Scientific quality of clinical research an analysis of 40 research projects in pharmacology/pharmacotherapy

Scientific research is part of any university mission, at least of big universities, as it represents the complementary element required by the learning process. A learning process based on engendering knowledge is much more valuable and competitive than a learning process which is reduced to a mere transfer of knowledge from the teacher to the students. The important universities consider that “the development of scientific research as a fundamental competence is essential for survival in a more and more competitive environment on global level and that is why, research should be part of the university mission”1. This study aims to highlight how important it is for the university members to be aware of the evaluation criteria for the research projects they undertake. For this purpose, I have interviewed a number of 55 persons, project managers and team members in the projects from the “Research for Excellency” program and the National Plan of Research, Development and Innovation PN II 2007 – 2013. Out of the evaluation criteria for research, the most important ones were considered to be the scientific quality of the project and the quality of the human resources involved in the project.

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Quality of life assessment in laryngectomized individuals: do we need additions to standard questionnaires in specific clinical research projects?

Clinical Otolaryngology ◽

10.1111/j.1365-2273.2004.00932.x ◽

2005 ◽

Vol 30 (2) ◽

pp. 169-175 ◽

Cited By ~ 39

Author(s):

B.M.R. Op de Coul ◽

A.H. Ackerstaff ◽

C.J. Van As ◽

F.J.A. Van Den Hoogen ◽

C.A. Meeuwis ◽

...

Keyword(s):

Quality Of Life ◽

Clinical Research ◽

Life Assessment ◽

Research Projects ◽

Quality Of Life Assessment

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Controlled human infection with SARS-CoV-2 to study COVID-19 vaccines and treatments: bioethics in Utopia

Journal of Medical Ethics ◽

10.1136/medethics-2020-106476 ◽

2020 ◽

Vol 46 (9) ◽

pp. 569-573 ◽

Cited By ~ 3

Author(s):

Søren Holm

Keyword(s):

Informed Consent ◽

Severe Acute Respiratory Syndrome ◽

Healthy Volunteers ◽

Working Group ◽

Human Infection ◽

Social Value ◽

Scientific Quality ◽

Research Projects ◽

Selection Of

A number of papers have appeared recently arguing for the conclusion that it is ethically acceptable to infect healthy volunteers with severe acute respiratory syndrome coronavirus 2 as part of research projects aimed at developing COVID-19 vaccines or treatments. This position has also been endorsed in a statement by a working group for the WHO. The papers generally argue that controlled human infection (CHI) is ethically acceptable if (1) the risks to participants are low and therefore acceptable, (2) the scientific quality of the research is high, (3) the research has high social value, (4) participants give full informed consent, and (5) there is fair selection of participants. All five conditions are necessary premises in the overall argument that such research is ethically acceptable. The arguments concerning risk and informed consent have already been critically discussed in the literature. This paper therefore looks specifically at the arguments relating to condition 3 ‘high social value’ and condition 5 ‘fair selection of participants’ and shows that whereas they may be valid, they are not sound. It is highly unlikely that the conditions that are necessary for ethical CHI trials to take place will be fulfilled. Most, if not all, CHI trials will thus be well intentioned but unethical.

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The Scientific Quality of Child Custody Evaluations

PsycCRITIQUES ◽

10.1037/a0031189 ◽

2013 ◽

Vol 58 (22) ◽

Author(s):

Lennart Sjöberg

Keyword(s):

Child Custody ◽

Scientific Quality ◽

Custody Evaluations ◽

Child Custody Evaluations

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FUNDAMENTAL AND APPLIED SCIENTIFIC RESEARCH: сб.науч.тр./ OEAPS Inc.; редкол.: Флора Бертран (отв.ред.) [и др.]. - Берлин, Германия : OEAPS Inc., 2018. - 58 С.

10.31219/osf.io/hj4yf ◽

2018 ◽

Author(s):

Мария Григорьевна Алпатова ◽

Мария Игоревна Щеглова ◽

Elmira Kalybaevna Adil’bekova ◽

Nuradin Alibaev ◽

Arunas Svitojus

Keyword(s):

Service Sector ◽

Applied Research ◽

Point Of View ◽

Scientific Quality ◽

Final Decision ◽

Main Criterion ◽

The Public ◽

Peer Reviewers ◽

Verification Process

The conference is a major international forum for analyzing and discussing trends and approaches in research in the field of basic science and applied research. We provide a platform for discussions on innovative, theoretical and empirical research. The form of the conference: in absentia, without specifying the form in the collection of articles. Working languages: Russian, English Doctors and candidates of science, scientists, specialists of various profiles and directions, applicants for academic degrees, teachers, graduate students, undergraduates, students are invited to participate in the conference. There is one blind verification process in the journal. All articles will be initially evaluated by the editor for compliance with the journal. Manuscripts that are considered appropriate are then usually sent to at least two independent peer reviewers to assess the scientific quality of the article. The editor is responsible for the final decision on whether to accept or reject the article. The editor's decision is final. The main criterion used in assessing the manuscript submitted to the journal is: uniqueness or innovation in the work from the point of view of the methodology being developed and / or its application to a problem of particular importance in the public sector or service sector and / or the setting in which the efforts, for example, in the developing region of the world. That is, the very model / methodology, application and context of problems, at least one of them must be unique and important. Additional criteria considered in the consideration of the submitted document are its accuracy, organization / presentation (ie logical flow) and recording quality.

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FUNDAMENTAL AND APPLIED SCIENTIFIC RESEARCH April 2019: сб.науч.тр./ OEAPS Inc.; редкол.: Флора Бертран (отв.ред.) [и др.]. - Берлин, Германия : OEAPS Inc., 2019. - 98 C.

10.31219/osf.io/qmrey ◽

2019 ◽

Author(s):

Изабелла Станиславовна Чибисова ◽

Диана Ильгизаровна Шарипова ◽

Альфия Галиевна Зулькарнаева ◽

Ксения Александровна Дулова ◽

Садег Амирзадеган ◽

...

Keyword(s):

Service Sector ◽

Applied Research ◽

Point Of View ◽

Scientific Quality ◽

Final Decision ◽

Main Criterion ◽

The Public ◽

Peer Reviewers ◽

Verification Process

The conference is a major international forum for analyzing and discussing trends and approaches in research in the field of basic science and applied research. We provide a platform for discussions on innovative, theoretical and empirical research. The form of the conference: in absentia, without specifying the form in the collection of articles. Working languages: Russian, English Doctors and candidates of science, scientists, specialists of various profiles and directions, applicants for academic degrees, teachers, graduate students, undergraduates, students are invited to participate in the conference. There is one blind verification process in the journal. All articles will be initially evaluated by the editor for compliance with the journal. Manuscripts that are considered appropriate are then usually sent to at least two independent peer reviewers to assess the scientific quality of the article. The editor is responsible for the final decision on whether to accept or reject the article. The editor's decision is final. The main criterion used in assessing the manuscript submitted to the journal is: uniqueness or innovation in the work from the point of view of the methodology being developed and / or its application to a problem of particular importance in the public sector or service sector and / or the setting in which the efforts, for example, in the developing region of the world. That is, the very model / methodology, application and context of problems, at least one of them must be unique and important. Additional criteria considered in the consideration of the submitted document are its accuracy, organization / presentation (ie logical flow) and recording quality.

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Quality of life in primary sclerosing cholangitis: a systematic review

Health and Quality of Life Outcomes ◽

10.1186/s12955-021-01739-3 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Elena Marcus ◽

Paddy Stone ◽

Anna-Maria Krooupa ◽

Douglas Thorburn ◽

Bella Vivat

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Clinical Research ◽

Disease Progression ◽

Primary Sclerosing Cholangitis ◽

Sclerosing Cholangitis ◽

Small Sample ◽

Limited Evidence ◽

Research Studies

Abstract Background Primary sclerosing cholangitis (PSC) is a rare bile duct and liver disease which can considerably impact quality of life (QoL). As part of a project developing a measure of QoL for people with PSC, we conducted a systematic review with four review questions. The first of these questions overlaps with a recently published systematic review, so this paper reports on the last three of our initial four questions: (A) How does QoL in PSC compare with other groups?, (B) Which attributes/factors are associated with impaired QoL in PSC?, (C) Which interventions are effective in improving QoL in people with PSC?. Methods We systematically searched five databases from inception to 1 November 2020 and assessed the methodological quality of included studies using standard checklists. Results We identified 28 studies: 17 for (A), ten for (B), and nine for (C). Limited evidence was found for all review questions, with few studies included in each comparison, and small sample sizes. The limited evidence available indicated poorer QoL for people with PSC compared with healthy controls, but findings were mixed for comparisons with the general population. QoL outcomes in PSC were comparable to other chronic conditions. Itch, pain, jaundice, severity of inflammatory bowel disease, liver cirrhosis, and large-duct PSC were all associated with impaired QoL. No associations were found between QoL and PSC severity measured with surrogate markers of disease progression or one of three prognostic scoring systems. No interventions were found to improve QoL outcomes. Conclusion The limited findings from included studies suggest that markers of disease progression used in clinical trials may not reflect the experiences of people with PSC. This highlights the importance for clinical research studies to assess QoL alongside clinical and laboratory-based outcomes. A valid and responsive PSC-specific measure of QoL, to adequately capture all issues of importance to people with PSC, would therefore be helpful for clinical research studies.

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Preparation of irreversible hydrocolloids to improve retention of complete dentures

Medicinski pregled ◽

10.2298/mpns0804131a ◽

2008 ◽

Vol 61 (3-4) ◽

pp. 131-134

Author(s):

Ljiljana Aleksov ◽

Sasa Stankovic ◽

Zorica Ajdukovic

Keyword(s):

Clinical Research ◽

Dimensional Change ◽

Complete Dentures ◽

Consistency Analysis ◽

Working Models ◽

Retention Force ◽

Impression Materials ◽

Research Show

Introduction Precise reproduction of anatomical-morphological details of dentures support on working models presupposes adequate application of modern impression materials and casting procedure, as well as minimal dimensional change of these materials. The aim of the study: experimental and clinical research is connected to irreversible hydrocolloids and the objective was to examine the most suitable consistency of the alginate as the impression mass for the purpose of improving retention of complete dentures. Material and methods This research included 35 completely toothless patients, most of who had already had complete dentures, 40-80 years of age and of both sexes. Static adhesion was measured with aery late plates made of adequate corresponding and various models depending on consistency of the irreversible hydrocolloids. Each model was cut into three parts, the cuts obtained were mutually compared, and computerized graphic charts of each section were made. Results The results of the research show that there is a greater retention force in the acrylate plates obtained on models castled on an anatomical impression base taken with irreversible hydrocolloides of solid consistency. Analysis of the results shows such quality of impressed tissues that they are practically slightly displaced by the impressions regardless of the consistency of the material impressed. Conclusion In conclusion it is pointed out that the preparation of irreversible hydrocolloides must be carried out by strictly obeying the powder-water weight ratios. The sections of the models obtained by irreversible hydrocolloides of various consistencies, that is by applying different pressures, point to minimal displacement of tissues and great differences in the retention force in favor of the compressive impression.

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