How long noncoding RNAs enforce their will on mitochondrial activity: regulation of mitochondrial respiration, reactive oxygen species production, apoptosis, and metabolic reprogramming in cancer

2017 ◽  
Vol 64 (1) ◽  
pp. 163-172 ◽  
Author(s):  
Boel De Paepe ◽  
Steve Lefever ◽  
Pieter Mestdagh
Keyword(s):  
Reactive Oxygen Species ◽  
Mitochondrial Respiration ◽  
Reactive Oxygen Species Production ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Metabolic Reprogramming ◽  
Mitochondrial Activity ◽  
Activity Regulation ◽  
Oxygen Species ◽  
Species Production

scholarly journals Regulation of mitochondria function by natriuretic peptides

2019 ◽  
Vol 317 (5) ◽  
pp. F1164-F1168
Author(s):  
Mark Domondon ◽  
Anna B. Nikiforova ◽  
Kristine Y. DeLeon-Pennell ◽  
Daria V. Ilatovskaya
Keyword(s):  
Blood Pressure ◽  
Reactive Oxygen Species ◽  
Natriuretic Peptides ◽  
Mitochondrial Respiration ◽  
Reactive Oxygen Species Production ◽  
Current Knowledge ◽  
Fluid Retention ◽  
Oxygen Species ◽  
Species Production ◽  
The Relationship

Natriuretic peptides (NPs) are well known to promote renal Na+ excretion, counteracting the effects of the renin-angiotensin-aldosterone system. Thus, NPs serve as a key component in the maintenance of blood pressure, influencing fluid retention capabilities via osmoregulation. Recently, NPs have been shown to affect lipolysis and enhance lipid oxidation and mitochondrial respiration. Here, we provide an overview of current knowledge about the relationship between NPs and mitochondria-mediated processes such as reactive oxygen species production, Ca2+ signaling, and apoptosis. Establishing a clear physiological and mechanistic connection between NPs and mitochondria in the cardiovascular system will open new avenues of research aimed at understanding and potentially using it as a therapeutic target from a completely new angle.

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