Evaluation and Development of Automatic Two-Dimensional Measurements of Histomorphometric Parameters Reflecting Trabecular Bone Connectivity: Correlations with Dual-Energy X-Ray Absorptiometry and Quantitative Ultrasound in Human Calcaneum

2005 ◽  
Vol 77 (4) ◽  
pp. 195-204 ◽  
Author(s):  
Nathalie R. Portero ◽  
Monique E. Arlot ◽  
Jean-Paul Roux ◽  
François Duboeuf ◽  
Pascale M. Chavassieux ◽  
...  
2021 ◽  
Author(s):  
Deok Hyun (Danny) Jang

Dual-energy X-ray absorptiometry (DXA) is the gold standard of bone densitometry. However, inaccurate estimation of areal bone mineral density (aBMD) is of concern when calcium in bone mineral is partially substituted with bone-seeking elements such as strontium, lead and aluminum. Quantitative ultrasound (QUS) is an alternative bone densitometry technique that can assess bone health based on the measurement of acoustic parameters. This study aims to investigate the effect of the clinically relevant concentrations of bone-seeking elements on aBMD measured by DXA and the acoustic parameters measured by QUS, using trabecular bone-mimicking phantoms. Statistically significant linear relationship was observed between aBMD and strontium concentration. For clinically relevant concentrations of lead and aluminum, the deviation in aBMD measurements was within 1% coefficient of variation of DXA. No statistically significant deviation was observed in stiffness index measurement by QUS in the presence of any of the three bone-seeking elements


2021 ◽  
Author(s):  
Deok Hyun (Danny) Jang

Dual-energy X-ray absorptiometry (DXA) is the gold standard of bone densitometry. However, inaccurate estimation of areal bone mineral density (aBMD) is of concern when calcium in bone mineral is partially substituted with bone-seeking elements such as strontium, lead and aluminum. Quantitative ultrasound (QUS) is an alternative bone densitometry technique that can assess bone health based on the measurement of acoustic parameters. This study aims to investigate the effect of the clinically relevant concentrations of bone-seeking elements on aBMD measured by DXA and the acoustic parameters measured by QUS, using trabecular bone-mimicking phantoms. Statistically significant linear relationship was observed between aBMD and strontium concentration. For clinically relevant concentrations of lead and aluminum, the deviation in aBMD measurements was within 1% coefficient of variation of DXA. No statistically significant deviation was observed in stiffness index measurement by QUS in the presence of any of the three bone-seeking elements


2012 ◽  
Vol 23 (7) ◽  
pp. 1947-1956 ◽  
Author(s):  
J. Rawal ◽  
K. Eleftheriou ◽  
J. Skipworth ◽  
Z. Puthucheary ◽  
M. Loosemore ◽  
...  

2018 ◽  
Vol 30 (4) ◽  
pp. 466-473 ◽  
Author(s):  
Ana Torres-Costoso ◽  
Dimitris Vlachopoulos ◽  
Esther Ubago-Guisado ◽  
Asunción Ferri-Morales ◽  
Iván Cavero-Redondo ◽  
...  

Purpose: The present study aims to investigate the association between dual-energy X-ray absorptiometry (DXA) and quantitative ultrasound (QUS) parameters and the intermethods agreement in active males. Methods: In this cross-sectional study, bone health (by DXA and calcaneal QUS), physical activity (by accelerometers), and anthropometrics measurements were assessed in 117 active adolescents (12–14 y old). Bivariate correlation coefficients were calculated to assess the relationships between DXA standard regions of interest and QUS parameters. Intraclass correlation coefficients and Bland–Altman plots were used to assess the level of agreement between bone mineral content regions derived from DXA and stiffness index. The measurements were z score transformed for comparison. Results: Most QUS parameters were positive and significantly correlated with DXA outcomes (stiffness index: r = .43–.52; broadband ultrasound attenuation: r = .50–.58; speed of sound: r = .25–.27) with the hip showing the highest correlations. Moreover, the present study found fair to good intraclass correlation coefficients of agreement (.60–.68) between DXA and QUS to assess bone health. The Bland–Altman analysis showed a limited percentage of outliers (3.2%–8.6%). Conclusion: QUS device could represent an acceptable alternative method to assess bone health in active adolescent males.


2019 ◽  
Vol 22 (4) ◽  
pp. 501-505 ◽  
Author(s):  
Kelly Krohn ◽  
Elliott N. Schwartz ◽  
Yoon-Sok Chung ◽  
E. Michael Lewiecki

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