Suppressive effects of transcription factor GATA-1 on cell type-specific gene expression in dendritic cells

2010 ◽  
Vol 62 (7) ◽  
pp. 421-429 ◽  
Author(s):  
Naomi Shimokawa ◽  
Chiharu Nishiyama ◽  
Nobuhiro Nakano ◽  
Keiko Maeda ◽  
Ryuyo Suzuki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dendritic Cells ◽  
Transcription Factor ◽  
Specific Gene ◽  
Cell Type ◽  
Specific Gene Expression ◽  
Cell Type Specific

scholarly journals Transcription factor co-localization patterns affect human cell type-specific gene expression

BMC Genomics ◽  
2012 ◽  
Vol 13 (1) ◽  
pp. 263 ◽  
Author(s):  
Dennis Wang ◽  
Augusto Rendon ◽  
Willem Ouwehand ◽  
Lorenz Wernisch
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Human Cell ◽  
Specific Gene ◽  
Cell Type ◽  
Specific Gene Expression ◽  
Cell Type Specific

scholarly journals An integrated analysis of cell-type specific gene expression reveals genes regulated by REVOLUTA and KANADI1 in the Arabidopsis shoot apical meristem

PLoS Genetics ◽  
2020 ◽  
Vol 16 (4) ◽  
pp. e1008661 ◽  
Author(s):  
Hasthi Ram ◽  
Sudeep Sahadevan ◽  
Nittaya Gale ◽  
Monica Pia Caggiano ◽  
Xiulian Yu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Shoot Apical Meristem ◽  
Apical Meristem ◽  
Integrated Analysis ◽  
Specific Gene ◽  
Cell Type ◽  
Specific Gene Expression ◽  
Cell Type Specific

scholarly journals Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Takashi Ikeda ◽  
Takafusa Hikichi ◽  
Hisashi Miura ◽  
Hirofumi Shibata ◽  
Kanae Mitsunaga ◽  
...  
Keyword(s):  
Gene Expression ◽  
Specific Gene ◽  
Cell Type ◽  
Specific Gene Expression ◽  
Cell Type Specific ◽  
Cellular Identity

scholarly journals Distinct CoREST complexes act in a cell-type-specific manner

2019 ◽  
Author(s):  
Igor Mačinković ◽  
Ina Theofel ◽  
Tim Hundertmark ◽  
Kristina Kovač ◽  
Stephan Awe ◽  
...  
Keyword(s):  
Gene Expression ◽  
Germ Line ◽  
Protein Complexes ◽  
Specific Gene ◽  
S2 Cells ◽  
Cell Type ◽  
Specific Gene Expression ◽  
Genome Wide ◽  
A Cell ◽  
Cell Type Specific

Abstract CoREST has been identified as a subunit of several protein complexes that generate transcriptionally repressive chromatin structures during development. However, a comprehensive analysis of the CoREST interactome has not been carried out. We use proteomic approaches to define the interactomes of two dCoREST isoforms, dCoREST-L and dCoREST-M, in Drosophila. We identify three distinct histone deacetylase complexes built around a common dCoREST/dRPD3 core: A dLSD1/dCoREST complex, the LINT complex and a dG9a/dCoREST complex. The latter two complexes can incorporate both dCoREST isoforms. By contrast, the dLSD1/dCoREST complex exclusively assembles with the dCoREST-L isoform. Genome-wide studies show that the three dCoREST complexes associate with chromatin predominantly at promoters. Transcriptome analyses in S2 cells and testes reveal that different cell lineages utilize distinct dCoREST complexes to maintain cell-type-specific gene expression programmes: In macrophage-like S2 cells, LINT represses germ line-related genes whereas other dCoREST complexes are largely dispensable. By contrast, in testes, the dLSD1/dCoREST complex prevents transcription of germ line-inappropriate genes and is essential for spermatogenesis and fertility, whereas depletion of other dCoREST complexes has no effect. Our study uncovers three distinct dCoREST complexes that function in a lineage-restricted fashion to repress specific sets of genes thereby maintaining cell-type-specific gene expression programmes.

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