Daily symptom associations for urinary urgency and anxiety, depression and stress in women with overactive bladder

2021 ◽  
Author(s):  
Allen A. Mehr ◽  
Karl J. Kreder ◽  
Susan K. Lutgendorf ◽  
Patrick Ten Eyck ◽  
Emma S. Greimann ◽  
...  
Keyword(s):  
Overactive Bladder ◽  
Urinary Urgency ◽  
Anxiety Depression

scholarly journals Muscarinic Receptor Antagonists, the Overactive Bladder and Efficacy against Urinary Urgency

2010 ◽  
Vol 2 ◽  
pp. CMT.S4606 ◽  
Author(s):  
Kylie J. Mansfield
Keyword(s):  
Overactive Bladder ◽  
Muscarinic Receptor ◽  
Cholinergic System ◽  
Urge Urinary Incontinence ◽  
Urinary Urgency ◽  
Receptor Antagonists ◽  
Antimuscarinic Agents ◽  
Bladder Urothelium ◽  
Afferent Nerves ◽  
Muscarinic Receptor Antagonists

The overactive bladder (OAB) is a debilitating condition in which patients suffer from urinary urgency, frequency and nocturia with or without urge urinary incontinence. The mainstay of pharmacotherapy for OAB is muscarinic receptor antagonists, which have been shown to be effective treatments for the symptoms of OAB. The mechanism underlying the efficacy of antimuscarinic agents against the symptoms of OAB is not completely understood. This review explores the role of bladder mucosal muscarinic receptors in the signaling pathways that are activated in response to bladder filling. The cholinergic system is seen to be involved in bladder afferent signaling at many levels and as such muscarinic receptor antagonists may affect bladder signaling via numerous pathways including release of mediators from the bladder urothelium and activation of suburothelial myofibroblasts and afferent nerves. Therefore the mucosal cholinergic system may represent another target for the antimuscarinic agents used to treat OAB.

1963 EFFECT OF ANTIMUSCARINIC TREATMENT IN SUBJECTS WITH OVERACTIVE BLADDER, INCLUDING NOCTURNAL URINARY URGENCY

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Jeffrey Weiss ◽  
Zhanna Jumadilova ◽  
Martin Carlsson ◽  
Mary P. Fitzgerald ◽  
Atul Malhotra ◽  
...  
Keyword(s):  
Overactive Bladder ◽  
Urinary Urgency

scholarly journals The Impact of Urinary Urgency and Frequency on Health-Related Quality of Life in Overactive Bladder: Results from a National Community Survey

2004 ◽  
Vol 7 (4) ◽  
pp. 455-463 ◽  
Author(s):  
Karin S. Coyne ◽  
Chris Payne ◽  
Samir K. Bhattacharyya ◽  
Dennis A. Revicki ◽  
Christine Thompson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Overactive Bladder ◽  
Community Survey ◽  
Urinary Urgency ◽  
Health Related Quality ◽  
National Community ◽  
Related Quality ◽  
Health Related ◽  
The Impact

scholarly journals Comparison of tolterodine and Solifancine in treatment of female with overactive bladder

2021 ◽  
Vol 10 (6) ◽  
pp. 2138
Author(s):  
Nermeen Mohamed Hefila ◽  
Tamer Mamdouh And el dayem ◽  
Hisham Adel Elfazari
Keyword(s):  
Overactive Bladder ◽  
Maternity Hospital ◽  
P Value ◽  
Detrusor Muscle ◽  
Urinary Urgency ◽  
Urinary Frequency ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
Group 1

Background: OAB (overactive bladder) is primarily a neuromuscular problem in which the detrusor muscle contracts inappropriately during bladder filling (i.e., storage phase). These contractions often occur regardless of the amount of urine in the bladder. The aim of this work is to study the effect of Solifenacin in comparison to Tolterodine in treatment of females with idiopathic over active bladder.Methods: This study included 50 patients who presented between March 2020 and February2021 to the outpatients clinic at El-Shatby maternity Hospital, Alexandria university. The patients were complaining of urinary urgency usually with urinary frequency, nocturia with or without urge incontinence. All cases were divided in two groups one of them receive Solifenacin5mg twice daily and the otherreceiveTolterodine2mg twice daily.Results: Both groups showed significant decrease in frequency number per day with p value <0.001ingroup I with Solifenacin which mean statistically significant difference between two groups. When the percentage of symptoms severity were compared between both groups, group 1 showed 53% reduction in symptoms severity while group II showed 6.67% reduction which cleared significant difference statistically in group I (p=0.001). The percentage of reduction of severity of symptoms was compared between the two groups, it showed about 60%reduction in symptoms severity in group 1while in group II only 9.7% reduction. This was statistically significant with (p<0.001) in group I with Solifenacin.Conclusions: This study suggests that Solifenacin10mg/day is more effective than Tolterodine4mg/day in reducing OAB incontinence episodes.

Altered gut microbiome associated with overactive bladder and daily urinary urgency

2020 ◽  
Author(s):  
Teppei Okamoto ◽  
Shingo Hatakeyama ◽  
Atsushi Imai ◽  
Hayato Yamamoto ◽  
Tohru Yoneyama ◽  
...  
Keyword(s):  
Overactive Bladder ◽  
Gut Microbiome ◽  
Urinary Urgency

A VALIDATED PATIENT REPORTED MEASURE OF URINARY URGENCY SEVERITY IN OVERACTIVE BLADDER FOR USE IN CLINICAL TRIALS

2005 ◽  
Vol 174 (2) ◽  
pp. 604-607 ◽  
Author(s):  
ANNABEL NIXON ◽  
SHOSHANA COLMAN ◽  
LUANN SABOUNJIAN ◽  
BOBBY SANDAGE ◽  
UTE E. SCHWIDERSKI ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Overactive Bladder ◽  
Urinary Urgency ◽  
Patient Reported

scholarly journals Efficacy and Safety of Flexible Dose Fesoterodine in Men and Women with Overactive Bladder Symptoms Including Nocturnal Urinary Urgency

2013 ◽  
Vol 189 (4) ◽  
pp. 1396-1401 ◽  
Author(s):  
Jeffrey P. Weiss ◽  
Zhanna Jumadilova ◽  
Theodore M. Johnson ◽  
Mary P. FitzGerald ◽  
Martin Carlsson ◽  
...  
Keyword(s):  
Overactive Bladder ◽  
Urinary Urgency ◽  
Efficacy And Safety ◽  
Men And Women ◽  
Overactive Bladder Symptoms ◽  
Bladder Symptoms ◽  
Flexible Dose

scholarly journals Recent advances in managing overactive bladder

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 1125
Author(s):  
George Araklitis ◽  
Georgina Baines ◽  
Ana Sofia da Silva ◽  
Dudley Robinson ◽  
Linda Cardozo
Keyword(s):  
Urinary Tract Infection ◽  
Botulinum Toxin ◽  
Overactive Bladder ◽  
Overactive Bladder Syndrome ◽  
Urinary Urgency ◽  
Urgency Incontinence ◽  
Effective Treatment Option ◽  
Laser Technology ◽  
Recent Advances ◽  
Genitourinary Syndrome

Overactive bladder syndrome (OAB) is defined as urinary urgency, usually accompanied by frequency and nocturia, with or without urgency incontinence, in the absence of urinary tract infection or other obvious pathology. In this review, we focus on recent advances in the management of OAB. We examine the evidence on the effect of anticholinergic load on OAB patients. Advances in medical treatment include a new beta-3 agonist, vibegron, which is thought to have fewer drug interactions than mirabegron. Treatment of genitourinary syndrome of the menopause with oestrogens and ospemifene have also shown promise for OAB. Botulinum toxin has been shown to be an effective treatment option. We discuss the new implantable neuromodulators that are on the market as well as selective bladder denervation and laser technology.

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