Evolution of a new nonclassical MHC class I locus in two Old World primate species

AbstractThe major histocompatibility complex (MHC) molecule plays a central role in the adaptive immunity of jawed vertebrates. Allelic variations have been studied extensively in some primate species, however a comprehensive description of the number of genes remains incomplete. Here, a bioinformatics program was developed to identify three MHC Class I exons (EX2, EX3 and EX4) from Whole Genome Sequencing (WGS) datasets. With this algorithm, MHC Class I exons sequences were extracted from 30 WGS datasets of primates, representatives of Apes, Old World and New World monkeys and prosimians. There is a high variability in the number of genes between species. From human WGS, six viable genes (HLA-A, -B, -C, -E, -F, and -G) and four pseudogene sequences (HLA-H, -J, -L, -V) are obtained. These genes serve to identify the phylogenetic clades of MHC-I in primates. The results indicate that human clades of HLA-A -B and -C were generated shortly after the separation of Old World monkeys. The clades pertaining to HLA-E, -H and -F are found in all primate families, except in Prosimians. In the clades defined by HLA-G, -L and -J, there are sequences from Old world monkeys. Specific clades are found in the four primate families. The evolution of these genes is consistent with birth and death processes having a high turnover rates.

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Faculty Opinions recommendation of An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1115502.571534 ◽

2008 ◽

Author(s):

Seiamak Bahram

Keyword(s):

T Cells ◽

Mhc Class I ◽

Class I ◽

Gammadelta T Cells ◽

Nonclassical Mhc ◽

Mhc Class I Molecules

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Faculty Opinions recommendation of Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717963564.793465769 ◽

2012 ◽

Author(s):

Eric Vivier ◽

Emilie Narni-Mancinelli

Keyword(s):

Nk Cells ◽

Mhc Class I ◽

Class I ◽

Mhc Class I Molecule ◽

Nonclassical Mhc

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II. One size fits all: nonclassical MHC molecules fulfill multiple roles in epithelial cell function

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.1998.274.2.g227 ◽

1998 ◽

Vol 274 (2) ◽

pp. G227-G231 ◽

Cited By ~ 3

Author(s):

Richard S. Blumberg

Keyword(s):

Epithelial Cell ◽

Mhc Class I ◽

Cell Biology ◽

Cell Function ◽

Surface Glycoprotein ◽

Class I ◽

Human Major Histocompatibility Complex ◽

Cell Surface Glycoprotein ◽

Mhc Molecules ◽

Nonclassical Mhc

The human major histocompatibility complex (MHC) on chromosome 6 encodes three classical class I genes: human leukocyte antigen-A (HLA-A), HLA-B, and HLA-C. These polymorphic genes encode a 43- to 45-kDa cell surface glycoprotein that, in association with the 12-kDa β2-microglobulin molecule, functions in the presentation of nine amino acid peptides to the T cell receptor of CD8-bearing T lymphocytes and killer inhibitory receptors on natural killer cells. In addition to these ubiquitously expressed polymorphic proteins, the human genome also encodes a number of nonclassical MHC class I-like, or class Ib, genes that in general encode nonpolymorphic molecules involved in a variety of specific immunologic functions. Many of these genes, including CD1, the neonatal Fc receptor for immunoglobulin G, HLA-G, the MHC class I chain-related gene A, and Hfe, are prominently displayed on epithelial cells, suggesting an important role in epithelial cell biology.

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A nonclassical MHC class I U lineage locus in zebrafish with a null haplotypic variant

Immunogenetics ◽

10.1007/s00251-015-0862-1 ◽

2015 ◽

Vol 67 (9) ◽

pp. 501-513 ◽

Cited By ~ 6

Author(s):

Hayley Dirscherl ◽

Jeffrey A. Yoder

Keyword(s):

Mhc Class I ◽

Class I ◽

Nonclassical Mhc

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Specialized function of the nonclassical MHC class I molecule Hmt: A specific receptor for N-formylated peptides

Immunologic Research ◽

10.1007/bf02919723 ◽

1991 ◽

Vol 10 (3-4) ◽

pp. 365-375 ◽

Cited By ~ 9

Author(s):

Said M. Shawar ◽

John R. Rodgers ◽

Richard G. Cook ◽

Robert R. Rich

Keyword(s):

Mhc Class I ◽

Class I ◽

Specific Receptor ◽

Mhc Class I Molecule ◽

Specialized Function ◽

Nonclassical Mhc

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Nonclassical MHC class I-dependent invariant T cells are evolutionarily conserved and prominent from early development in amphibians

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1309840110 ◽

2013 ◽

Vol 110 (35) ◽

pp. 14342-14347 ◽

Cited By ~ 41

Author(s):

E.-S. Edholm ◽

L.-M. Albertorio Saez ◽

A. L. Gill ◽

S. R. Gill ◽

L. Grayfer ◽

...

Keyword(s):

T Cells ◽

Mhc Class I ◽

Early Development ◽

Class I ◽

Evolutionarily Conserved ◽

Invariant T Cells ◽

Nonclassical Mhc

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The Major Histocompatibility Complex of Old World Camels—A Synopsis

Cells ◽

10.3390/cells8101200 ◽

2019 ◽

Vol 8 (10) ◽

pp. 1200 ◽

Cited By ~ 1

Author(s):

Plasil ◽

Wijkmark ◽

Elbers ◽

Oppelt ◽

Burger ◽

...

Keyword(s):

Major Histocompatibility Complex ◽

Mhc Class I ◽

Mhc Class Ii ◽

Class Ii ◽

Class I ◽

Class Iii ◽

Old World ◽

Histocompatibility Complex ◽

Mhc Class Iii ◽

Antigen Presenting

This study brings new information on major histocompatibility complex (MHC) class III sub-region genes in Old World camels and integrates current knowledge of the MHC region into a comprehensive overview for Old World camels. Out of the MHC class III genes characterized, TNFA and the LY6 gene family showed high levels of conservation, characteristic for MHC class III loci in general. For comparison, an MHC class II gene TAP1, not coding for antigen presenting molecules but functionally related to MHC antigen presenting functions was studied. TAP1 had many SNPs, even higher than the MHC class I and II genes encoding antigen presenting molecules. Based on this knowledge and using new camel genomic resources, we constructed an improved genomic map of the entire MHC region of Old World camels. The MHC class III sub-region shows a standard organization similar to that of pig or cattle. The overall genomic structure of the camel MHC is more similar to pig MHC than to cattle MHC. This conclusion is supported by differences in the organization of the MHC class II sub-region, absence of functional DY genes, different organization of MIC genes in the MHC class I sub-region, and generally closer evolutionary relationships of camel and porcine MHC gene sequences analyzed so far.

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