ◽  
G.Peter Aldred ◽  
Elizabeth Jane Baker ◽  
Carolyn Jane Jacklin ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Angiotensin Converting Enzyme ◽  
Excretion Rate ◽  
Albumin Excretion Rate ◽  
Diabetic Patients ◽  
Type Ii ◽  
Converting Enzyme ◽  
Albumin Excretion ◽  
Ace Gene ◽  
Ace Gene Polymorphism

Pentoxifylline, albumin excretion rate and proteinuria in type I and type II diabetic patients with microproteinuria. Results of a short-term randomized study

1986 ◽  
Vol 23 (2) ◽  
pp. 171-177 ◽  
Author(s):  
Sebastiano Bruno Solerte ◽  
Marisa Fioravanti ◽  
Anna Bozzetti ◽  
Nicola Schifino ◽  
Anna Linda Patti ◽  
...  
Keyword(s):  
Excretion Rate ◽  
Randomized Study ◽  
Albumin Excretion Rate ◽  
Diabetic Patients ◽  
Type I ◽  
Type Ii ◽  
Short Term ◽  
Albumin Excretion

Correlation between urinary activity of N-acetyl-β-d-glucosaminidase (NAG) and albumin excretion rate in type II (non-insulin-dependent) diabetic subjects

1987 ◽  
Vol 24 (2) ◽  
pp. 149-155 ◽  
Author(s):  
Giuseppa Perdichizzi ◽  
Domenico Cucinotta ◽  
Rosalba Fera ◽  
Enrico Cesare ◽  
Salvatore Campo ◽  
...  
Keyword(s):  
Excretion Rate ◽  
Albumin Excretion Rate ◽  
Type Ii ◽  
Albumin Excretion ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

scholarly journals The expression of POMC and AgRP in brain and kidney tissues at different stages of diabetic nephropathy rats

2021 ◽  
Vol 1 (1) ◽  
pp. 43-49
Author(s):  
Shasha Liu ◽  
Jingjing Da ◽  
Jiayu Li ◽  
Rong Dong ◽  
Jing Yuan ◽  
...  
Keyword(s):  
Body Weight ◽  
Diabetic Nephropathy ◽  
Blood Glucose ◽  
Urinary Albumin Excretion ◽  
Excretion Rate ◽  
Kidney Tissue ◽  
Albumin Excretion Rate ◽  
Urinary Albumin ◽  
Urinary Albumin Excretion Rate ◽  
Albumin Excretion

Abstract Objective To explore the changes of proopiomelanocortin (POMC) and Agouti-Related Peptide (AgRP) expression in brain and kidney tissues under insulin intervention at different stages of diabetic nephropathy (DN) rats. Methods The male Sprague-Dawley (SD) rats of DN were treated with high-fat diet for 8 weeks and induced by intraperitoneally injection of streptozotocin (30 mg/kg) for one time. Then DN rats were also injected insulin subcutaneously at 2–5 U/(kg·24 h) from initiation of the streptozotocin. Kidney tissue, blood sample, and 24 h-urine were collected to detect the ratio of kidney/body weight, blood glucose and 24-h urinary albumin excretion rate at different stages (4, 8, 12, and 16 weeks). Immunohistochemistry assay was used to measure the expression of POMC and AgRP at different stages of DN rats. Results The DN rats were established successfully. With the progression of DN, blood glucose, 24-h urinary albumin excretion rate and kidney body weight ratio increased significantly, while decreased when insulin was injected. Immunohistochemistry showed that the expression levels of POMC were decreased gradually in brain and kidney tissues. Conversely, the expression of AgRP in kidney was highest at week 8 and then decreased gradually. The effect of insulin on normalizing POMC and AgRP expression in brain and renal tissues was also observed in DKD rats. Conclusion With the progression of DN, the expression of POMC and AgRP in kidney tissues was observed at different stages of disease, and their expressions were significantly normalized by insulin. The mechanism of in situ expression of POMC and AGRP in kidney to the progression of DN needs further investigations.

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