Short period exposure to di-(2-ethylhexyl) phthalate regulates testosterone metabolism in testis of prepubertal rats

2003 ◽  
Vol 77 (8) ◽  
pp. 446-451 ◽  
Author(s):  
Hyung-Sub Kim ◽  
Konomu Saito ◽  
Mayumi Ishizuka ◽  
Akio Kazusaka ◽  
Shoichi Fujita
Keyword(s):  
Testosterone Metabolism ◽  
Short Period ◽  
Prepubertal Rats ◽  
Ethylhexyl Phthalate

scholarly journals Phthalate Esters and Their Potential Risk in PET Bottled Water Stored under Common Conditions

2019 ◽  
Vol 17 (1) ◽  
pp. 141 ◽  
Author(s):  
Xiangqin Xu ◽  
Gang Zhou ◽  
Kun Lei ◽  
Gerald A. LeBlanc ◽  
Lihui An
Keyword(s):  
Storage Time ◽  
Storage Temperature ◽  
Pure Water ◽  
Phthalate Esters ◽  
Storage Condition ◽  
Bottled Water ◽  
Pet Bottles ◽  
Short Period ◽  
Endocrine Disrupting ◽  
Ethylhexyl Phthalate

A great deal of attention has been paid lately to release of phthalate esters (PAEs) from polyethylene terephthalate (PET) bottles into PET bottled drinking water due to their potential endocrine-disrupting effects. Three kinds of PAEs, including diethyl phthalate (DEP), dimethyl phthalate (DMP) and dibutyl phthalate (DBP), were detected in 10 popular brands of PET bottles in Beijing, ranging from 101.97 μg/kg to 709.87 μg/kg. Meanwhile, six kinds of PAEs, including DEP, DMP, DBP, n-butyl benzyl phthalate (BBP), di-n-octyl phthalate (DOP) and di(2-ethylhexyl) phthalate (DEHP), were detected in PET bottled water, ranging from 0.19 μg/L to 0.98 μg/L, under an outdoor storage condition, while their concentrations ranged from 0.18 μg/L to 0.71 μg/L under an indoor storage condition. Furthermore, the concentrations of PAEs in brand D and E bottles were slightly increased when the storage time was prolonged. In addition, the concentrations of PAEs in commercial water contained in brand B and H bottles and pure water contained in brand E and G bottles were also slightly increased with the increase of storage temperature. Interestingly, DBP mainly contributed to the increased PAEs levels in simulation water. These results suggest that a part of the PAEs in PET bottled water originated from plastic bottles, which was related to the storage time and temperature. However, the PAEs in PET bottled water only pose a negligible risk to consumers if they follow the recommendations, such as storage at a common place (24 °C), away from sun and in a short period of time.

Effects of di(2-ethylhexyl) phthalate on gap and tight junction protein expression in the testis of prepubertal rats

2009 ◽  
Vol 72 (11) ◽  
pp. 868-877 ◽  
Author(s):  
Cristian M. Sobarzo ◽  
Livia Lustig ◽  
Roberto Ponzio ◽  
María Olga Suescun ◽  
Berta Denduchis
Keyword(s):  
Protein Expression ◽  
Tight Junction ◽  
Tight Junction Protein ◽  
Tight Junction Protein Expression ◽  
Junction Protein ◽  
Prepubertal Rats ◽  
Ethylhexyl Phthalate

AGE-RELATED CHANGES IN THE METABOLISM OF [3H]TESTOSTERONE IN VITRO BY THE EPIDIDYMIS OF THE IMMATURE RAT

1981 ◽  
Vol 91 (1) ◽  
pp. 43-51 ◽  
Author(s):  
R. G. FOLDESY ◽  
J. H. LEATHEM
Keyword(s):  
Adult Rats ◽  
Testosterone Metabolism ◽  
Pubertal Maturation ◽  
Immature Rat ◽  
Age Related ◽  
Rat Epididymis ◽  
Old Rats ◽  
Prepubertal Rats ◽  
Cauda Epididymidis

We examined the production in vitro of 5α-reduced metabolites from testosterone by the rat epididymis during pubertal maturation. Minced caput and cauda epididymides from 30-, 45-, and 55-day-old rats were incubated with [3H]testosterone for 2 h. Analysis of the radioactive metabolites revealed both similarities and differences in the metabolic patterns compared to those reported for adult rats. As in adults, 5α-dihydrotestosterone was the most abundant metabolite produced by both epididymal segments at all three ages, and it was formed in larger quantities in the caput epididymidis than in the cauda. However, [3H]testosterone metabolism by the epididymis of the immature rat was characterized by a lower formation of 5α-androstane-3α,17β-diol and higher production of 5α-androstane-3,17-dione than in adults. Production of these two metabolites by the caput region increased and decreased respectively, toward adult levels, with increasing age. In addition, the amount of [3H]testosterone metabolized was higher with tissues from prepubertal rats (30 days of age) than with those from rats 55 days of age. These data suggest that testosterone metabolism in the caput begins to change to that of the adult during the period of pubertal maturation but apparently not until later in the cauda epididymidis.

The Origin of the Moon and its Relationship to the Origin of the Solar System

1962 ◽  
Vol 14 ◽  
pp. 133-148 ◽  
Author(s):  
Harold C. Urey
Keyword(s):  
Solar System ◽  
The Moon ◽  
The Past ◽  
The Earth ◽  
Short Period ◽  
Origin Of The Moon

During the last 10 years, the writer has presented evidence indicating that the Moon was captured by the Earth and that the large collisions with its surface occurred within a surprisingly short period of time. These observations have been a continuous preoccupation during the past years and some explanation that seemed physically possible and reasonably probable has been sought.

the effects of resonance with Jupiter in the system of short-period comets

1974 ◽  
Vol 22 ◽  
pp. 193-203
Author(s):  
L̆ubor Kresák
Keyword(s):  
Structural Effects ◽  
Order Resonance ◽  
Mean Motion ◽  
Short Period ◽  
The Mean ◽  
Compound Effect ◽  
Low Order

AbstractStructural effects of the resonance with the mean motion of Jupiter on the system of short-period comets are discussed. The distribution of mean motions, determined from sets of consecutive perihelion passages of all known periodic comets, reveals a number of gaps associated with low-order resonance; most pronounced are those corresponding to the simplest commensurabilities of 5/2, 2/1, 5/3, 3/2, 1/1 and 1/2. The formation of the gaps is explained by a compound effect of five possible types of behaviour of the comets set into an approximate resonance, ranging from quick passages through the gap to temporary librations avoiding closer approaches to Jupiter. In addition to the comets of almost asteroidal appearance, librating with small amplitudes around the lower resonance ratios (Marsden, 1970b), there is an interesting group of faint diffuse comets librating in characteristic periods of about 200 years, with large amplitudes of about±8% in μ and almost±180° in σ, around the 2/1 resonance gap. This transient type of motion appears to be nearly as frequent as a circulating motion with period of revolution of less than one half that of Jupiter. The temporary members of this group are characteristic not only by their appearance but also by rather peculiar discovery conditions.

Models of comets with strongly variable nongravitational effects

1999 ◽  
Vol 173 ◽  
pp. 381-387
Author(s):  
M. Królikowska ◽  
G. Sitarski ◽  
S. Szutowicz
Keyword(s):  
Cometary Nucleus ◽  
Spin Axis ◽  
Reactive Force ◽  
Orbital Elements ◽  
Cometary Nuclei ◽  
Short Period ◽  
Basic Parameters ◽  
Polar Radius ◽  
Cometary Activity ◽  
Nongravitational Effects

AbstractThe nongravitational motion of five “erratic” short-period comets is studied on the basis of published astrometric observations. We present the precession models which successfully link all the observed apparitions of the comets: 21P/Giacobini-Zinner, 31P/Schwassmann-Wachmann 2, 32P/Comas Solá, 37P/Forbes, and 43P/Wolf-Harrington. We used the Sekanina's forced precession model of the rotating cometary nucleus to include the nongravitational terms into equations of the comet's motion. Values of six basic parameters (four connected with the rotating comet nucleus and two describing the precession of spin-axis of the nucleus) have been determined along the orbital elements from positional observations of the comets. The solutions were derived with additional assumptions which introduce instantaneous changes of modulus of reactive force,Aand of maximum of cometary activity with respect to perihelion time. The present precession models impose some contraints on sizes and rotational periods of cometary nuclei. According to our solutions the nucleus of 21P/Giacobini-Zinner with oblateness along the spin-axis of about 0.32 (equatorial to polar radius of 1.46) is the most oblate among five investigated comets.

Covering of cometary nucleus by refractory crust and its evolution into asteroid-like body

1999 ◽  
Vol 173 ◽  
pp. 365-370
Author(s):  
Kh.I. Ibadinov
Keyword(s):  
Laboratory Experiments ◽  
Cometary Nucleus ◽  
Sublimation Rate ◽  
Cometary Nuclei ◽  
Short Period Comet ◽  
Short Period ◽  
Brightness Decrease ◽  
Crust Thickness ◽  
Ice Sublimation ◽  
Period Comet

AbstractFrom the established dependence of the brightness decrease of a short-period comet dependence on the perihelion distance of its orbit it follows that part of the surface of these cometary nuclei gradually covers by a refractory crust. The results of cometary nucleus simulation show that at constant insolation energy the crust thickness is proportional to the square root of the insolation time and the ice sublimation rate is inversely proportional to the crust thickness. From laboratory experiments resulted the thermal regime, the gas productivity of the nucleus, covering of the nucleus by the crust, and the tempo of evolution of a short-period comet into the asteroid-like body studied.

From the Oort cloud to Halley-type comets

1999 ◽  
Vol 173 ◽  
pp. 327-338 ◽  
Author(s):  
J.A. Fernández ◽  
T. Gallardo
Keyword(s):  
Total Population ◽  
Complex Function ◽  
Dynamical Evolution ◽  
Oort Cloud ◽  
Capture Process ◽  
Influx Rate ◽  
Short Period ◽  
Dynamical Properties ◽  
Orbital Periods ◽  
Probability Of Capture

AbstractThe Oort cloud probably is the source of Halley-type (HT) comets and perhaps of some Jupiter-family (JF) comets. The process of capture of Oort cloud comets into HT comets by planetary perturbations and its efficiency are very important problems in comet ary dynamics. A small fraction of comets coming from the Oort cloud − of about 10−2− are found to become HT comets (orbital periods < 200 yr). The steady-state population of HT comets is a complex function of the influx rate of new comets, the probability of capture and their physical lifetimes. From the discovery rate of active HT comets, their total population can be estimated to be of a few hundreds for perihelion distancesq <2 AU. Randomly-oriented LP comets captured into short-period orbits (orbital periods < 20 yr) show dynamical properties that do not match the observed properties of JF comets, in particular the distribution of their orbital inclinations, so Oort cloud comets can be ruled out as a suitable source for most JF comets. The scope of this presentation is to review the capture process of new comets into HT and short-period orbits, including the possibility that some of them may become sungrazers during their dynamical evolution.

Analysis of power law assumptions for short-period comets and Kuiper bodies

1999 ◽  
Vol 173 ◽  
pp. 289-293 ◽  
Author(s):  
J.R. Donnison ◽  
L.I. Pettit
Keyword(s):  
Power Law ◽  
Pareto Distribution ◽  
Limited Data ◽  
Short Period ◽  
Probability Plots ◽  
Exponential Probability

AbstractA Pareto distribution was used to model the magnitude data for short-period comets up to 1988. It was found using exponential probability plots that the brightness did not vary with period and that the cut-off point previously adopted can be supported statistically. Examination of the diameters of Trans-Neptunian bodies showed that a power law does not adequately fit the limited data available.

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