Squamous cell carcinoma cells differentially stimulate NK cell effector functions: the role of IL-18

2003 ◽  
Vol 52 (2) ◽  
pp. 107-115 ◽  
Author(s):  
Mikel B. Moore ◽  
Zoya B. Kurago ◽  
Colleen A. Fullenkamp ◽  
Charles T. Lutz
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Nk Cell ◽  
Carcinoma Cells ◽  
Effector Functions ◽  
Cell Effector

scholarly journals Metformin sensitizes the response of oral squamous cell carcinoma to cisplatin treatment through inhibition of NF-κB/HIF-1α signal axis

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Xiaofeng Qi ◽  
Wengguang Xu ◽  
Junqi Xie ◽  
Yufeng Wang ◽  
Shengwei Han ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Oral Cancers ◽  
Underlying Mechanisms

Abstract Resistance towards chemotherapy is a common complication in treatment of oral cancers, which leads to treatment failure and poor outcome. In recent years, a growing body of evidence has shown that tumour hypoxia significantly contributes to chemoresistance. Metformin, a widely used oral hypoglycaemic drug, can reportedly potentiate the efficacy of chemotherapeutic drugs in various cancers; however, the underlying mechanisms are intricate and have not been fully understood. In this study, we explored the role of metformin in chemosensitivity of oral squamous cell carcinoma cells (OSCC) to cisplatin both in vitro and in vivo, and attempted to elucidate its possible underlying mechanisms. Encouragingly, we found that metformin synergistically enhanced cisplatin cytotoxicity and reversed the chemoresistance to certain extent. This mechanism could likely be related with inhibition of the NF-κB/HIF-1α signal axis and lead to the downregulation of hypoxia-regulated genes products. Therefore, metformin could serve as a chemosensitiser for cisplatin-based regimens for OSCC, thereby providing a theoretical basis for future use in the treatment of oral cancers.

scholarly journals Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cells

2009 ◽  
Vol 58 (11) ◽  
pp. 1853-1862 ◽  
Author(s):  
Andrés López-Albaitero ◽  
Steve C. Lee ◽  
Sarah Morgan ◽  
Jennifer R. Grandis ◽  
William E. Gooding ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Nk Cell ◽  
In Vitro Cytotoxicity ◽  
Carcinoma Cells ◽  
Fc Gamma Receptor ◽  
Gamma Receptor ◽  
Egfr Expression

The role of dihydropyrimidine dehydrogenase expression in resistance to 5-fluorouracil in head and neck squamous cell carcinoma cells

Oral Oncology ◽  
2009 ◽  
Vol 45 (2) ◽  
pp. 141-147 ◽  
Author(s):  
Ryuji Yasumatsu ◽  
Torahiko Nakashima ◽  
Hideoki Uryu ◽  
Muneyuki Masuda ◽  
Naoya Hirakawa ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Dihydropyrimidine Dehydrogenase ◽  
Carcinoma Cells ◽  
Neck Squamous Cell Carcinoma

scholarly journals Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cells

2009 ◽  
Vol 58 (11) ◽  
pp. 1863-1864 ◽  
Author(s):  
Andrés López-Albaitero ◽  
Steve C. Lee ◽  
Sarah Morgan ◽  
Jennifer R. Grandis ◽  
William E. Gooding ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Nk Cell ◽  
In Vitro Cytotoxicity ◽  
Carcinoma Cells ◽  
Fc Gamma Receptor ◽  
Gamma Receptor ◽  
Egfr Expression

scholarly journals Significant Role of Collagen XVII And Integrin β4 in Migration and Invasion of The Less Aggressive Squamous Cell Carcinoma Cells

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jyri M. Moilanen ◽  
Stefanie Löffek ◽  
Nina Kokkonen ◽  
Sirpa Salo ◽  
Juha P. Väyrynen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Significant Role ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Migration And Invasion ◽  
Collagen Xvii ◽  
Integrin Β4

scholarly journals The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells

2011 ◽  
Vol 131 (2) ◽  
pp. 287-297 ◽  
Author(s):  
Alan Serrels ◽  
Kenneth McLeod ◽  
Marta Canel ◽  
Andrew Kinnaird ◽  
Kathryn Graham ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Catalytic Activity ◽  
Cell Carcinoma ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
And Migration ◽  
Proliferation And Migration
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