Single ascending oral dose pharmacokinetics and pharmacodynamics study of EV-077: the specific inhibitor of prostanoid- and isoprostane-induced cellular activation

2012 ◽  
Vol 69 (3) ◽  
pp. 459-465 ◽  
Author(s):  
A. Richardson ◽  
K. S. Sakariassen ◽  
J.-P. Meyer ◽  
P. Alberts ◽  
A. S. Sorensen
Keyword(s):  
Oral Dose ◽  
Specific Inhibitor ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Cellular Activation

Pharmacokinetics and Pharmacodynamics of Amoxicillin-Sulbactam, a Novel Aminopenicillin–β-Lactamase Inhibitor Combination, against Escherichia coli

1999 ◽  
Vol 43 (6) ◽  
pp. 1503-1504 ◽  
Author(s):  
Carlos Bantar ◽  
Federico Nicola ◽  
Hector J. Arenoso ◽  
Marcelo Galas ◽  
Liliana Soria ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Drug Combination ◽  
Pharmacokinetics And Pharmacodynamics ◽  
E Coli ◽  
Inhibitory Activities ◽  
Novel Drug ◽  
Inhibitor Combination ◽  
Lactamase Inhibitor

ABSTRACT We evaluated the pharmacokinetics of amoxicillin-sulbactam (AMX-SUL), a novel drug combination, and its pharmacodynamics againstEscherichia coli in 12 volunteers receiving a single oral dose (1,000 mg). Peak serum bactericidal and urine inhibitory activities in most volunteers were observed against E. colistrains for which AMX-SUL MICs were low (2- to 4-mg/liter) (2 strains) and high (≥16-mg/liter) (47 strains), respectively.

scholarly journals Pharmacokinetics and Pharmacodynamics of Levofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in Human Skin Blister Fluid

2000 ◽  
Vol 44 (5) ◽  
pp. 1352-1355 ◽  
Author(s):  
Andrej Trampuz ◽  
Markus Wenk ◽  
Zarko Rajacic ◽  
Werner Zimmerli
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
Oral Dose ◽  
Human Skin ◽  
Bactericidal Activity ◽  
Ex Vivo ◽  
Blister Fluid ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Skin Blister ◽  
And Staphylococcus Aureus

ABSTRACT The pharmacokinetics of levofloxacin in serum and in skin blister fluid (SBF) was determined for 20 volunteers after a single 500-mg oral dose of levofloxacin. In addition, ex vivo bactericidal activity of SBF against Streptococcus pneumoniae and Staphylococcus aureus was studied. SBF containing levofloxacin and granulocytes killed 5.2 log of Streptococcus pneumoniae bacteria and 2.0 log of Staphylococcus aureus bacteria during a 6-h incubation.

The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASP3652 in First-in-Human and Ascending Multiple Oral Dose Studies in Healthy Subjects

2020 ◽  
Vol 37 (9) ◽  
pp. 3878-3900
Author(s):  
Masaomi Takizawa ◽  
Dirk Cerneus ◽  
Ingrid Michon ◽  
Sanne Rijnders ◽  
Desiree van der Heide ◽  
...  
Keyword(s):  
Oral Dose ◽  
Healthy Subjects ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Multiple Oral Dose

Effect of itraconazole on the single oral dose pharmacokinetics and pharmacodynamics of alprazolam

1998 ◽  
Vol 139 (3) ◽  
pp. 269-273 ◽  
Author(s):  
Norio Yasui ◽  
T. Kondo ◽  
Koichi Otani ◽  
Hanako Furukori ◽  
Sunao Kaneko ◽  
...  
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Pharmacokinetics And Pharmacodynamics

A Single Preoperative Oral Dose of Valdecoxib, a New Cyclooxygenase-2 Specific Inhibitor, Relieves Post-Oral Surgery or Bunionectomy Pain

2002 ◽  
Vol 97 (3) ◽  
pp. 565-573 ◽  
Author(s):  
Paul J. Desjardins ◽  
Vincent S. Shu ◽  
David P. Recker ◽  
Kenneth M. Verburg ◽  
Clifford J. Woolf
Keyword(s):  
Adverse Events ◽  
Oral Dose ◽  
Pain Intensity ◽  
Rescue Medication ◽  
Oral Surgery ◽  
Specific Inhibitor ◽  
Analgesic Efficacy ◽  
The United States ◽  
Cyclooxygenase 2 ◽  
Global Evaluation

Background The trend toward day-case surgery, with discharge on oral medication, has highlighted the need for effective and safe analgesics that facilitate a rapid recovery and discharge time. This study evaluated the analgesic efficacy, dose dependency, duration of action, and safety of the cyclooxygenase-2 specific inhibitor, valdecoxib, administered before oral or orthopedic surgery. Methods Eligible healthy adult patients were scheduled to undergo either extraction of two impacted third molar teeth (n = 284) or bunionectomy surgery (n = 223) with local anesthesia in two randomized, double-blind, placebo-controlled studies conducted at three centers in the United States. Patients received a single, preoperatively administered oral dose of placebo or 10 (oral surgery only), 20, 40, or 80 mg valdecoxib. Analgesic efficacy was assessed postoperatively, over a 24-h treatment period, or until the patient required rescue medication. Efficacy measures included time to rescue medication, proportion of patients requiring such rescue, pain intensity, and the Patient's Global Evaluation of Study Medication. Results In both studies, all doses of valdecoxib produced analgesia with a duration (time to rescue analgesia) and magnitude (Pain Intensity, Patient's Global Evaluation) significantly greater than placebo. A dose-dependent effect was observed up to 40 mg valdecoxib, with an 80-mg dose providing no additional analgesic benefit. In both models, all doses of valdecoxib were well tolerated, with no clinically significant treatment-related gastrointestinal, renal, or platelet-derived adverse events, and no evidence of a dose-related increase in adverse events. Conclusions Preoperative orally administered valdecoxib provides well-tolerated and effective analgesia for mild to moderate postoperative pain.

scholarly journals Safety, tolerability, pharmacokinetics and pharmacodynamics of losmapimod following a single intravenous or oral dose in healthy volunteers

2013 ◽  
Vol 76 (1) ◽  
pp. 99-106 ◽  
Author(s):  
April M. Barbour ◽  
Lea Sarov-Blat ◽  
Gengqian Cai ◽  
Michael J. Fossler ◽  
Dennis L. Sprecher ◽  
...  
Keyword(s):  
Oral Dose ◽  
Healthy Volunteers ◽  
Pharmacokinetics And Pharmacodynamics

No Effect of Itraconazole on the Single Oral Dose Pharmacokinetics and Pharmacodynamics of Estazolam

2002 ◽  
Vol 24 (3) ◽  
pp. 375-378 ◽  
Author(s):  
Yohei Otsuji ◽  
Naoyuki Okuyama ◽  
Toshiaki Aoshima ◽  
Takashi Fukasawa ◽  
Kimiyasu Kato ◽  
...  
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Pharmacokinetics And Pharmacodynamics

The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites in healthy adults after a single oral dose

1989 ◽  
Vol 46 (4) ◽  
pp. 408-419 ◽  
Author(s):  
Rebecca A Boyd ◽  
Shu K Chin ◽  
Oluta Don-Pedro ◽  
Davide Verotta ◽  
Lewis B Sheiner ◽  
...  
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Healthy Adults ◽  
Pharmacokinetics And Pharmacodynamics
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