Chordoma: 18F-FDG PET/CT and MRI imaging features

Objective To investigate the characteristics of fluorine-18-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) maximum standardized uptake value (SUVmax) in primary intestinal lymphoma (PIL) and its correlation with D-dimer and lactate dehydrogenase (LDH). Methods Fifty-two patients diagnosed with PIL from June 2016 to December 2019 were analyzed. All patients underwent 18F-FDG PET/CT. The relationships between SUVmax and different pathological subtypes, clinical stages and risk grades were analyzed. The correlations between SUVmax and Ki-67, LDH and D-dimer were determined. Additionally, PET/CT imaging results were collected from 35 patients with primary intestinal cancer (PIC) and compared with the imaging features of PIL. Results SUVmax was significantly different between PIL and PIC groups and various PIL pathological subgroups. Patients in the high-risk PIL group had markedly higher SUVmax values than the intermediate-risk and low-risk groups. A significant positive correlation was observed between SUVmax and Ki-67 in patients with PIL. SUVmax was significantly different between the elevated and normal D-dimer groups. D-dimer showed a positive correlation with SUVmax. Conclusion 18F-FDG PET/CT SUVmax reflects the aggressiveness of lymphoma to a certain degree, is correlated with Ki-67 and determines the risk grades of PIL. Moreover, it facilitates differential diagnosis, clinical staging and treatment based on D-dimer levels.

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Comments on Fuster et al.: Prospective comparison of whole-body 18F-FDG PET/CT and MRI of the spine in the diagnosis of haematogenous spondylodiscitis

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-014-2920-6 ◽

2014 ◽

Vol 42 (2) ◽

pp. 355-355 ◽

Cited By ~ 1

Author(s):

Michael Soussan

Keyword(s):

Fdg Pet ◽

Whole Body ◽

Prospective Comparison ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct ◽

Ct And Mri

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Comparison of Gross Tumor Volume (GTV) determined by 18F-FDG PET/CT and MRI and paraortic limphadenectomy in radiotherapy planning in cervical cancer

Reports of Practical Oncology & Radiotherapy ◽

10.1016/j.rpor.2013.03.228 ◽

2013 ◽

Vol 18 ◽

pp. S228

Author(s):

S. Córdoba Largo ◽

J. Corona Sánchez ◽

M. Vázquez Masedo ◽

P. Alcántara Carrió ◽

A. Doval González ◽

...

Keyword(s):

Cervical Cancer ◽

Fdg Pet ◽

Gross Tumor Volume ◽

Tumor Volume ◽

Radiotherapy Planning ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct ◽

Ct And Mri

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18F FDG PET-CT Imaging in Tuberculosis

Bangladesh Journal of Nuclear Medicine ◽

10.3329/bjnm.v19i2.36011 ◽

2018 ◽

Vol 19 (2) ◽

pp. 135

Author(s):

Shamim MF Begum ◽

Md Abdus Shakur Khan

Keyword(s):

Computed Tomography ◽

Fdg Pet ◽

Ct Imaging ◽

Medical Emergency ◽

Imaging Features ◽

Conventional Imaging ◽

Imaging Tool ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

<p>Tuberculosis (TB) is the second highest infective cause of death worldwide and the global impact of TB is very important. Among all the TB burden WHO regions, 40% TB cases accounts in the South East Asian region. It has become a medical emergency not only in developing countries but also in some high-income countries. The rising incidence of multidrug resistance (MDR) TB and HIV co-infection has increased the morbidity and mortality of TB despite the availability of cheap and effective treatment. The diagnosis of active TB is almost similar over the world. Conventional radiography and Computed Tomography (CT) imaging play a crucial role in the diagnosis of TB. But these conventional imaging are often nonspecific and unable to provide a definitive diagnosis in cases of atypical and heterogeneous presentation. The signs of TB may mimic other diseases in conventional imaging. The introduction of new imaging tool Fluorine18 Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography (18F FDG PET-CT) opens the door to evaluate its potentiality application in TB. The role of this new imaging tool in TB imaging has been well documented. 18F FDG PET-CT may assist in early diagnosis, facilitate differentiation between malignancies and TB, identification of extrapulmonary TB, staging of TB, and in assessment of treatment response. Therefore, familiarity with the spectrum of imaging features and understanding the use of 18F FDG PET-CT in diagnosis and management of TB is important, especially for referring clinicians and the reporting nuclear medicine specialists in TB burden country like Bangladesh. This article reviews the main applications, pattern of imaging spectrum with limitations of 18F FDG PET-CT in TB.</p><p>Bangladesh J. Nuclear Med. 19(2): 135-140, July 2016</p>

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Imaging features and prognostic value of 18F-FDG PET/CT detection of soft-tissue metastasis from lung cancer: a retrospective study

BMC Cancer ◽

10.1186/s12885-020-07080-0 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Tingting Xu ◽

Xinyi Zhang ◽

Shumao Zhang ◽

Chunfeng Liu ◽

Wenhui Fu ◽

...

Keyword(s):

Lung Cancer ◽

Retrospective Study ◽

Soft Tissue ◽

Fdg Pet ◽

Prognostic Value ◽

Imaging Features ◽

Soft Tissue Metastasis ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Comparison of the Diagnostic Value of MRI and Whole Body 18F-FDG PET/CT in Diagnosis of Spondylodiscitis

Journal of Clinical Medicine ◽

10.3390/jcm9051581 ◽

2020 ◽

Vol 9 (5) ◽

pp. 1581

Author(s):

Corinna Altini ◽

Valentina Lavelli ◽

Artor Niccoli-Asabella ◽

Angela Sardaro ◽

Alessia Branca ◽

...

Keyword(s):

Fdg Pet ◽

Diagnostic Value ◽

Whole Body ◽

Spine Infection ◽

Positron Emission ◽

Pet Ct ◽

18F Fdg ◽

Sensitivity Specificity ◽

Fdg Pet Ct ◽

Ct And Mri

Spondylodiscitis is a spine infection for which a diagnosis by a magnetic resonance imaging (MRI) is considered the most appropriate imaging technique. The aim of this study was to compare the role of an 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and an MRI in this field. For 56 patients with suspected spondylodiscitis for whom MRI and 18F-FDG PET/CT were performed, we retrospectively analyzed the results. Cohen’s κ was applied to evaluate the agreement between the two techniques in all patients and in subgroups with a different number of spinal districts analyzed by the MRI. Sensitivity, specificity, and accuracy were also evaluated. The agreements of the 18F-FDG PET/CT and MRI in the evaluation of the entire population, whole-spine MRI, and two-districts MRI were moderate (κ = 0.456, κ = 0.432, and κ = 0.429, respectively). In patients for whom one-district MRI was performed, 18F-FDG PET/CT and MRI were both positive and completely concordant (κ = 1). We also separately evaluated patients with suspected spondylodiscitis caused by Mycobacterium tuberculosis for whom the MRI and 18F-FDG PET/CT were always concordant excepting in 2 of the 18 (11%) patients. Sensitivity, specificity, and accuracy of the MRI and 18F-FDG PET/CT were 100%, 60%, 97%, and 92%, 100%, and 94%, respectively. Our results confirmed the 18F-FDG PET/CT diagnostic value in the diagnosis of spondylodiscitis is comparable to that of MRI for the entire spine evaluation. This could be considered a complementary technique or a valid alternative to MRI.

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