Neuroleptic malignant syndrome during low dosed neuroleptic medication in first-episode psychosis: a case report

1999 ◽  
Vol 144 (4) ◽  
pp. 416-418 ◽  
Author(s):  
Friedrich Gönner ◽  
Ralf Baumgartner ◽  
Daniel Schüpbach ◽  
M. C. G. Merlo
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Natalie Martos ◽  
William Hall ◽  
Alicia Marhefka ◽  
Thomas W. Sedlak ◽  
Frederick C. Nucifora

Abstract Background Neutropenia, a decrease in total number of neutrophils below 1500/mm3 and particularly severe neutropenia, defined as neutrophils less than 500/mm3, is a potential adverse effect of antipsychotic medications that can lead to increased risk of infections and death. However, much of the attention on the potential adverse effect is centered exclusively on clozapine, which remains the only antipsychotic medication in the United States requiring standardized monitoring of blood work. We demonstrate here that paliperidone can also cause neutropenia and therefore clinicians should be aware of this possibility especially during initiation of treatment. Case presentation The following report presents the case of a 23-year-old African American male with first episode psychosis who developed neutropenia after initiation of paliperidone. Neutropenia resolved after discontinuation of paliperidone and initiation of an alternative antipsychotic, haloperidol. Conclusions This case report demonstrates an example of paliperidone induced neutropenia which resolved with a switch to haloperidol. We conclude that when initiating paliperidone, clinicians should be more aware of the risk of neutropenia. Moreover, neutropenia may be a more common and overlooked issue in patients on antipsychotic medications other than clozapine and increased awareness of comparative risk across antipsychotics could help direct treatment.


2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Maria Giuseppina Petruzzelli ◽  
Lucia Margari ◽  
Sara Ivagnes ◽  
Roberto Palumbi ◽  
Francesco Margari

2007 ◽  
Vol 13 (2) ◽  
pp. 117-119 ◽  
Author(s):  
HARUN EVCIMEN ◽  
YESNE ALICI-EVCIMEN ◽  
BIJU BASIL ◽  
IRAKLI MANIA ◽  
MAJU MATHEWS ◽  
...  

2018 ◽  
Vol 28 (4) ◽  
pp. 461-463 ◽  
Author(s):  
İbrahim Gundogmus ◽  
Abdulkadir Karagöz ◽  
Ayhan Algül

2022 ◽  
Vol 28 (1) ◽  
pp. 84-88
Author(s):  
Pedro Câmara-Pestana ◽  
Andreia D. Magalhães ◽  
Tiago Mendes ◽  
Pedro Levy ◽  
Ricardo Coentre

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