scholarly journals Selenium methylselenocysteine protects human hepatoma HepG2 cells against oxidative stress induced by tert-butyl hydroperoxide

2007 ◽  
Vol 389 (7-8) ◽  
pp. 2167-2178 ◽  
Author(s):  
Susana Cuello ◽  
Sonia Ramos ◽  
Raquel Mateos ◽  
M. Angeles Martín ◽  
Yolanda Madrid ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hepg2 Cells ◽  
Human Hepatoma ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2

Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide

2006 ◽  
Vol 212 (2) ◽  
pp. 110-118 ◽  
Author(s):  
Mario Alía ◽  
Sonia Ramos ◽  
Raquel Mateos ◽  
Ana Belén Granado-Serrano ◽  
Laura Bravo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Hepatoma ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide ◽  
Hepatoma Hepg2

scholarly journals Meroterpenoid-Rich Fraction of the Ethanolic Extract from Sargassum serratifolium Suppressed Oxidative Stress Induced by Tert-Butyl Hydroperoxide in HepG2 Cells

Marine Drugs ◽  
2018 ◽  
Vol 16 (10) ◽  
pp. 374 ◽  
Author(s):  
Sujin Lim ◽  
Misung Kwon ◽  
Eun-Ji Joung ◽  
Taisun Shin ◽  
Chul-Woong Oh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hepg2 Cells ◽  
Ethanolic Extract ◽  
Glutathione Depletion ◽  
Heme Oxygenase 1 ◽  
Dependent Manner ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide ◽  
Sargassum Serratifolium

Sargassum species have been reported to be a source of phytochemicals, with a wide range of biological activities. In this study, we evaluated the hepatoprotective effect of a meroterpenoid-rich fraction of the ethanolic extract from Sargassum serratifolium (MES) against tert-butyl hydroperoxide (t-BHP)-treated HepG2 cells. Treatment with MES recovered the cell viability from the t-BHP-induced oxidative damage in a dose-dependent manner. It suppressed the reactive oxygen species production, lipid peroxidation, and glutathione depletion in the t-BHP-treated HepG2 cells. The activity of the antioxidants induced by t-BHP, including superoxide dismutase (SOD) and catalase, was reduced by the MES treatment. Moreover, it increased the nuclear translocation of nuclear factor erythroid 2-related factor 2, leading to the enhanced activity of glutathione S transferase, and the increased production of heme oxygenase-1 and NAD(P)H:quinine oxidoreductase 1 in t-BHP-treated HepG2 cells. These results demonstrate that the antioxidant activity of MES substituted the activity of the SOD and catalase, and induced the production of detoxifying enzymes, indicating that MES might be used as a hepatoprotectant against t-BHP-induced oxidative stress.

Cytotoxicity, mutagenicity, oxidative stress and mitochondrial impairment in human hepatoma (HepG2) cells exposed to copper oxide, copper-iron oxide and carbon nanoparticles.

2020 ◽  
Vol 189 ◽  
pp. 109982 ◽  
Author(s):  
Joseph A. Adeyemi ◽  
Ana Rita Thomazela Machado ◽  
Abayomi T. Ogunjimi ◽  
Luciane Carla Alberici ◽  
Lusania Maria Greggi Antunes ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Iron Oxide ◽  
Copper Oxide ◽  
Hepg2 Cells ◽  
Carbon Nanoparticles ◽  
Human Hepatoma ◽  
Mitochondrial Impairment ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2

scholarly journals An aqueous pomegranate seed extract ameliorates oxidative stress of human hepatoma HepG2 cells

2013 ◽  
Vol 94 (8) ◽  
pp. 1622-1627 ◽  
Author(s):  
Marta Navarro ◽  
Miryam Amigo-Benavent ◽  
Marta Mesias ◽  
Gema Baeza ◽  
Vural Gökmen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hepg2 Cells ◽  
Seed Extract ◽  
Human Hepatoma ◽  
Pomegranate Seed ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2

Effect of coffee Melanoidin on human hepatoma HepG2 cells. Protection against oxidative stress induced bytert-butylhydroperoxide

2007 ◽  
Vol 51 (5) ◽  
pp. 536-545 ◽  
Author(s):  
Luis Goya ◽  
Cristina Delgado-Andrade ◽  
José A. Rufián-Henares ◽  
Laura Bravo ◽  
Francisco J. Morales
Keyword(s):  
Oxidative Stress ◽  
Hepg2 Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2

scholarly journals Kushenol C Prevents Tert-Butyl Hydroperoxide and Acetaminophen-Induced Liver Injury

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1635
Author(s):  
Byoung Ok Cho ◽  
Jang Hoon Kim ◽  
Denis Nchang Che ◽  
Hyun Ju Kang ◽  
Jae Young Shin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Hepg2 Cells ◽  
Caspase 3 ◽  
Liver Lipid ◽  
Ros Generation ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Proinflammatory Mediators ◽  
Tert Butyl Hydroperoxide

Sophora flavescens, also known as Kushen, has traditionally been used as a herbal medicine. In the present study we evaluated the ameliorative effects of kushenol C (KC) from S. flavescens against tBHP (tert-Butyl hydroperoxide)-induced oxidative stress in hepatocellular carcinoma (HEPG2) cells and acetaminophen (APAP)-induced hepatotoxicity in mice. KC pretreatment protected the HEPG2 cells against oxidative stress by reducing cell death, apoptosis and reactive oxygen species (ROS) generation. KC pretreatment also upregulated pro-caspase 3 and GSH (glutathione) as well as expression of 8-Oxoguanine DNA Glycosylase (OGG1) in the HEPG2 cells. The mechanism of action was partly related by KC’s activation of Akt (Protein kinase B (PKB)) and Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) in the HepG2 cells. In in vivo investigations, coadministration of mice with KC and APAP significantly attenuated APAP-induced hepatotoxicity and liver damage, as the serum enzymatic activity of aspartate aminotransferase and alanine aminotransferase, as well as liver lipid peroxidation and cleaved caspase 3 expression, were reduced in APAP-treated mice. Coadministration with KC also up-regulated antioxidant enzyme expression and prevented the production of proinflammatory mediators in APAP-treated mice. Taken together, these results showed that KC treatment has potential as a therapeutic agent against liver injury through the suppression of oxidative stress.

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