Na/K-ATPase Ion Transport and Receptor-Mediated Signaling Pathways

Novel Ca receptor signaling pathways for control of renal ion transport

Current Opinion in Nephrology & Hypertension ◽

10.1097/mnh.0b013e328332e7b2 ◽

2010 ◽

Vol 19 (1) ◽

pp. 106-112 ◽

Cited By ~ 13

Author(s):

Chunfa Huang ◽

Richard Tyler Miller

Keyword(s):

Ion Transport ◽

Signaling Pathways ◽

Receptor Signaling

Download Full-text

Signaling pathways regulating ion transport in polarized cells

Epithelial Transport ◽

10.1007/978-94-009-1495-7_12 ◽

1996 ◽

pp. 256-274

Author(s):

Norman J. Karin ◽

Min I. N. Zhang ◽

E. Radford Decker ◽

Roger O’Neil

Keyword(s):

Ion Transport ◽

Signaling Pathways ◽

Polarized Cells

Download Full-text

In silico Gene Set and Pathway Enrichment Analyses Highlight Involvement of Ion Transport in Cholinergic Pathways in Autism: Rationale for Nutritional Intervention

Frontiers in Neuroscience ◽

10.3389/fnins.2021.648410 ◽

2021 ◽

Vol 15 ◽

Author(s):

Audrey Olson ◽

Fuquan Zhang ◽

Hongbao Cao ◽

Ancha Baranova ◽

Margaret Slavin

Keyword(s):

Ion Transport ◽

Signaling Pathways ◽

Signal Transmission ◽

Enrichment Analysis ◽

Gene Set Enrichment Analysis ◽

Gene Set Enrichment ◽

Gene Set ◽

Cholinergic Pathways ◽

Cholinergic Signaling ◽

Dietary Choline

Food is the primary human source of choline, an essential precursor to the neurotransmitter acetylcholine, which has a central role in signaling pathways that govern sensorimotor functions. Most Americans do not consume their recommended amount of dietary choline, and populations with neurodevelopmental conditions like autism spectrum disorder (ASD) may be particularly vulnerable to consequences of choline deficiency. This study aimed to identify a relationship between ASD and cholinergic signaling through gene set enrichment analysis and interrogation of existing database evidence to produce a systems biology model. In gene set enrichment analysis, two gene ontologies were identified as overlapping for autism-related and for cholinergic pathways-related functions, both involving ion transport regulation. Subsequent modeling of ion transport intensive cholinergic signaling pathways highlighted the importance of two genes with autism-associated variants: GABBR1, which codes for the gamma aminobutyric acid receptor (GABAB1), and KCNN2, which codes for calcium-activated, potassium ion transporting SK2 channels responsible for membrane repolarization after cholinergic binding/signal transmission events. Cholinergic signal transmission pathways related to these proteins were examined in the Pathway Studio environment. The ion transport ontological associations indicated feasibility of a dietary choline support as a low-risk therapeutic intervention capable of modulating cholinergic sensory signaling in autism. Further research at the intersection of dietary status and sensory function in autism is warranted.

Download Full-text

Hydrogen peroxide inhibits Ca 2+ ‐dependent chloride secretion across colonic epithelial cells via distinct kinase signaling pathways and ion transport proteins

The FASEB Journal ◽

10.1096/fj.07-099697 ◽

2008 ◽

Vol 22 (6) ◽

pp. 2023-2036 ◽

Cited By ~ 13

Author(s):

Alfred E. Chappell ◽

Michael Bunz ◽

Eric Smoll ◽

Hui Dong ◽

Christian Lytle ◽

...

Keyword(s):

Hydrogen Peroxide ◽

Epithelial Cells ◽

Ion Transport ◽

Signaling Pathways ◽

Chloride Secretion ◽

Transport Proteins ◽

Kinase Signaling ◽

Colonic Epithelial Cells

Download Full-text

A compendium of G-protein–coupled receptors and cyclic nucleotide regulation of adipose tissue metabolism and energy expenditure

Clinical Science ◽

10.1042/cs20190579 ◽

2020 ◽

Vol 134 (5) ◽

pp. 473-512 ◽

Cited By ~ 5

Author(s):

Ryan P. Ceddia ◽

Sheila Collins

Keyword(s):

Adipose Tissue ◽

Energy Expenditure ◽

Signaling Pathways ◽

G Protein ◽

Uncoupling Protein ◽

Beige Adipocytes ◽

Nucleotide Regulation ◽

Ucp1 Expression ◽

Thermogenic Adipocytes ◽

G Protein Coupled

Abstract With the ever-increasing burden of obesity and Type 2 diabetes, it is generally acknowledged that there remains a need for developing new therapeutics. One potential mechanism to combat obesity is to raise energy expenditure via increasing the amount of uncoupled respiration from the mitochondria-rich brown and beige adipocytes. With the recent appreciation of thermogenic adipocytes in humans, much effort is being made to elucidate the signaling pathways that regulate the browning of adipose tissue. In this review, we focus on the ligand–receptor signaling pathways that influence the cyclic nucleotides, cAMP and cGMP, in adipocytes. We chose to focus on G-protein–coupled receptor (GPCR), guanylyl cyclase and phosphodiesterase regulation of adipocytes because they are the targets of a large proportion of all currently available therapeutics. Furthermore, there is a large overlap in their signaling pathways, as signaling events that raise cAMP or cGMP generally increase adipocyte lipolysis and cause changes that are commonly referred to as browning: increasing mitochondrial biogenesis, uncoupling protein 1 (UCP1) expression and respiration.

Download Full-text