Aberrant peripheral blood CD4+ CD25+ FOXP3+ regulatory T cells/T helper-17 number is associated with the outcome of patients with lymphoma

2020 ◽  
Vol 69 (9) ◽  
pp. 1917-1928 ◽  
Author(s):  
Mehdi Dehghani ◽  
Mehdi Kalani ◽  
Hossein Golmoghaddam ◽  
Mani Ramzi ◽  
Nargess Arandi
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Peripheral Blood ◽  
T Helper ◽  
T Helper 17

scholarly journals Notch signaling pathway regulates CD4+CD25+CD127dim/− regulatory T cells and T helper 17 cells function in gastric cancer patients

2019 ◽  
Vol 39 (5) ◽  
Author(s):  
Lu Yang ◽  
Ke-Lei Zhao ◽  
Lei Qin ◽  
Dan-Xia Ji ◽  
Bin Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Cells ◽  
Regulatory T Cells ◽  
Notch Signaling ◽  
Cancer Progression ◽  
Th17 Cells ◽  
Cellular Proliferation ◽  
Current Data ◽  
T Helper ◽  
T Helper 17

Abstract Regulatory T cells (Tregs) and T helper 17 (Th17) cells contribute to cancer progression and prognosis. However, regulatory factors associated with Tregs–Th17 balance were not completely understood. We previously demonstrated an immune-modulatory capacity by Notch signaling inactivation to reverse Tregs–Th17 disequilibrium in chronic hepatitis C. Thus, the aim of current study was to assess the role of Notch signaling in modulation Tregs and Th17 cells function in gastric cancer (GC) patients. A total of 51 GC patients and 18 normal controls (NCs) were enrolled. Notch1 and Notch2 mRNA expressions were semiquantified by real-time polymerase chain reaction. Tregs/Th17 percentages, transcriptional factors, and cytokines production were investigated in response to the stimulation of Notch signaling inhibitor DAPT. Both Notch1 and Notch2 mRNA expressions were elevated in GC tissues and peripheral bloods in GC patients. CD4+CD25+CD127dim/− Tregs and Th17 cells percentage was also elevated in GC patients compared with in NCs. DAPT treatment did not affect frequency of either circulating Tregs or Th17 cells, however, reduced FoxP3/RORγt mRNA expression and interleukin (IL)-35/IL-17 production in purified CD4+ T cells from GC patients. Moreover, blockade of Notch signaling also inhibited the suppressive function of purified CD4+CD25+CD127dim/− Tregs from GC patients, which presented as elevation of cellular proliferation and IL-35 secretion. The current data further provided mechanism underlying Tregs–Th17 balance in GC patients. The link between Notch signaling and Th cells might lead to a new therapeutic target for GC patients.

IL-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-helper-17 Cells at the Expense of Regulatory T cells: Implications for the Timing of Tolerizing Immunotherapy

2010 ◽  
Vol 135 ◽  
pp. S98
Author(s):  
Sebastien Bertin-Maghit ◽  
Brendan O'Sullivan ◽  
Shannoiin Best ◽  
Emily Duggan ◽  
Dimeng Pang ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
T Helper ◽  
T Helper 17 ◽  
T Helper 17 Cells

scholarly journals Quantitative proteomic characterization and comparison of T helper 17 and induced regulatory T cells

PLoS Biology ◽  
2018 ◽  
Vol 16 (5) ◽  
pp. e2004194 ◽  
Author(s):  
Imran Mohammad ◽  
Kari Nousiainen ◽  
Santosh D. Bhosale ◽  
Inna Starskaia ◽  
Robert Moulder ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
T Helper ◽  
T Helper 17

scholarly journals The Microbiota and Epigenetic Regulation of T Helper 17/Regulatory T Cells: In Search of a Balanced Immune System

2017 ◽  
Vol 8 ◽  
Author(s):  
Annie Luo ◽  
Steven T. Leach ◽  
Romain Barres ◽  
Luke B. Hesson ◽  
Michael C. Grimm ◽  
...  
Keyword(s):  
T Cells ◽  
Immune System ◽  
Regulatory T Cells ◽  
Epigenetic Regulation ◽  
T Helper ◽  
T Helper 17

scholarly journals FOXP3+ Regulatory T Cells and T Helper 1, T Helper 2, and T Helper 17 Cells in Human Early Pregnancy Decidua1

2010 ◽  
Vol 82 (4) ◽  
pp. 698-705 ◽  
Author(s):  
Jenny Mjösberg ◽  
Göran Berg ◽  
Maria C. Jenmalm ◽  
Jan Ernerudh
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Early Pregnancy ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 17 ◽  
T Helper 17 Cells ◽  
T Helper 2

scholarly journals Transforming Growth Factor-β Signaling in Regulatory T Cells Controls T Helper-17 Cells and Tissue-Specific Immune Responses

Immunity ◽  
2017 ◽  
Vol 46 (4) ◽  
pp. 660-674 ◽  
Author(s):  
Joanne E. Konkel ◽  
Dunfang Zhang ◽  
Peter Zanvit ◽  
Cheryl Chia ◽  
Tamsin Zangarle-Murray ◽  
...  
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
Regulatory T Cells ◽  
Immune Responses ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
T Helper ◽  
T Helper 17 ◽  
T Helper 17 Cells ◽  
Tissue Specific
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