Combination transarterial chemoembolization and microwave ablation improves local tumor control for 3- to 5-cm hepatocellular carcinoma when compared with transarterial chemoembolization alone

2018 ◽  
Vol 43 (9) ◽  
pp. 2497-2504 ◽  
Author(s):  
Amanda R. Smolock ◽  
Mircea M. Cristescu ◽  
Audrey Hinshaw ◽  
Kaitlin M. Woo ◽  
Shane A. Wells ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transarterial Chemoembolization ◽  
Microwave Ablation ◽  
Local Tumor Control ◽  
Tumor Control ◽  
Local Tumor

scholarly journals Small single perivascular hepatocellular carcinoma: comparisons of radiofrequency ablation and microwave ablation by using propensity score analysis

2021 ◽  
Author(s):  
Chao An ◽  
Wang-Zhong Li ◽  
Zhi-Mei Huang ◽  
Xiao-Ling Yu ◽  
Yu-Zhi Han ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Tumor Progression ◽  
Significant Interaction ◽  
Microwave Ablation ◽  
Disease Free Survival ◽  
Tumor Control ◽  
Local Tumor Progression ◽  
Local Tumor ◽  
First Line

Abstract Objectives We aimed to compare the therapeutic outcomes of radiofrequency ablation (RFA) and microwave ablation (MWA) as first-line therapies in patients with small single perivascular hepatocellular carcinoma (HCC). Methods A total of 144 eligible patients with small (≤ 3 cm) single perivascular (proximity to hepatic and portal veins) HCC who underwent RFA (N = 70) or MWA (N = 74) as first-line treatment were included. The overall survival (OS), disease-free survival (DFS), and local tumor progression (LTP) rates between the two ablation modalities were compared. The inverse probability of treatment weighting (IPTW) method was used to reduce selection bias. Subgroup analysis was performed according to the type of hepatic vessels. Results After a median follow-up time of 38.2 months, there were no significant differences in OS (5-year OS: RFA 77.7% vs. MWA 74.6%; p = 0.600) and DFS (5-year DFS: RFA 24.7% vs. MWA 40.4%; p = 0.570). However, a significantly higher LTP rate was observed in the RFA group than the MWA group (5-year LTP: RFA 24.3% vs. MWA 8.4%; p = 0.030). IPTW-adjusted analyses revealed similar results. The treatment modality (RFA vs. MWA: HR 7.861, 95% CI 1.642–37.635, p = 0.010) was an independent prognostic factor for LTP. We observed a significant interaction effect of ablation modality and type of peritumoral vessel on LTP (p = 0.034). For patients with periportal HCC, the LTP rate was significantly higher in the RFA group than in the MWA group (p = 0.045). However, this difference was not observed in patients with perivenous HCC (p = 0.116). Conclusions In patients with a small single periportal HCC, MWA exhibited better tumor control than RFA. Key Points • Microwave ablation exhibited better local tumor control than radiofrequency ablation for small single periportal hepatocellular carcinoma. • There was a significant interaction between the treatment effect of ablation modality and type of peritumoral vessel on local tumor progression. • The type of peritumoral vessel is vital in choosing ablation modalities for hepatocellular carcinoma.

scholarly journals Association between Time to Local Tumor Control and Treatment Outcomes Following Repeated Loco-Regional Treatment Session in Patients with Hepatocellular Carcinoma: A RETROSPECTIVE, Single-Center Study

Life ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1062
Author(s):  
Krzysztof Bartnik ◽  
Wacław Hołówko ◽  
Olgierd Rowiński
Keyword(s):  
Hepatocellular Carcinoma ◽  
Treatment Outcomes ◽  
Independent Predictor ◽  
Univariate Analysis ◽  
Progression Free Survival ◽  
Local Tumor Control ◽  
Primary Study ◽  
Tumor Control ◽  
Local Tumor ◽  
Regional Treatment

Background: Whether the number of loco-regional treatment sessions and the time required to obtain local tumor control (LTC) affects the prognosis of patients with hepatocellular carcinoma (HCC) remains controversial. This study aimed to determine whether a longer time to LTC is a significant and independent predictor of poor treatment outcomes. Methods: In this retrospective study, we analyzed data of 139 treatment-naive patients with HCC who were not eligible for a treatment other than transarterial chemoembolization (TACE) at baseline. The outcome analyses were performed using the Cox proportional hazard model and Kaplan–Meier method, while the overall survival (OS) and progression free survival (PFS) were the primary study endpoints. Results: Overall, LTC was achieved in 82 (59%) of patients, including 67 (81%) patients who achieved LTC following TACE sessions alone and 15 (19%) subjects required additional ablation session. The median OS did not differ significantly between groups that needed 2, 3, or >3 locoregional treatment sessions to achieve LTC (p = 0.37). Longer time to LTC (in weeks) was significantly associated with shorter OS in univariate analysis (p = 0.04), but not in an adjusted model (p = 0.14). Both univariate and adjusted analyses showed that longer time to reach LTC was significantly associated with shorter PFS (adjusted HR = 1.04, 95% CI 1.001–1.09, p = 0.048). Conclusions: These findings show that the longer time to LTC is not an independent predictor of OS, but suggest that PFS may be significantly shorter in patients with longer time to LTC.

Factors Influencing Local Tumor Control in Patients With Neoplastic Pulmonary Nodules Treated With Microwave Ablation: A Risk-Factor Analysis

2013 ◽  
Vol 200 (3) ◽  
pp. 665-672 ◽  
Author(s):  
Thomas J. Vogl ◽  
Thomas S. Worst ◽  
Nagy N. N. Naguib ◽  
Hanns Ackermann ◽  
Tatjana Gruber-Rouh ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Risk Factor ◽  
Microwave Ablation ◽  
Pulmonary Nodules ◽  
Local Tumor Control ◽  
Risk Factor Analysis ◽  
Tumor Control ◽  
Local Tumor ◽  
Factors Influencing
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