Reproductive toxicity of low dose nonylphenol in mice: a two-generation study

2017 ◽  
Author(s):  
Sung-Ho Lee ◽  
Yong Bin Kim ◽  
Hee Su Kim
Keyword(s):  
Low Dose ◽  
Reproductive Toxicity

TET1 mediated male reproductive toxicity induced by BPA at low dose through Catsper-Ca2+ signaling pathway

2021 ◽  
pp. 118739
Author(s):  
Wen-bo Yuan ◽  
Hong-qiang Chen ◽  
Jing-zhi Li ◽  
Shi-meng Zhou ◽  
Yong Zeng ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Low Dose ◽  
Reproductive Toxicity

scholarly journals Silica nanoparticles induce unfolded protein reaction mediated apoptosis in spermatocyte cells

2020 ◽  
Vol 9 (4) ◽  
pp. 454-460
Author(s):  
Lihua Ren ◽  
Jianhui Liu ◽  
Jialiu Wei ◽  
Yefan Du ◽  
Kaiyue Zou ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Low Dose ◽  
Caspase 3 ◽  
Reproductive Toxicity ◽  
Chronic Effect ◽  
Unfolded Protein ◽  
Induced Apoptosis ◽  
Protein Response ◽  
Protein Reaction

Abstract With increasing air pollution, silica nanoparticles (SiNPs), as a main inorganic member of PM2.5, have gained increasing attention to its reproductive toxicity. Most existing studies focused on the acute exposure, while data regarding the chronic effect of SiNPs on reproduction is limited. Therefore, this study was designed to evaluate the chronic toxicity of SiNPs on spermatocyte cells. The cells were continuously exposed to SiNPs for 1, 10, 20 and 30 generations at dose of 5 μg/ml SiNPs for 24 h per generation after attachment. The results showed that with the increasing generations of the exposure, SiNPs decreased the viability of spermatocyte cells, induced apoptosis and increased the level of reactive oxygen species in spermatocyte cells. Moreover, SiNPs increased the protein expression of GRP-78, p-PERK, IRE1α, ATF6 and Cleaved caspase-3 in spermatocyte cells, suggesting that SiNPs improved unfolded protein response (UPR) and apoptosis. The present results indicated that the long-term and low-dose exposure to SiNPs could induce apoptosis by triggering ROS-mediated UPR in spermatocyte cells.

Investigations of putative reproductive toxicity of low-dose exposures to flutamide in Wistar rats

2015 ◽  
Vol 89 (12) ◽  
pp. 2385-2402 ◽  
Author(s):  
Karma C. Fussell ◽  
Steffen Schneider ◽  
Roland Buesen ◽  
Sibylle Groeters ◽  
Volker Strauss ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Low Dose ◽  
Reproductive Toxicity

scholarly journals Effects of Oral Domoic Acid Exposure on Maternal Reproduction and Infant Birth Characteristics in a Preclinical Nonhuman Primate Model

2018 ◽  
Author(s):  
Thomas M. Burbacher ◽  
Kimberly S. Grant ◽  
Rebekah Petroff ◽  
Sara Shum ◽  
Brenda Crouthamel ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
High Frequency ◽  
Domoic Acid ◽  
Low Dose ◽  
Reproductive Toxicity ◽  
Physical Characteristics ◽  
Oral Exposure ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Regulatory Guidelines

AbstractDomoic Acid (DA) is a naturally-occurring excitotoxin, produced by marine algae, which can bioaccumulate in shellfish and finfish. The consumption of seafood contaminated with DA is associated with gastrointestinal illness that, in the case of high DA exposure, can evolve into a spectrum of responses ranging from agitation to hallucinations, memory loss, seizures and coma. Because algal blooms that produce DA are becoming more widespread and very little is known about the dangers of chronic, low-dose exposure, we initiated a preclinical study focused on the reproductive and developmental effects of DA in a nonhuman primate model. To this end, 32 adult female Macaca fascicularis monkeys were orally exposed to 0, 0.075 or 0.15 mg/kg/day DA on a daily basis, prior to and during pregnancy. Females were bred to non-exposed males and infants were evaluated at birth. Results from this study provided no evidence of changes in DA plasma concentrations with chronic exposure. DA exposure was not associated with reproductive toxicity or adverse changes in the physical characteristics of newborns. However, in an unanticipated finding, our clinical observations battery revealed the presence of subtle neurological effects in the form of intentional tremors in the exposed adult females. While females in both dose groups displayed increased tremoring, the effect was dose-dependent and observed at a higher frequency in females exposed to 0.15 mg/kg/day. These results demonstrate that chronic, low-level exposure to DA is associated with injury to the adult CNS and suggest that current regulatory guidelines designed to protect human health may not be adequate for high-frequency shellfish consumers.Highlights1) Domoic acid acts as a tremoragen after chronic, low-dose oral exposure in adults.2) Exposure across pregnancy does not result in maternal reproductive toxicity.3) In-utero exposure does not adversely impact physical characteristics of exposed newborns.4) Current regulatory guidelines may not adequately protect high-frequency shellfish consumers from DA-induced neurological injury.

scholarly journals Effects of Vitamin E Supplementation in Male Rats with Crude Oil-Induced Reproductive Toxicity

2017 ◽  
Vol 9 (3) ◽  
pp. 332-337
Author(s):  
Izuchukwu S. OCHIOGU ◽  
Udensi M. IGWEBUIKE ◽  
Edmund C. MBEGBU ◽  
Ikenna O. EZEH ◽  
Paschal F. NNAMANI
Keyword(s):  
Vitamin E ◽  
Crude Oil ◽  
Dose Group ◽  
Low Dose ◽  
Reproductive Toxicity ◽  
Male Rats ◽  
High Dose ◽  
Serum Total Protein ◽  
The Mean ◽  
Vitamin E Supplementation

Crude oil intoxication is a major threat among people and animals living around the crude oil producing regions of the world, hence the search for ameliorating agents. Forty-four male Wistar rats assigned into three groups were used to investigate the effects of vitamin E supplementation on crude oil-induced reprotoxicity (reproductive toxicity) in male rats. Group A represented the unexposed control, whereas groups B and C were exposed orally to 0.15 and 0.3 ml of crude oil respectively every other day for 56 days. Both the low dose and high dose oral administration of crude oil caused a significant reduction in the serum testosterone level (STL) and cauda epididymal sperm reserve (CESR) of the exposed rats when compared to the control. Crude oil withdrawal and vitamin E supplementation significantly improved the cauda epididymal sperm reserve (CESR) in all the subgroups. The serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities of the control and low dose group were significantly lower than those of the high dose group. The high dose crude oil administration significantly decreased the mean serum total protein (STP) and sodium ions (Na+) concentration. The mean serum total cholesterol (STC) value of the low dose group was significantly higher than those of the control and high dose group. However, crude oil withdrawal and vitamin E supplementation did not significantly alter the mean serum total protein (STP) and mean serum total cholesterol (STC) values in all the subgroups. Vitamin E supplementation following low dose crude oil withdrawal enhanced the mean serum Chloride ions (Cl-)concentration. The present findings revealed that Nigerian Qua Iboe Brent crude oil induced serious reprotoxic effects in male rats which vitamin E administration within 28 days did not completely reverse. 

Effects of six priority controlled phthalate esters with long-term low-dose integrated exposure on male reproductive toxicity in rats

2017 ◽  
Vol 101 ◽  
pp. 94-104 ◽  
Author(s):  
Hai-Tao Gao ◽  
Run Xu ◽  
Wei-Xin Cao ◽  
Liang-Liang Qian ◽  
Min Wang ◽  
...  
Keyword(s):  
Low Dose ◽  
Phthalate Esters ◽  
Reproductive Toxicity

RETRACTED ARTICLE: Reproductive toxicity and pathomorphological changes in rats after chronic oral exposure to low-dose depleted uranium

2011 ◽  
Vol 52 (1) ◽  
pp. 169-169
Author(s):  
Yuhui Hao ◽  
Rong Li ◽  
Yanbing Leng ◽  
Jiong Ren ◽  
Jing Liu ◽  
...  
Keyword(s):  
Low Dose ◽  
Reproductive Toxicity ◽  
Depleted Uranium ◽  
Oral Exposure ◽  
Retracted Article

scholarly journals Effects of Atrazine on Reproductive Health of Nondiabetic and Diabetic Male Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Dinesh Babu Jestadi ◽  
Alugoju Phaniendra ◽  
Undru Babji ◽  
Bhavatharini Shanmuganathan ◽  
Latha Periyasamy
Keyword(s):  
Reproductive System ◽  
Low Dose ◽  
Reproductive Toxicity ◽  
Diabetic Rats ◽  
Group Iv ◽  
Male Rats ◽  
Group Iii ◽  
Group I ◽  
Male Wistar Rats ◽  
Nonsignificant Decrease

The aim of the present study was to investigate the effects of low dose of atrazine on reproductive system of male Wistar rats. 16 rats were divided into four groups of four animals each. Group I (nondiabetic) and group III (diabetic) animals served as controls that received safflower oil (300 μL/kg bw/day), respectively. Group II (nondiabetic) and group IV (diabetic) animals received atrazine (300 μg/kg bw/day). Nonsignificant decrease in the activities of antioxidant and steroidogenic enzymes and sperm parameters suggests that atrazine did not produce any effect on reproductive system of rats. Histological findings also revealed that atrazine at a dose of 300 μg/kg bw did not produce any testicular toxic effects in nondiabetic and diabetic atrazine treated rats. Low dose of atrazine did not show reproductive toxicity in rats. To know the effects of atrazine in diabetic rats further studies have to be carried out with increased concentration of atrazine.

Investigations of putative reproductive toxicity of low-dose exposures to vinclozolin in Wistar rats

2016 ◽  
Vol 91 (4) ◽  
pp. 1941-1956 ◽  
Author(s):  
Burkhard Flick ◽  
Steffen Schneider ◽  
Stephanie Melching-Kollmuss ◽  
Karma C. Fussell ◽  
Sibylle Gröters ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Low Dose ◽  
Reproductive Toxicity
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