Investigations of putative reproductive toxicity of low-dose exposures to flutamide in Wistar rats

2015 ◽  
Vol 89 (12) ◽  
pp. 2385-2402 ◽  
Author(s):  
Karma C. Fussell ◽  
Steffen Schneider ◽  
Roland Buesen ◽  
Sibylle Groeters ◽  
Volker Strauss ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Low Dose ◽  
Reproductive Toxicity

Investigations of putative reproductive toxicity of low-dose exposures to vinclozolin in Wistar rats

2016 ◽  
Vol 91 (4) ◽  
pp. 1941-1956 ◽  
Author(s):  
Burkhard Flick ◽  
Steffen Schneider ◽  
Stephanie Melching-Kollmuss ◽  
Karma C. Fussell ◽  
Sibylle Gröters ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Low Dose ◽  
Reproductive Toxicity

Reproductive toxicity of low dose nonylphenol in mice: a two-generation study

2017 ◽  
Author(s):  
Sung-Ho Lee ◽  
Yong Bin Kim ◽  
Hee Su Kim
Keyword(s):  
Low Dose ◽  
Reproductive Toxicity

Cocos nucifera L. oil alleviates lead acetate-induced reproductive toxicity in sexually-matured male Wistar rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Olugbemi T. Olaniyan ◽  
Olakunle A. Ojewale ◽  
Ayobami Dare ◽  
Olufemi Adebayo ◽  
Joseph E. Enyojo ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Histological Analysis ◽  
Cocos Nucifera ◽  
Reproductive Toxicity ◽  
Positive Control ◽  
Negative Control ◽  
Male Wistar Rats ◽  
Cocos Nucifera L

Abstract Objectives Lead primarily affects male reproductive functions via hormonal imbalance and morphological damage to the testicular tissue with significant alteration in sperm profile and oxidative markers. Though, different studies have reported that Cocos nucifera L. oil has a wide range of biological effects, this study aimed at investigating the effect of Cocos nucifera L. oil on lead acetate-induced reproductive toxicity in male Wistar rats. Methods Twenty (20) sexually matured male Wistar rats (55–65 days) were randomly distributed into four groups (n=5). Group I (negative control)—distilled water orally for 56 days, Group II (positive control)—5 mg/kg bwt lead acetate intraperitoneally (i.p.) for 14 days, Group III—6.7 mL/kg bwt Cocos nucifera L. oil orally for 56 days and Group IV—lead acetate intraperitoneally (i.p.) for 14 days and Cocos nucifera L. oil for orally for 56 days. Rats were sacrificed by diethyl ether, after which the serum, testis and epididymis were collected and used for semen analysis, biochemical and histological analysis. Results The lead acetate significantly increases (p<0.05) testicular and epididymal malondialdehyde (MDA) levels, while a significant reduction (p<0.05) in sperm parameters, organ weight, testosterone and luteinizing hormone was observed when compared with the negative control. The coadministration of Cocos nucifera oil with lead acetate significantly increases (p<0.05) testosterone, luteinizing hormone, sperm parameters and organ weight, with a significant decrease (p<0.05) in MDA levels compared with positive control. Histological analysis showed that lead acetate distorts testicular cytoarchitecture and germ cell integrity while this was normalized in the cotreated group. Conclusions Cocos nucifera oil attenuates the deleterious effects of lead acetate in male Wistar rats, which could be attributed to its polyphenol content and antioxidant properties.

Biochemical and histopathological effects of low dose vanadium in the healing of acetic acid-induced colitis in male wistar rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Tosan Peter Omayone ◽  
Samuel Babafemi Olaleye
Keyword(s):  
Acetic Acid ◽  
Untreated Control ◽  
Wistar Rats ◽  
Low Dose ◽  
Healing Process ◽  
Beneficial Effects ◽  
Male Wistar Rats ◽  
Haematological Changes ◽  
Therapeutic Properties ◽  
Histopathological Effects

Abstract Objectives Vanadium has been reported to possess relevant therapeutic properties such as anti-diabetic and anti-tumoral. This study aimed at determining the effects of vanadium on experimentally induced colitis in rats. Methods Forty-five male Wistar rats (103 ± 3.90 g, n=15) were used for this study and were divided into three groups. Group 1 (Untreated control) had nothing added to their drinking, while groups 2 and 3 received sodium metavanadate at a dose of 50 and 200 mg/L respectively in their drinking water for 10 weeks. Colitis was thereafter induced by intra colonic administration of 1.50 mL of 6% acetic acid. Animals were sacrificed on day 0 (pre-induction), three- and seven-days post induction. Blood samples were collected for haematological variables and the distal 8 cm of the colon was collected for macroscopic, histological and biochemical (malondialdehyde-MDA, superoxide dismutase-SOD, catalase-CAT, glutathione peroxidase- GPx and nitrite concentration- NO) assessment. Results Low dose vanadium proved beneficial in ameliorating acetic acid-induced colitis by improving both histopathological and haematological changes. Gross observation showed a faster healing rate in vanadium treated groups (50 and 200 mg/L) compared with untreated control at day 3 (40 and 26.20 vs. 2.50%) and day 7 (80 and 66.70 vs. 42%) respectively. Vanadium also appears to exert its beneficial effects on acetic acid-induced colitis via up regulation of antioxidant enzymes (SOD, CAT, GPx) and NO while decreasing the over production of MDA. Conclusions Vanadium at small concentration functions as an essential trace element and may be able to promote healing process during ulcerative colitis.

Characterization of sleep-pattern and neuro-immune-endocrine markers at 24 hour post-injection of a single low dose of lipopolysaccharide in male Wistar rats

2018 ◽  
Vol 320 ◽  
pp. 15-18
Author(s):  
Francisco Nachón-García ◽  
Gabriela Hurtado-Alvarado ◽  
Mario E. Acosta-Hernández ◽  
Carolina Peña-Escudero ◽  
Sergio Priego-Fernández ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Low Dose ◽  
Sleep Pattern ◽  
Post Injection ◽  
Male Wistar Rats

TET1 mediated male reproductive toxicity induced by BPA at low dose through Catsper-Ca2+ signaling pathway

2021 ◽  
pp. 118739
Author(s):  
Wen-bo Yuan ◽  
Hong-qiang Chen ◽  
Jing-zhi Li ◽  
Shi-meng Zhou ◽  
Yong Zeng ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Low Dose ◽  
Reproductive Toxicity

scholarly journals Silica nanoparticles induce unfolded protein reaction mediated apoptosis in spermatocyte cells

2020 ◽  
Vol 9 (4) ◽  
pp. 454-460
Author(s):  
Lihua Ren ◽  
Jianhui Liu ◽  
Jialiu Wei ◽  
Yefan Du ◽  
Kaiyue Zou ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Low Dose ◽  
Caspase 3 ◽  
Reproductive Toxicity ◽  
Chronic Effect ◽  
Unfolded Protein ◽  
Induced Apoptosis ◽  
Protein Response ◽  
Protein Reaction

Abstract With increasing air pollution, silica nanoparticles (SiNPs), as a main inorganic member of PM2.5, have gained increasing attention to its reproductive toxicity. Most existing studies focused on the acute exposure, while data regarding the chronic effect of SiNPs on reproduction is limited. Therefore, this study was designed to evaluate the chronic toxicity of SiNPs on spermatocyte cells. The cells were continuously exposed to SiNPs for 1, 10, 20 and 30 generations at dose of 5 μg/ml SiNPs for 24 h per generation after attachment. The results showed that with the increasing generations of the exposure, SiNPs decreased the viability of spermatocyte cells, induced apoptosis and increased the level of reactive oxygen species in spermatocyte cells. Moreover, SiNPs increased the protein expression of GRP-78, p-PERK, IRE1α, ATF6 and Cleaved caspase-3 in spermatocyte cells, suggesting that SiNPs improved unfolded protein response (UPR) and apoptosis. The present results indicated that the long-term and low-dose exposure to SiNPs could induce apoptosis by triggering ROS-mediated UPR in spermatocyte cells.

Cyclophosphamide-induced reproductive toxicity: Beneficial effects of Helichrysum odoratissimum (Asteraceae) in male Wistar rats

2019 ◽  
Vol 17 (5) ◽  
pp. 366-373 ◽  
Author(s):  
Pierre Watcho ◽  
Ismaelle Rosine Mpeck ◽  
Patrick Brice Deeh Defo ◽  
Modeste Wankeu-Nya ◽  
Esther Ngadjui ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Reproductive Toxicity ◽  
Beneficial Effects ◽  
Male Wistar Rats
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