Comparative high-resolution pQCT analysis of femoral neck indicates different bone mass distribution in osteoporosis and osteoarthritis

2011 ◽  
Vol 23 (7) ◽  
pp. 1967-1975 ◽  
Author(s):  
A. Rubinacci ◽  
D. Tresoldi ◽  
E. Scalco ◽  
I. Villa ◽  
F. Adorni ◽  
...  
Bone Reports ◽  
2021 ◽  
Vol 14 ◽  
pp. 100964
Author(s):  
Ana Cirovic ◽  
Aleksandar Cirovic ◽  
Vladimir Zivkovic ◽  
Slobodan Nikolic ◽  
Petar Milovanovic ◽  
...  

2016 ◽  
Vol 99 (6) ◽  
pp. 588-597 ◽  
Author(s):  
Lukas Kamer ◽  
Hansrudi Noser ◽  
Michael Blauth ◽  
Mark Lenz ◽  
Markus Windolf ◽  
...  

1995 ◽  
Vol 74 (1) ◽  
pp. 125-139 ◽  
Author(s):  
Warren T. K. Lee ◽  
Sophie S. F. Leung ◽  
Doram. Y. Leung ◽  
Heidi S. Y. Tsang ◽  
Joseph Lau ◽  
...  

There is limited information relating Ca intake to bone and height acquisition among Oriental children who consume little or even no milk. The present controlled study investigated the acquisition of bone mass and height of Chinese children with an initial Ca intake of approximately 567 mg/d who were supplemented to about 800 mg/d. Eighty-four 7-year-old Hong Kong Chinese children underwent an 18-month randomized, double-blind, controlled Ca-supplementation trial. The children were randomized to receive either 300 mg elemental Ca or a placebo tablet daily. Bone mass of the distal one-third radius was measured by single-photon absorptiometry, lumbar spine and femoral neck were determined using dual-energy X-ray absorptiometry. Measurements were repeated 6-monthly. Baseline serum 25-hydroxycholecalciferol concentration and physical activity were also assessed. Baseline Ca intakes of the study group and controls were respectively 571 (SD 326) and 563 (SD 337) mg/d. There were no significant differences in baseline serum 25-hydroxycholecalciferol concentration (P= 0·71) and physical activity (P= 0·36) between the study and control groups. After 18 months the study group had significantly greater increases in lumbar-spinal bone mineral content (20·9v. 16. 34%;P= 0·035), lumbar-spinal area (11·16v. 8·71%;P= 0middot;049), and a moderately greater increment in areal bone mineral density of the radius (7·74 0·600%;P= 0.081) when compared with the controls. The results confirm a positive effect of Ca on bone mass of the spine and radius but no effects on femoral-neck and height increase. A longer trial is warranted to confirm a positive Ca effect during childhood that may modify future peak bone mass.


Bone ◽  
1989 ◽  
Vol 10 (2) ◽  
pp. 147-148
Author(s):  
IG Mackie ◽  
ZA Ralis ◽  
RH Leyshon ◽  
J Lane ◽  
G Watkins ◽  
...  

Author(s):  
TP Lam ◽  
G Yang ◽  
H Pang ◽  
BHK Yip ◽  
WYW Lee ◽  
...  

Adolescent idiopathic scoliosis (AIS) is associated with osteopenia which could persist into adulthood affecting attainment of Peak Bone Mass thus resulting in osteoporosis in late adulthood. We previously reported a randomized double-blinded placebo-controlled trial(the Cal study) showing significant bone health improvement with 2-year calcium(Ca)+Vit-D supplementation for AIS girls. This study addressed the important issue whether bone health improvement from the initial 2-year Ca+Vit-D supplementation could persist as subjects approached towards Peak Bone Mass at 6-year ie after 4-year of supplement discontinuation. This was an extension of the Cal study on AIS girls (11–14 years old, mean age=12.9 years, Tanner stage<IV) with femoral neck aBMD Z-score<0 and Cobb angle≥15∘. 330 subjects were randomized to Group1(placebo), Group2(600mgCa+400-IU-Vit-D3/day) or Group3(600mgCa+800-IU-Vit-D3/day) for 2-year supplementation after which supplementation was stopped. Investigations at baseline, 2-year and 6-year included High-resolution Peripheral Quantitative Computed Tomography(HR-pQCT) at distal radius and Dual Energy X-ray Absorptiometry(DXA) at both hips. 270(81.8%) subjects completed 2-year supplementation when changes in left femoral neck aBMD, trabecular vBMD, Trabecular BV/TV, Trabecular Number and Trabecular Separation indicated significant bone health improvement with Ca+Vit-D supplementation(p<0.05). At 6-year(mean age=19.2 years), no between-group difference on bone parameters was noted except increase in Cortical Thickness being greater only in Group3 than in Group1. After 4-year supplement discontinuation, the treatment effect from the initial 2-year supplementation mostly dissipated indicating the need of continued supplementation in AIS girls to sustain therapeutic improvement on bone health as subjects approach towards Peak Bone Mass.


2016 ◽  
Vol 99 (5) ◽  
pp. 443-453 ◽  
Author(s):  
Jesper Fritz ◽  
Rachel L. Duckham ◽  
Timo Rantalainen ◽  
Björn E. Rosengren ◽  
Magnus K. Karlsson ◽  
...  

2013 ◽  
Vol 32 (2) ◽  
pp. 174-183 ◽  
Author(s):  
Graça Cardadeiro ◽  
Fátima Baptista ◽  
Kathleen F. Janz ◽  
Luís A. Rodrigues ◽  
Luís B. Sardinha

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S99-S100
Author(s):  
C.A. Bailey ◽  
S. Kukuljan ◽  
R.M. Daly

Bone ◽  
2018 ◽  
Vol 110 ◽  
pp. 326-334 ◽  
Author(s):  
Andreas Lodberg ◽  
Marco Eijken ◽  
Bram C.J. van der Eerden ◽  
Mette Wendelboe Okkels ◽  
Jesper Skovhus Thomsen ◽  
...  

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