Diagnostic value of necrotic lesion boundary in bone collapse of femoral head osteonecrosis

2021 ◽  
Author(s):  
Yinuo Fan ◽  
Jiahao Zhang ◽  
Minghai Chen ◽  
Fengxiang Pang ◽  
Haicheng Chen ◽  
...  
Keyword(s):  
Femoral Head ◽  
Diagnostic Value ◽  
Necrotic Lesion ◽  
Femoral Head Osteonecrosis

Prediction of collapse in femoral head osteonecrosis: role of volumetric assessment

2020 ◽  
pp. 112070002097858
Author(s):  
Sajid Ansari ◽  
Tarun Goyal ◽  
Roop B Kalia ◽  
Souvik Paul ◽  
Sanny Singh
Keyword(s):  
Survival Analysis ◽  
Femoral Head ◽  
Lesion Size ◽  
Necrotic Lesion ◽  
Rank Test ◽  
Lesion Volume ◽  
Femoral Head Osteonecrosis ◽  
Volumetric Assessment ◽  
Angular Measurements ◽  
Stage 1

Purpose: The purpose of this study was to evaluate and compare the accuracy of three different techniques of measuring the extent of osteonecrosis involvement of the femoral head on MRI to determine the best predictor of collapse and to identify the size of the lesion volume which best predicts collapse. Methods: We prospectively enrolled 48 hips of osteonecrosis femoral head (ONFH) with stage 1 or 2 osteonecrosis and the enrolled patients were followed up for 1 year. Angular measurements (modified Kerboul Angle and modified index of necrotic extent) were compared with the 3D volumetric measurement of necrotic lesion based on MRI in predicting the collapse of the head. ROC analysis was done to evaluate the diagnostic performance of the 3 indices in predicting collapse. Survival analysis of all the hips in the collapsed and non-collapsed group were interpreted using Kaplan Meir survival analysis. Results: In lesion sizes larger than 25% of femoral head volume - 90.6% (29/32) of hips collapsed within 1 year as compared to 31.3% (5/16) hips collapsed in lesion volume <25% of femoral head (Log-rank test p = 0.001). There was good inter-observer (ICC, 0.94; 95% CI, 0.89–0.97) and intra-observer reliability (ICC, 0.93; 95% CI, 0.88–0.96). Conclusions: The Volumetric method assessed the severity of lesion size with the future collapse better and more predictably than angular measurements. Necrotic lesion volume of 25% is a potential cut off beyond which future collapse of early ONFH can be predicted and aid in the further management. This study can help in solving the mystery behind prediction of collapse in ONFH.

The effect of corticosteroids on development of femoral head osteonecrosis in patients after kidney transplantation

2017 ◽  
Author(s):  
Enis Gursel ◽  
Omer Faruk Bilgen ◽  
Sadik Bilgen ◽  
Basak Erdemli Gursel ◽  
Canan Ersoy ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Femoral Head ◽  
Femoral Head Osteonecrosis

Epidemiological Study of Femoral Head Osteonecrosis

2017 ◽  
Vol 68 (5) ◽  
pp. 974-976
Author(s):  
Alexandru Patrascu ◽  
Liliana Savin ◽  
Dan Mihailescu ◽  
Victor Grigorescu ◽  
carmen Grierosu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Femoral Head ◽  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Young Patients ◽  
Head Group ◽  
Bipolar Hemiarthroplasty ◽  
Aseptic Necrosis ◽  
Total Hip ◽  
Femoral Head Osteonecrosis

In recent years, there has been an increase in the number of studies on the etiology of femoral head necrosis. We retrospectively reviewed all patients diagnosed with aseptic necrosis of the femoral in the period of 2010-2015. We recorded a total of 230 cases diagnosed with aseptic necrosis of the femoral head, group was composed of 65.7% men and 34.3% women, risk factors identified was 19.13% (post-traumatic), 13.91% (glucocorticoids), 26.52% (alcohol), 3.47% (another cause) and in 36 95% of the cases no risk factors were found. The results of the study based on the type of surgery performed on the basis of stages of disease progression, 8 patients (3.48%) benefited from osteotomy, 28 patients (12.17%) benefited of bipolar hemiarthroplasty prosthesis and 188 patients (81.74%) benefited of total hip arthroplasty. Osteonecrosis of the femoral head is characteristic to young patients between the age of 30-50 years old. Predisposing factors, alcohol and corticosteroid therapy remains an important cause of the disease. Total hip arthroplasty remains the best option for the patients with osteonecrosis of the femoral head.

scholarly journals Outcome after a new porous tantalum rod implantation for treatment of early-stage femoral head osteonecrosis

2019 ◽  
Vol 7 (18) ◽  
pp. 441-441 ◽  
Author(s):  
Wei Huang ◽  
Xuan Gong ◽  
Steve Sandiford ◽  
Xiaoqiang He ◽  
Feilong Li ◽  
...  
Keyword(s):  
Femoral Head ◽  
Early Stage ◽  
Porous Tantalum ◽  
Femoral Head Osteonecrosis

scholarly journals HEMGN and SLC2A1 might be potential diagnostic biomarkers of steroid-induced osteonecrosis of femoral head: study based on WGCNA and DEGs screening

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Zhixin Wu ◽  
Yinxian Wen ◽  
Guanlan Fan ◽  
Hangyuan He ◽  
Siqi Zhou ◽  
...  
Keyword(s):  
Femoral Head ◽  
Roc Curve ◽  
Enrichment Analysis ◽  
Diagnostic Value ◽  
Functional Enrichment ◽  
Pathway Enrichment Analysis ◽  
Overlapping Genes ◽  
Hub Genes ◽  
Diagnostic Biomarkers ◽  
Key Genes

Abstract Background Steroid-induced osteonecrosis of the femoral head (SONFH) is a chronic and crippling bone disease. This study aims to reveal novel diagnostic biomarkers of SONFH. Methods The GSE123568 dataset based on peripheral blood samples from 10 healthy individuals and 30 SONFH patients was used for weighted gene co-expression network analysis (WGCNA) and differentially expressed genes (DEGs) screening. The genes in the module related to SONFH and the DEGs were extracted for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Genes with |gene significance| > 0.7 and |module membership| > 0.8 were selected as hub genes in modules. The DEGs with the degree of connectivity ≥5 were chosen as hub genes in DEGs. Subsequently, the overlapping genes of hub genes in modules and hub genes in DEGs were selected as key genes for SONFH. And then, the key genes were verified in another dataset, and the diagnostic value of key genes was evaluated by receiver operating characteristic (ROC) curve. Results Nine gene co-expression modules were constructed via WGCNA. The brown module with 1258 genes was most significantly correlated with SONFH and was identified as the key module for SONFH. The results of functional enrichment analysis showed that the genes in the key module were mainly enriched in the inflammatory response, apoptotic process and osteoclast differentiation. A total of 91 genes were identified as hub genes in the key module. Besides, 145 DEGs were identified by DEGs screening and 26 genes were identified as hub genes of DEGs. Overlapping genes of hub genes in the key module and hub genes in DEGs, including RHAG, RNF14, HEMGN, and SLC2A1, were further selected as key genes for SONFH. The diagnostic value of these key genes for SONFH was confirmed by ROC curve. The validation results of these key genes in GSE26316 dataset showed that only HEMGN and SLC2A1 were downregulated in the SONFH group, suggesting that they were more likely to be diagnostic biomarkers of SOFNH than RHAG and RNF14. Conclusions Our study identified that two key genes, HEMGN and SLC2A1, might be potential diagnostic biomarkers of SONFH.

A poly(propylene fumarate) – Calcium phosphate based angiogenic injectable bone cement for femoral head osteonecrosis

Biomaterials ◽  
2010 ◽  
Vol 31 (14) ◽  
pp. 4048-4055 ◽  
Author(s):  
Chih-Hung Chang ◽  
Tai-Chieh Liao ◽  
Yuan-Ming Hsu ◽  
Hsu-Wei Fang ◽  
Chia-Chun Chen ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Femoral Head ◽  
Bone Cement ◽  
Femoral Head Osteonecrosis ◽  
Poly Propylene

Septic arthritis of the hip in patients with femoral head osteonecrosis

2011 ◽  
Vol 131 (11) ◽  
pp. 1585-1590 ◽  
Author(s):  
Young-Kyun Lee ◽  
Yun Jong Lee ◽  
Yong-Chan Ha ◽  
Ki-Choul Kim ◽  
Kyung-Hoi Koo
Keyword(s):  
Femoral Head ◽  
Septic Arthritis ◽  
Femoral Head Osteonecrosis

Recent Methods of Neck Femur Fixation A Systematic review and meta-analysis

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Ahmed Salem Eid ◽  
Ahmed Mohamed Mohasseb ◽  
Ramy Mohamed Mohamed El-Bahnasy
Keyword(s):  
Systematic Review ◽  
Femoral Head ◽  
Femoral Neck ◽  
High Energy ◽  
Femoral Neck Fractures ◽  
Final Outcome ◽  
Cannulated Screws ◽  
Fixed Angle ◽  
Femur Fractures ◽  
Femoral Head Osteonecrosis

Abstract Background Femoral neck fractures in adults younger than age 50 years are uncommon and often the result of high energy trauma. They account for only 2-3% of all femoral neck fractures. Femoral neck fractures are associated with aging and osteoporosis and can occur after relatively trivial trauma in elderly patients. femoral neck fractures are associated with higher incidences of femoral head osteonecrosis and nonunion. Fixation options include cannulated screws, non parallel cannulated screws, medial augmentation plate, and fixed angle femoral neck fixation implants. A systematic review of literature done to evaluate which technique is better. Methods After literature search thirteen articles were found and were reviewed to evaluate final outcome of fixation of neck femur fractures by cannulated screws, non parallel cannulated screws, medial augmentation plate, and fixed angle femoral neck fixation implants. Results After evaluation of all studies the incidence of nonunion, osteonecrosis of femoral head, implant failure & revesion surgery is lower in comparing Targon plate with multiple cannulated screws while we need further studies for application of non parallel screws and medial plate. Conclusion Targon plate recorded low incidence of complications in the final outcome in comparison with multiple cannulated screw while we need further studies for application of Non parallel screws and medial plate.

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