Short-term antidepressant treatment modulates amygdala response to happy faces

2009 ◽  
Vol 206 (2) ◽  
pp. 197-204 ◽  
Author(s):  
Ray Norbury ◽  
Matthew J. Taylor ◽  
Sudhakar Selvaraj ◽  
Susannah E. Murphy ◽  
Catherine J. Harmer ◽  
...  
Keyword(s):  
Antidepressant Treatment ◽  
Short Term ◽  
Amygdala Response

scholarly journals Short-term antidepressant treatment and facial processing

2007 ◽  
Vol 190 (6) ◽  
pp. 531-532 ◽  
Author(s):  
Ray Norbury ◽  
Clare E. Mackay ◽  
Philip J. Cowen ◽  
Guy M. Goodwin ◽  
Catherine J. Harmer
Keyword(s):  
Emotional Processing ◽  
Antidepressant Treatment ◽  
Placebo Treatment ◽  
Term Treatment ◽  
Short Term ◽  
Short Term Treatment ◽  
Fearful Faces ◽  
Facial Processing ◽  
Amygdala Response ◽  
The Right

SummaryWe used functional magnetic resonance imaging to investigate the effects of short-term treatment with reboxetine, a selective noradrenaline reuptake inhibitor, on emotional facial processing in healthy volunteers. Reboxetine was associated with a reduced amygdala response to fearful faces and increased activation to happy v. neutral facial expressions in the right fusiform gyrus, relative to placebo treatment and in the absence of changes in mood. Our results show that reboxetine modulates the neural substrates of emotional processing, highlighting a mechanism by which drug treatment could normalise negative bias in depression and anxiety.

scholarly journals Clinical importance of long-term antidepressant treatment

2001 ◽  
Vol 179 (S42) ◽  
pp. s4-s8 ◽  
Author(s):  
Robert M. A. Hirschfeld
Keyword(s):  
Antidepressant Treatment ◽  
Clinical Importance ◽  
Maintenance Phase ◽  
Term Treatment ◽  
Antidepressant Therapy ◽  
Short Term ◽  
Short Term Treatment ◽  
Treatment Of Depression ◽  
Patients At Risk

BackgroundDepression, which only a few decades ago was considered to be a short-term illness requiring short-term treatment, is now recognised as a recurrent, sometimes chronic, long-term illness.AimsTo highlight the clinical importance of long-term antidepressant therapy in the treatment of depression.MethodThe current literature was reviewed to examine the relationship between duration of antidepressant therapy and efficacy.ResultsApproximately one-third to a half of patients successfully stabilised in acute-phase treatment will relapse if medication is not sustained throughout the continuation period. Only 10–15% will relapse if medication is continued. For maintenance-phase therapy, approximately 60% of patients at risk will experience a recurrent episode of depression within I year if untreated, whereas those who continue in treatment will have a recurrence rate of between 10% and 30%.ConclusionsRisk of relapse and recurrence of depression can be significantly reduced if adequate continuation and maintenance therapy durations are achieved.

scholarly journals Short-term antidepressant treatment has long-lasting effects, and reverses stress-induced decreases in bone features in rats

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
S. H. Lee ◽  
C. A. Mastronardi ◽  
R. W. Li ◽  
G. Paz-Filho ◽  
E. G. Dutcher ◽  
...  
Keyword(s):  
Antidepressant Treatment ◽  
Short Term

Long-term prospective mood self-rating and antidepressant treatment

2011 ◽  
Vol 28 (4) ◽  
pp. 227-229 ◽  
Author(s):  
Sumana Gadde ◽  
Carl Brown ◽  
Amy Shah ◽  
Rif S. El-Mallakh
Keyword(s):  
Antidepressant Treatment ◽  
Type I ◽  
Short Term ◽  
Delayed Onset ◽  
Antidepressant Use ◽  
Continuous Use ◽  
Medication Changes ◽  
Serotonergic Antidepressant ◽  
Long Term Studies

AbstractThe use of antidepressants in bipolar illness remains controversial. This controversy continues to be fuelled by short-term studies that inconsistently report efficacy or no benefit. However, long-term studies have been consistently unfavourable, suggesting that understanding the long-term course of the illness in the setting of antidepressant treatment is important. This is an extraordinary case in which prospectively collected daily mood ratings were available in a type I bipolar individual who had experienced minimal medication changes over a 21-year period was reviewed. Data regarding the number of euthymic days in the setting of antidepressant use and after antidepressant discontinuation were collected.Induction of cycling and increase in the number of depressed days occurred after five years of continuous serotonergic antidepressant administration. Discontinuation of antidepressants after 11 years of continuous use was associated with only a partial improvement which had a delayed onset. Cycling and increase in depression was noted after years of continuous use of serotonergic antidepressant treatment. Antidepressant-associated destabilisation may occur after long-term exposure and may be associated with prolonged worsening even after antidepressant discontinuation.

Changes occurring in Appetite and Weight during Short-Term Antidepressant Treatment

1984 ◽  
Vol 145 (6) ◽  
pp. 645-648 ◽  
Author(s):  
Brian Harris ◽  
John Young ◽  
Bill Hughes
Keyword(s):  
Clinical Trials ◽  
Weight Change ◽  
Antidepressant Treatment ◽  
Antidepressant Drugs ◽  
Short Term ◽  
Treatment Regimes ◽  
Weight History

SummaryChanges in appetite and weight were recorded in mild to moderately depressed out-patients during the course of clinical trials of various antidepressant drugs. After six weeks, differences due to treatment regimes were minimal. Patients who on becoming depressed experienced severe changes in appetite and weight in either direction, tended to return to normal. The significant associations of appetite and weight change during treatment were with weight, appetite, and carbohydrate preference at presentation, and also with the ‘appetite history’ and ‘weight history’. The associations with the degree of depression were relatively minor.

Short-term antidepressant treatment of comorbid dental anxiety in patients with panic disorder

2005 ◽  
Vol 63 (5) ◽  
pp. 266-271 ◽  
Author(s):  
Sukru Uguz ◽  
Gulsah Seydaoglu ◽  
Cem Doğan ◽  
Banu Yazgan Inanc ◽  
Ebru Yurdagul ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Antidepressant Treatment ◽  
Dental Anxiety ◽  
Short Term
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