Polymorphisms in the bone morphogenetic protein 2 (BMP2) gene do not affect bone mineral density in white men or women

Influence of bone morphogenetic protein (BMP-2) in its local application in combination with demineralized lyophilized bone implant (DLBI) upon the process of osteogenesis and bone mineral density in the zone of surgical intervention and the whole segment (tibia) was studied in experiment (40 rats). The animals were divided into 2 groups. In animals from the study group the defect zone was filled with both DLBI and BMP-2 while in control group only with DLBI. In evaluation of morphologic changes by points at terms 7 and 12 weeks no reliable differences between the groups were noted. However at 12 weeks in study group cases of marked osteogenesis with full remodeling of bone implant were observed. It was shown that use of BMP-2 in combination with DLBI reliably increased bone mineral density both in the zone of surgical intervention and in the segment as a whole. That fact was regarded as the evidence of BMP-2 positive effect upon the mechanical strength of the forming regenerate.

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Tooth Eruption into the Newly Generated Bone Induced by Recombinant Human Bone Morphogenetic Protein-2

The Cleft Palate-Craniofacial Journal ◽

10.1597/1545-1569_2002_039_0449_teitng_2.0.co_2 ◽

2002 ◽

Vol 39 (4) ◽

pp. 449-456 ◽

Cited By ~ 1

Author(s):

Atsushi Kitamura ◽

Nobuyoshi Motohashi ◽

Tatsuo Kawamoto ◽

Yoshiyuki Baba ◽

Shoichi Suzuki ◽

...

Keyword(s):

Bone Morphogenetic Protein ◽

Alveolar Bone ◽

Treated Group ◽

Tooth Eruption ◽

Human Bone ◽

Bone Morphogenetic Protein 2 ◽

Mineral Density ◽

Morphogenetic Protein ◽

Human Bone Morphogenetic Protein ◽

Recombinant Human Bone

Objective The purpose of this study was to observe tooth eruption pattern into the newly generated bone induced by recombinant human bone morphogenetic protein-2 (rhBMP-2). Method Three 12-week-old beagle dogs were used. Following wound healing of the extracted maxillary third deciduous incisor at the age of 13 weeks, a resection of maxillary alveolar bone (8 mm by 8 mm by 8 mm) was carried out, accompanied by extraction of the maxillary second incisor tooth germ. The rhBMP-2 (5 μg/100 μL or 10 μg/100 μL) was implanted in the resected area. A group that was not implanted after resection and a nonresected group were used as controls. Serial changes of the eruption pattern of the maxillary third incisor in the implanted area were observed radiographically. Oxytetracycline and calcein were employed as bone markers. Nine weeks after the implantation, the animals were sacrificed. The samples were observed histologically and analyzed using peripheral quantitative computerized tomography to acquire the bone mineral density (BMD). Results In the rhBMP-2 (5 μg/100 μL)-treated group, histological findings and the BMD of the newly generated bone were almost same as in the non-resected group. The maxillary third incisor erupted through the implanted area. However, in the rhBMP-2 (10 μg/100 μL)-treated group, more osteoinductive activity and significantly higher BMD were observed in the newly generated bone. The maxillary third incisor erupted mesially so as to avoid this implanted area. Conclusion Results showed that bone remodeling and tooth eruption through the newly generated bone appear to be dose dependent. Accordingly, proper dosage of rhBMP-2 should be determined for successful clinical application.

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Dietary intake of Brazilian black and white men and its relationship to the bone mineral density of the femoral neck

Sao Paulo Medical Journal ◽

10.1590/s1516-31802006000500006 ◽

2006 ◽

Vol 124 (5) ◽

pp. 267-270 ◽

Cited By ~ 9

Author(s):

Patrícia Constante Jaime ◽

Maria do Rosário Dias de Oliveira Latorre ◽

Alex Antonio Florindo ◽

Tomoe Tanaka ◽

Cristiano Augusto de Freitas Zerbini

Keyword(s):

Bone Mineral Density ◽

Femoral Neck ◽

Black Men ◽

Energy Intake ◽

Bone Mineral ◽

White Men ◽

Racial Groups ◽

Mineral Density ◽

Black And White ◽

The Relationship

CONTEXT AND OBJECTIVE: Osteoporosis and fragility fractures are an important public health problem. Although bone loss occurs with age universally, the incidence of bone loss fractures varies greatly between racial groups. The aim of this study was to examine the relationship between calcium, protein and energy intake and the bone mineral density of the femoral neck in Brazilian black and white men. DESIGN AND SETTING: This was a cross-sectional study, carried out in a teaching hospital in São Paulo. METHODS: The participants were 277 volunteer men, aged 50 years or older. The bone mineral density of the femoral neck (FNBMD) was measured by dual energy x-ray absorptiometry. The relationship between FNBMD and calcium, protein and energy intake, as assessed by a three-day food record, was analyzed using multiple linear regression models and was adjusted for age, height, physical activity and education level. The analysis was stratified by race (white and black). RESULTS: FNBMD presented similar means in the two racial groups (p = 0.538). Protein and energy intake did not show a significant correlation with FNBMD, either in the white or in the black population. Calcium intake showed a strong and independent correlation with FNBMD in the black men (partial r = 0.42). CONCLUSION: Calcium intake was a determinant of FNBMD for black men, aged 50 years or older, but not for the white ones.

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Core Ossification of Bone Morphogenetic Protein-2-Loaded Collagenated Bone Mineral in the Sinus

Tissue Engineering Part A ◽

10.1089/ten.tea.2020.0151 ◽

2020 ◽

Author(s):

Jae-Kook Cha ◽

Young Woo Song ◽

Sungtae Kim ◽

Daniel S. Thoma ◽

Ui-Won Jung ◽

...

Keyword(s):

Bone Morphogenetic Protein ◽

Bone Mineral ◽

Bone Morphogenetic Protein 2 ◽

Morphogenetic Protein

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