scholarly journals Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma

2017 ◽  
Vol 66 (9) ◽  
pp. 1217-1228 ◽  
Author(s):  
Roger Gilabert-Oriol ◽  
Sebastian G. B. Furness ◽  
Brett W. Stringer ◽  
Alexander Weng ◽  
Hendrik Fuchs ◽  
...  
Keyword(s):  
Cell Lines ◽  
Glioma Cell ◽  
High Grade Glioma ◽  
High Grade ◽  
Calcitonin Receptor ◽  
Receptor Antibody ◽  
Glioma Cell Lines

scholarly journals Proteomic analysis of human glioblastoma cell lines differently resistant to a nitric oxide releasing agent

2015 ◽  
Vol 11 (6) ◽  
pp. 1612-1621 ◽  
Author(s):  
Roberta Leone ◽  
Paola Giussani ◽  
Sara De Palma ◽  
Chiara Fania ◽  
Daniele Capitanio ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Lines ◽  
Glioma Cell ◽  
High Grade Glioma ◽  
High Grade ◽  
Glioblastoma Cell ◽  
Proteomic Profile ◽  
Glioma Cell Lines ◽  
Nitric Oxide Releasing ◽  
Glioblastoma Cell Lines

NO exposure of two human high grade glioma cell lines (CCF-STTG1 and T98G) characterized by a different proteomic profile shows differential ceramide distribution and proliferation.

scholarly journals Comparison of 99mTc-Tetrofosmin and 99mTc-Sestamibi Uptake in Glioma Cell Lines: The Role of P-Glycoprotein Expression

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
George A. Alexiou ◽  
Xanthi Xourgia ◽  
Evrysthenis Vartholomatos ◽  
Spyridon Tsiouris ◽  
John A. Kalef-Ezra ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cell Line ◽  
Cell Lines ◽  
Glioma Cell ◽  
Tumor Imaging ◽  
High Grade Glioma ◽  
High Grade ◽  
P Glycoprotein ◽  
99Mtc Tetrofosmin ◽  
Glioma Cell Lines

Tc-Tetrofosmin (Tc-TF) and Tc-Sestamibi (Tc-MIBI) are SPECT tracers that have been used for brain tumor imaging. Tumor’s multidrug resistance phenotype, namely, P-glycoprotein (p-gp), and the multidrug resistance related proteins (MRPs) expression have been suggested to influence both tracers’ uptake. In the present study we set out to compare Tc-MIBI uptake in high-grade glioma cell lines and to investigate the influence of gliomas p-gp expression on both tracers’ uptake. We used four glioma cell lines (U251MG, A172, U87MG, and T98G). The expression of p-gp protein was evaluated by flow cytometry. Twenty μCi (7.4·105 Bq) of Tc-TF and Tc-MIBI were used. The radioactivity in the cellular lysate was measured with a dose calibrator. P-gp was significantly expressed only in the U251MG cell line (). In all gliomas cell lines (U251MG, U87MG, A172, and T98G) the Tc-TF uptake was significantly higher than Tc-sestamibi. The U251MG cell line, in which significant p-gp expression was documented, exhibited the strongest uptake difference. Tc-TF uptake was higher than Tc-MIBI in all studied high-grade glioma cell lines. Thus, Tc-TF may be superior to Tc-MIBI for glioma imaging in vivo.

scholarly journals EGFRvIII Deletion Mutations in Pediatric High-Grade Glioma and Response to Targeted Therapy in Pediatric Glioma Cell Lines

2009 ◽  
Vol 15 (18) ◽  
pp. 5753-5761 ◽  
Author(s):  
Dorine A. Bax ◽  
Nathalie Gaspar ◽  
Suzanne E. Little ◽  
Lynley Marshall ◽  
Lara Perryman ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Cell Lines ◽  
Glioma Cell ◽  
High Grade Glioma ◽  
High Grade ◽  
Pediatric Glioma ◽  
Deletion Mutations ◽  
Glioma Cell Lines ◽  
Pediatric High Grade Glioma

scholarly journals PCM-13THE HYPOXIA-ACTIVATED PRODRUG EVOFOSFAMIDE (TH-302) IS EFFICACIOUS IN PEDIATRIC HIGH GRADE GLIOMA CELL LINES AS A MONOTHERAPY AND IN COMBINATION WITH CHEMOTHERAPIES

2016 ◽  
Vol 18 (suppl 3) ◽  
pp. iii141.5-iii142
Author(s):  
Pierre Leblond ◽  
Pauline Navarin ◽  
Mélanie Arcicasa ◽  
Christine Bal-Mahieu ◽  
Nicole Lemahieu ◽  
...  
Keyword(s):  
Cell Lines ◽  
Glioma Cell ◽  
High Grade Glioma ◽  
High Grade ◽  
Glioma Cell Lines ◽  
Pediatric High Grade Glioma

scholarly journals Novel cancer-testis antigen expression on glioma cell lines derived from high-grade glioma patients

2014 ◽  
Vol 31 (4) ◽  
pp. 1683-1690 ◽  
Author(s):  
YASUTO AKIYAMA ◽  
MASARU KOMIYAMA ◽  
HARUO MIYATA ◽  
MIKA YAGOTO ◽  
TADASHI ASHIZAWA ◽  
...  
Keyword(s):  
Cell Lines ◽  
Glioma Cell ◽  
Antigen Expression ◽  
High Grade Glioma ◽  
High Grade ◽  
Cancer Testis Antigen ◽  
Glioma Cell Lines ◽  
Cancer Testis

scholarly journals Differential Expression of miRNAs in Hypoxia (“HypoxamiRs”) in Three Canine High-Grade Glioma Cell Lines

2020 ◽  
Vol 7 ◽  
Author(s):  
Jennifer Koehler ◽  
Maninder Sandey ◽  
Nripesh Prasad ◽  
Shawn A. Levy ◽  
Xiaozhu Wang ◽  
...  
Keyword(s):  
Differential Expression ◽  
Cell Lines ◽  
Glioma Cell ◽  
High Grade Glioma ◽  
High Grade ◽  
Glioma Cell Lines
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